Chapter 32 Antihistamines

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A nursing professor has just completed her lecture regarding hypersensitivity (allergic) responses, focused on Type I reactions. Which of the following statements made by her students will show that the students understood the material? Choose all that apply.

"It occurs within minutes of exposure to the antigen." "It is an immunoglobulin E (IgE)-induced response." "Anaphylaxis is a type I response."

he pharmacology instructor is discussing the adverse effects of diphenhydramine. What are they?

Adverse effects of first-generation antihistamines include urinary retention or frequency, sedation, dry mouth, blurred vision, and gastrointestinal distress.

Your client has a history of post-transfusion reactions. Her medical provider has ordered medication to prevent this. Which of the following medications would you anticipate being ordered for this client?

Benadryl: Diphenhydramine

The health care provider has ordered promethazine (Phenergan) for a client who is having a severe allergic reaction. The nurse is aware that this medication is also used to treat what condition?

Nausea and vomiting

What type of antihistamine is typically preferred for older adults?

Second-generation

The substances released from mast cells are responsible for what physiological response? Select all that apply.

inflammation bronchoconstriction

Second-generation H1 antagonists cause less CNS depression because they are selective for peripheral H1 receptors and because of which other property?

they do not cross the blood brain barrer Fexofenodine


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