Chemokines and Cytokines (Mayank)

Important characteristics of Chemokines and Receptors.

- Specificity - Pathogenically important - RAPID

What are constitutive Chemokines responsible for?

Basal Trafficking/Homing

There is a 2 step process going from Vessel to Interstitium and then Interstitium to Airway Epithelium in pathogenesis of Asthma. What chemokines are involved in Interstitium to Airway Epithelium pathway?

CCL2 CCL5 CCL11

There is a 2 step process going from Vessel to Interstitium and then Interstitium to Airway Epithelium in pathogenesis of Asthma. What chemokines are involved in Vessel to Interstitium pathway?

CCL3 CCL7 CCL22

What Chemokine Receptor is involved with AIDS?

CCR5 and CXCR4

Marked expression of what cytokine is seen in Breast Carcinoma patients?

CXCR4- (CXCL12) b. CCL27/CCR10 c. CCL19 & CCL21/CCR7 4,10,7 CXCR. 12, 27, 19/21 CSCL april 10, 2007. december 27,1921

CCR9 TECK: What organ does this chemokine direct lymphocte honing to?

Gut

Which cytokine induces neutrophil infiltration to cause Bronchopneumonia?

IL-8

What are Chemokines involved with Multiple Sclerosis?

IP-10 (CXCL10) CXCL9 CCL5

What are the targets for MS?

IP-10 antisense CXCR3 Abs

What are Inducible Chemokines responsible for?

Inflammatory

CCR10 MEC: What organ does this chemokine direct lymphocte honing to?

Lungs

Where does Breast Carcinomas tend to metastasize to most of the times?

Lungs Liver Bones

CCR10 CTACK: What organ does this chemokine direct lymphocte honing to?

Skin

CCR4 TARC: What organ does this chemokine direct lymphocte honing to?

Skin

CCR7 SLC ELC: What organ does this chemokine direct lymphocte honing to?

Specialized Lymphoid Tissue

What inhibits CXCR2 and CCR5 and prevents HIV entry into T Helper Cells?

TAK-779