Chemokines and Cytokines (Mayank)
Important characteristics of Chemokines and Receptors.
- Specificity - Pathogenically important - RAPID
What are constitutive Chemokines responsible for?
Basal Trafficking/Homing
There is a 2 step process going from Vessel to Interstitium and then Interstitium to Airway Epithelium in pathogenesis of Asthma. What chemokines are involved in Interstitium to Airway Epithelium pathway?
CCL2 CCL5 CCL11
There is a 2 step process going from Vessel to Interstitium and then Interstitium to Airway Epithelium in pathogenesis of Asthma. What chemokines are involved in Vessel to Interstitium pathway?
CCL3 CCL7 CCL22
What Chemokine Receptor is involved with AIDS?
CCR5 and CXCR4
Marked expression of what cytokine is seen in Breast Carcinoma patients?
CXCR4- (CXCL12) b. CCL27/CCR10 c. CCL19 & CCL21/CCR7 4,10,7 CXCR. 12, 27, 19/21 CSCL april 10, 2007. december 27,1921
CCR9 TECK: What organ does this chemokine direct lymphocte honing to?
Gut
Which cytokine induces neutrophil infiltration to cause Bronchopneumonia?
IL-8
What are Chemokines involved with Multiple Sclerosis?
IP-10 (CXCL10) CXCL9 CCL5
What are the targets for MS?
IP-10 antisense CXCR3 Abs
What are Inducible Chemokines responsible for?
Inflammatory
CCR10 MEC: What organ does this chemokine direct lymphocte honing to?
Lungs
Where does Breast Carcinomas tend to metastasize to most of the times?
Lungs Liver Bones
CCR10 CTACK: What organ does this chemokine direct lymphocte honing to?
Skin
CCR4 TARC: What organ does this chemokine direct lymphocte honing to?
Skin
CCR7 SLC ELC: What organ does this chemokine direct lymphocte honing to?
Specialized Lymphoid Tissue
What inhibits CXCR2 and CCR5 and prevents HIV entry into T Helper Cells?
TAK-779