Dextrose 50%

Pediatric Dosage

1: Administer 0.5- 1 Gm/kg Of A Dextrose 10% Solution; Recommended To Give Slowly Over A 20 Minute Period 2: Dilute D50 To A 1:4 Solution. (250 Bag NS, Draw Out 50 mL Fluid And Add Full Amp Of D50 = Dextrose 10% In NS = 10 Grams/100mL = 1 Gram/ 10mL)

Adverse Reactions

1: Cerebral Edema In Children When Given IV Undiluted 2: Worsening Elevated ICP Or Cerebral Edema From Trauma Or CVA 3: Extravasation Leads To Severe Tissue Necrosis (Make Sure IV Is Good) 4: Sclerosing Effect On Peripheral Veins

Special Notes

1: Determine Blood Glucose Level Before Administration Of Dextrose 2: Should Not Be Administered Through Small Vein

Contraindications

1: Known Thiamine Deficiency (Relative, If Suspected Give Thiamine First) 2: Delirium Tremens; Use With Caution In Patients With Acute Alcoholism, May Be Ineffective Without Thiamine

Incompatabilities/ Drug Interactions

1: Sodium Bicarbonate 2: Diazepam (Valium) Will Precipitate If Given Concurrently Without Flushing

Class

Carbohydrate Hyperglycemic

Name

Dextrose 50% D50

Adult Dosage

Hypoglycemia: 12.5-25 Gm IV (Half To Whole Amp) Repeat In 10 Minutes If Blood Glucose Not Increased (1 Amp = 25Gm/ 50mL)

Routes Of Administration

IV Bolus (Rapid)

Indications For Field Use

Known Hypoglycemia

Mechanism Of Action

Pharmacological: Aerobic Metabolic Substrate (ATP Production) Clinical Effects: Reverses CNS Effects Of Hypoglycemia By Rapidly Increasing Serum Glucose Levels Provides Short-Term Osmotic Diuresis

Onset Of Action, Peak Effects, Duration Of Action

Seconds, Variable, Variable