Drug class: Tetracyclines

Why is protein synthesis important in antibiotics?

Because antibiotics stop protein synthesis so cells can't divide

Do not administer tetracycline within 2 hours of taking ____ or ____. The antacid present in these formulations inhibits the absorption of the tetracyclines

Didanosine or pediatric powder for oral solution

Therapeutic outcome for tetracyclines

Elimination of bacterial infection

what happens when tetracyclines are administered during the ages of tooth development?

From the last half of pregnancy through 8 years of age, tetracyclines may cause enamel hypoplasia and permanent staining of teeth

Administer all tetracycline products 1 hour or 2 hours after ingesting bc of decreased absorption:

Iron calcium containing foods calcium aluminum magnesium preparations

Warfarin and tetracyclines

May enhance the anticoagulant effects of warfarin. Observe for petechia, ecchymoses, nosebleeds, bleeding gums, dark tarry stools, and bright red or coffee groune emesis

Common adverse effects of tetracyclines

Nausea, vomiting, abdominal cramps, diarrhea, photosensitivity

Premedication assessment of tetracyclines

Obtain baseline assessments of presenting symptoms Record temperature, pulse, respirations, BP, and hydration status Assess for and record any gastric symptoms present before beginning therapy Assess for any allergies Obtain baseline lab studies ordered and review results

How are tetracyclines available

PO

What are tetracyclines particularly effective against

Skin (acne), rickettsial, and mycoplasmic infections

Class of antibiotics that are effective against gram negative and gram positive bacteria. They act by inhibiting protein synthesis by bacterial cells

Tetracyclines

What are tetracyclines used for?

They are used in patients allergic to the penicillins for the treatment of certain venereal diseases, UTIs, upper respiratory tract infections, pneumonia, and meningitis

Are tetracyclines secreted in breast milk?

Yes