Drug class: Tetracyclines
Why is protein synthesis important in antibiotics?
Because antibiotics stop protein synthesis so cells can't divide
Do not administer tetracycline within 2 hours of taking ____ or ____. The antacid present in these formulations inhibits the absorption of the tetracyclines
Didanosine or pediatric powder for oral solution
Therapeutic outcome for tetracyclines
Elimination of bacterial infection
what happens when tetracyclines are administered during the ages of tooth development?
From the last half of pregnancy through 8 years of age, tetracyclines may cause enamel hypoplasia and permanent staining of teeth
Administer all tetracycline products 1 hour or 2 hours after ingesting bc of decreased absorption:
Iron calcium containing foods calcium aluminum magnesium preparations
Warfarin and tetracyclines
May enhance the anticoagulant effects of warfarin. Observe for petechia, ecchymoses, nosebleeds, bleeding gums, dark tarry stools, and bright red or coffee groune emesis
Common adverse effects of tetracyclines
Nausea, vomiting, abdominal cramps, diarrhea, photosensitivity
Premedication assessment of tetracyclines
Obtain baseline assessments of presenting symptoms Record temperature, pulse, respirations, BP, and hydration status Assess for and record any gastric symptoms present before beginning therapy Assess for any allergies Obtain baseline lab studies ordered and review results
How are tetracyclines available
PO
What are tetracyclines particularly effective against
Skin (acne), rickettsial, and mycoplasmic infections
Class of antibiotics that are effective against gram negative and gram positive bacteria. They act by inhibiting protein synthesis by bacterial cells
Tetracyclines
What are tetracyclines used for?
They are used in patients allergic to the penicillins for the treatment of certain venereal diseases, UTIs, upper respiratory tract infections, pneumonia, and meningitis
Are tetracyclines secreted in breast milk?
Yes