ЁЯОГЁЯОГЁЯЦдЁЯТЪMHC 11ЁЯТЪЁЯЦдЁЯОГЁЯОГ
Antigen recognition
Inactive T cell binding to a specific MHC- antigen complex
Antigen recognition
Inactive T cells have receptors that recognize either class I or class II MHC proteins when they are bound to specific antigens
Class II MHC proteins
antigen-presenting cells (APCS) Examples: monocyte-macrophages dendritic cells
Antigen presentation with class II ╨Ь╨Э╨б 2.Phagocytic APCS engulf the extracellular pathogens.
1. Lysosomal action produces antigenic fragments.
Classes of MHC proteins 1. Class I MHC proteins Present in membranes of all nucleated cells Triggered by viral or bacterial infection of a body cell
2. Class II MHC proteins Present only in membranes of ЁЯРаantigen-presenting cells (APCS)ЁЯРа Ex:monocyte-macrophages,dendritic cells Appear only when the cell is processing antigens
Antigen presentation with class II ╨Ь╨Э╨б 1. Phagocytic APCS engulf ЁЯРаthe extracellular pathogens.
2. Lysosomal action produces ЁЯРаantigenic fragments.
Antigen presentation with class II ╨Ь╨Э╨б 1.Phagocytic APCS engulf the extracellular pathogens. 2. Lysosomal action produces antigenic fragments.
3. The endoplasmic reticulum produces class II MHC proteins.
Antigen presentation with class II ╨Ь╨Э╨б 3. The endoplasmic reticulum produces ЁЯРаclass II MHC proteins.
4. Antigenic fragments are bound ЁЯРаto class II MHC proteins.
Antigen presentation with class II ╨Ь╨Э╨б 4. Antigenic fragments are bound to class II MHC proteins.
5. Antigenic fragments are displayed by class I MHC proteins on the plasma membrane.
Antigen presentation with class II ╨Ь╨Э╨б 4. Antigenic fragments are bound ЁЯРа to class II MHC proteins.
Antigen presentation with class II ╨Ь╨Э╨б 5. Antigenic fragments are displayed by ЁЯРаclass I MHC proteinЁЯЪйplasma membrane.
Antigen recognition Inactive T cell binding to a specific MHC- antigen complex Inactive T cells have receptors that recognize either class I or class II MHC proteins when they are bound to specific antigens
Antigen recognition T cell will bind only to a complex containing the antigen that T cell is programmed to detect
Class II MHC proteins
Present only in membranes of antigen-presenting cells (APCS)
Antigen recognition
T cell will bind only to a complex containing the antigen that T cell is programmed to detect
Inactive T cell Infected body cell (including APCS)
ЁЯТЪT cell receptor ЁЯТЪAntigen ЁЯТЪMHC protein Antigen recognition- protein