Sweat

What is the pathology in cystic fibrosis that we detect in the sweat chloride test?

-abnormal reabsorption of chloride back into the skin after a person sweats.

What is the most common genetic defect seen in the Caucasian population? what is its incidence rate?

-cystic fibrosis -1 in 200 are carriers -1 in 40,000 affected

What is the sweat chloride test used for?

-diagnose Cystic Fibrosis

Interpret the results of the sweat chloride test

-increased levels of chloride in sweat indicates CF - >60meq then CF - 40-60 meq then grey zone, rerun

What is the pylocarpine iontophoresis principle?

1) pylocarpine (drug) given to induce sweat glands 2) electrode - drives pylocarpine to area and gives electrical current to induce sweating 3)filter paper: weighed pre and post. used to collect sweat 4) CL- measured off paper to determine

What is the #1 killer of CF patients?

Burkholderia Sepacia

In the 1980's the gene for cystic fibrosis was discovered, what chromosome is it located on?

chromosome 7

what is the purpose of sweat?

regulate body temperature

What is a test we do on sweat?

sweat chloride test