Toxicity - Which vitamin and level of toxicity is the symptom associated with?

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gout

niacin

diabetic hyperglycemia, glycosuria, ketosis, insulin required

niacin (acute chronic)

duodenal ulcers

niacin (acute chronic)

gout-induced arthritis

niacin (acute chronic)

hyperglycemia

niacin (acute chronic)

↑ serum uric acid

niacin (acute chronic)

GI disturbances like heartburn, nausea, vomiting

niacin (acute)

pruritus skin flush

niacin (acute)

↑ intracranial blood flow

niacin (acute)

headaches

niacin (acute), also pyridoxal phosphate

Hepatotoxicity

niacin (chronic)

cardiac arrhythmia and atrial fibrillation

niacin (chronic)

jaundice and cholestasis

niacin (chronic)

parenchyma necrosis

niacin (chronic) prevents fat from leaving liver --> fatty liver

differentiate between Niacin, Pyridoxine, and folate toxicity symptoms..

Niacin: Pruritus (skin flush), Gout, Hyperglycemia, Hepatotoxicity Pyridoxine: Sensory Neuropathy (Tingling) Folate: Seizure, Spasms, Uncontrolled Moves (Parkinson vibes) PRUNES GIVE HEAVY HEMORRHOIDS SOFT NECTARINES TOUCH STALE STRAWBERRIES UNNERVE ME

Nephrotoxicity

folate

depression

folate

diuresis

folate

irritability

folate

malaise

folate

neurotoxicity

folate

renal hypertrophy

folate

spasms

folate

tubular dilation

folate

↑ aggressivenes

folate

↑ blood in urea

folate

↑ creatinine

folate

why does folate cause ↑ in moodiness?

folate must get polyglutamated and interferes with glutamate decarboxylase (which is involved with GABA creation). Recall: GABA is an anti-excitatory or inhibitory neurotransmitter

Nerve function deficit

pyridoxal phosphate

fatigue

pyridoxal phosphate

feet numbness

pyridoxal phosphate

hands clumsy

pyridoxal phosphate

unsteady walk

pyridoxal phosphate


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