Toxicity - Which vitamin and level of toxicity is the symptom associated with?
gout
niacin
diabetic hyperglycemia, glycosuria, ketosis, insulin required
niacin (acute chronic)
duodenal ulcers
niacin (acute chronic)
gout-induced arthritis
niacin (acute chronic)
hyperglycemia
niacin (acute chronic)
↑ serum uric acid
niacin (acute chronic)
GI disturbances like heartburn, nausea, vomiting
niacin (acute)
pruritus skin flush
niacin (acute)
↑ intracranial blood flow
niacin (acute)
headaches
niacin (acute), also pyridoxal phosphate
Hepatotoxicity
niacin (chronic)
cardiac arrhythmia and atrial fibrillation
niacin (chronic)
jaundice and cholestasis
niacin (chronic)
parenchyma necrosis
niacin (chronic) prevents fat from leaving liver --> fatty liver
differentiate between Niacin, Pyridoxine, and folate toxicity symptoms..
Niacin: Pruritus (skin flush), Gout, Hyperglycemia, Hepatotoxicity Pyridoxine: Sensory Neuropathy (Tingling) Folate: Seizure, Spasms, Uncontrolled Moves (Parkinson vibes) PRUNES GIVE HEAVY HEMORRHOIDS SOFT NECTARINES TOUCH STALE STRAWBERRIES UNNERVE ME
Nephrotoxicity
folate
depression
folate
diuresis
folate
irritability
folate
malaise
folate
neurotoxicity
folate
renal hypertrophy
folate
spasms
folate
tubular dilation
folate
↑ aggressivenes
folate
↑ blood in urea
folate
↑ creatinine
folate
why does folate cause ↑ in moodiness?
folate must get polyglutamated and interferes with glutamate decarboxylase (which is involved with GABA creation). Recall: GABA is an anti-excitatory or inhibitory neurotransmitter
Nerve function deficit
pyridoxal phosphate
fatigue
pyridoxal phosphate
feet numbness
pyridoxal phosphate
hands clumsy
pyridoxal phosphate
unsteady walk
pyridoxal phosphate