VIROLOGY

A. Giant multinucleated cells

Characteristic cytopathic effect associated with respiratory syncytial virus is A. Giant multinucleated cells B. Basophilic intranuclear inclusions C. Eosinophilic cytoplasmic inclusions D. Shrunken cells with multilobed nuclei

B. HBV

Characteristics of this DNA hepatitis virus include infections spread by contaminated body fluids, 50- to 180-day incubation period, and chronic infections. A. HAV B. HBV C. HCV D. HEV

B. Measles

The appearance of Koplik spots in the oral mucosa of patients is characteristic of infection with what viral agent? A. Hepatitis B. Measles C. Rabies D. Smallpox

D. Herpes simplex virus

A 25-year-old patient presented with multiple vesicles around the mouth. Material from the lesions was obtained by needle aspiration and inoculated to MRC-5 cells. After 1 day, the cytopathic effect included foci of "ballooned" and lysed cells. These observations suggest infection with A. Adenovirus B. Cytomegalovirus C. Epstein-Barr virus D. Herpes simplex virus

A. -80°C

A clinical specimen is received in viral transport medium for viral isolation. The specimen cannot be processed for 72 hours. At what temperature should it be stored? A. -80°C B. -20°C C. 4°C D. 22°C

B. Attenuated viruses

The Sabin polio vaccine uses which of the following? A. Formalin-inactivated viruses B. Attenuated viruses C. Recombinant viral antigens D. DNA

D. Thrush

Which of the following diseases is not associated with herpes simplex virus? A. Cold sores B. Encephalitis C. Genital heres D. Thrush

A. Smallpox

Which of the following has been declared eradicated by the World Health Organization? A. Smallpox B. Human T cell lymphotropic virus C. Hepatitis G virus D. Eastern equine encephalitis

A. HAV

Which of the following hepatitis viruses is typically transmitted by the fecal-oral pathway? A. HAV B. HBV C. HCV D. HGV

C. It is known to produce defects in fetuses during the early stages of pregnancy.

Which of the following is associated with the rubella virus? A. It is a DNA virus. B. It is a member of the same taxonomic family as measles virus. C. It is known to produce defects in fetuses during the early stages of pregnancy. D. It is transmitted by an arthropod vector

A. Cold sores

Which of the following is caused by a herpes virus? A. Cold sores B. Hemorrhagic fever C. Polio D. Rabies

D. Can self-replicate in the appropriate host cell

Which of the following is not a general characteristic of a virus? A. Obligate intracellular parasite B. Does not produce ATP C. Genome is surrounded by a protein coat D. Can self-replicate in the appropriate host cell

B. Mitosis

Which of the following is not a step involved in virus replication? A. Attachment B. Mitosis C. Penetration D. Release

C. Malaria

Which of the following opportunistic diseases is not closely associated with acquired immune deficiency syndrome? A. Cryptococcosis B. Cryptosporidiosis C. Malaria D. Mycobacteriosis

A. Adenovirus

Which of the following viruses is predominantly associated with respiratory disease and epidemics of keratoconjunctivitis? A. Adenovirus B. Molluscum contagiosum virus C. Norwalk virus D. Rotavirus

C. Varicella

The viral disease shingles, which causes extreme tenderness along the dorsal nerve roots and a vesicular eruption, has the same etiologic agent as A. Rubeola B. Vaccinia C. Varicella D. Variola

D. Papillomavirus

The virus associated with warts is A. Flavivirus B. Morbillivirus C. Mumps virus D. Papillomavirus

B. DNA virus utilizing reverse transcriptase

The virus that causes hepatitis B is characterized as a A. Defective DNA virus requiring delta virus to complete its replication cycle B. DNA virus utilizing reverse transcriptase C. Nonenveloped DNA virus D. Single-stranded RNA virus

A. Acute nonspecific febrile syndrome

Enteroviruses are most often associated with A. Acute nonspecific febrile syndrome B. Bronchitis and pneumonia C. Lower respiratory tract infections D. Upper respiratory tract infections

C. Are most often acquired by contact with blood

Hepatitis C virus infections A. Are commonly diagnosed during the acute stage B. Are uncommon in the U.S. C. Are most often acquired by contact with blood D. Seldom results in chronic infection

B. Antigenic shift

Influenza A virus undergoes recombination events that produce new strains; this is referred to as A. Antigenic drift B. Antigenic shift C. Reactivation D. Viral latency

D. Smallpox

Although there have been no natural cases of this serious disease in about 30 years, which of the following is considered a potential bioterrorism disease A. Dengue B. Ebola hemorrhagic fever C. Shingles D. Smallpox

B. Epstein-Barr virus

An 18-year-old male presents to his family physician complaining of sore throat and fatigue. The patient is found to have a fever and swollen cervical lymph nodes. A complete blood count and differential reveal lymphocytosis and many reactive (atypical) lymphocytes. The physician should suspect an infection caused by A. Adenoviruses B. Epstein-Barr virus C. Parainfluenza virus D. Varicella-zoster virus

D. Varicella-zoster

An example of a virus associated with latent infections is A. Influenza B. Rotavirus C. Rubella D. Varicella-zoster

D. Are transmitted by arthropods

Arboviruses A. Only infect humans B. Often cause hepatitis C. Typically infect lymphocytes D. Are transmitted by arthropods

C. Myocarditis

Coxsackie viruses are associated with A. Gastrointestinal disease B. Hepatitis C. Myocarditis D. The common cold

C. Roseola

Human herpesviruses 6 and 7 are associated with a childhood disease called A. Chickenpox B. Measles C. Roseola D. Zoster

B. Parotid glands

Mumps is characterized by an infection of the A. Central nervous system B. Parotid glands C. Pancreas D. Thymus

A. Hepatitis A

Jaundice is a common clinical symptom of which of the following viral diseases? A. Hepatitis A B. Infectious mononucleosis C. Rabies D. Varicella

D. Human herpes virus 8

Kaposi sarcoma is associated with infection by A. Adenovirus B. Cytomegalovirus C. Hepatitis E virus D. Human herpes virus 8

D. Pox viruses

Molluscum contagiosum virus is a member of the A. Adenoviruses B. Herpes viruses C. Papovaviruses D. Pox viruses

D. Rabies virus

Negri bodies may be found in brain tissue of humans or animals infected with A. Adenovirus B. Filovirus C. Measles virus D. Rabies virus

C. Rubella

The togavirus known to produce fetal defects is: A. Influenza B. Rotavirus C. Rubella D. Varicella

C. Picornaviridae

Poliovirus is a member of the family A. Flaviviridae B. Paramyxoviridae C. Picornaviridae D. Reoviridae

C. Reverse transcriptase

RNA-dependent DNA polymerase is also called A. Gyrase B. Neuraminidase C. Reverse transcriptase D. Transaminase

A. Central nervous system

Rhabdovirus is most noted for causing infections of the A. Central nervous system B. Gastrointestinal tract C. Lower respiratory tract D. Upper respiratory tract

B. Cytomegalovirus

The tubular cells of the human kidney shed which of the following viruses for prolonged periods? A. Adenovirus B. Cytomegalovirus C. Epstein-Barr virus D. Rubella virus

B. Acute nonbacterial gastroenteritis in infants and young children

Rotavirus is the most common etiologic agent of A. Acute nonbacterial encephalitis in children B. Acute nonbacterial gastroenteritis in infants and young children C. Chronic nonbacterial pharyngitis in children and young adults D. Chronic nonbacterial retinitis in children

A. During hepatitis B virus infection when anti-HBc IgM is the only serologic marker

The "core window" refers to the time A. During hepatitis B virus infection when anti-HBc IgM is the only serologic marker B. During hepatitis B virus infection when HBc is the only serologic marker C. During hepatitis A virus infection when HAc is the only serologic marker D. During hepatitis C virus infection when the virus is latent 25. Human herpesviruses 6 and 7

C. Human fibroblast cells

The type of cell culture that best supports the growth of cytomegalovirus is A. HeLa cells B. HEp-2 cells C. Human fibroblast cells D. Primary monkey kidney (PMK) cells

B. Hepatitis C virus

The use of cell cultures has enabled virologists to isolate and identify many clinically important viruses. However, because some viruses cannot be grown in cell cultures, these agents are best diagnosed by serologic testing. Such an agent is A. Cytomegalovirus B. Hepatitis C virus C. Herpes simplex virus 2 D. Respiratory syncytial virus

A. CD 4

The molecular receptor of the virus causing acquired immune deficiency syndrome is A. CD 4 B. CDS C. Fc receptor D. Complement receptor

D. Papillomavirus

The most common cause of cervical cancer is A. Cytomegalovirus B. Enterovirus C. Molluscum contagiosum D. Papillomavirus

C. Enterovirus

The poliovirus, an RNA virus, is a(n) A. Adenovirus B. Coxsackie virus C. Enterovirus D. Rhinovirus

C. Retroviridae

The retrovirus responsible for causing acquired immune deficiency syndrome is a member of the family A. Orthomyxoviridae B. Paramyxoviridae C. Retroviridae D. Flaviviridae