Drugs and Behavior Chapter 6: Hallucinogens

How potent is LAA compared to LSD?

1/30

If a typical aspirin pill is 325,000 mcg, then that would roughly equate to what typical street dose of LSD?

50 mcg

What do hallucinogens do to serotonin?

Agonist: mimics the effects.

Which is an anticholinergic hallucinogenic drug that has been linked to poisoning events throughout history?

Atropine

Dr. Henslee only has one hour between her classes, so if she wants to get a LSD-like high, but with a short duration, which hallucinogen should she use?

DMT.

Atropine is to belladonna as Hyoscyamine is to...

Datura

MDMA effects what two main NTs?

Dopamine and serotonin.

Channing is trying to talk his friend Vin out of using LSD. He tells Vin, "You'll get addicted. It can give you flashbacks for years afterwards, too. It can also make you psychotic or you could get chromosome damage!" Which of the issues Channing presented is a possible consequence of LSD use?

Flashbacks.

What do PCP and Ketamine effect?

Glutamate NMDA agonist, increases dopamine release.

Renan is in the Amazon observing a shaman ritual using ayahuasca. What hallucinogen is in the drink, and what neurotransmitter does it resemble?

Harmine; it resembles serotonin.

What is chemically similar to serotonin, norepinephrine, or acetylcholine?

Henbane, Datura, Mandrake.

What is preventing the study of MDMA for therapeutic applications such as treatment for PTSD?

It is a Schedule I controlled substance.

Which of the following is true about the history of LSD?

It mostly works by affecting 5HT.

Anderson has just been diagnosed with hallucinogen persisting perception disorder. Which drug most likely caused this condition?

LSD

If you develop tolerance to psilocybin, you will very likely have cross-tolerance for what other hallucinogen?

LSD

Nate swallows a tasteless, nearly odorless powder and in about an hour starts to see images with his eyes closed, experience synesthesia, multilevel reality, and exaggerated experiences. He most likely ingested

LSD

Tanner is taking a drug that came on a small square of paper with an image of Mickey Mouse on it. What drug is Tanner using?

LSD

Which hallucinogen is capable of producing amphetamine-like stimulant effects?

MDMA

All of the following are hallucinogens related to norepinephrine...

MDMA, STP, and Mescaline.

What are myths surrounding LSD?

More creativity, having flashbacks, perception disorders, increasing criminal/violent behavior, damaging chromosomes, and produce panic attacks.

What is scopolamine?

Nightshade, Mandrake Root.

Avante is high on a hallucinogen that blocks a subtype of glutamate receptor in the brain. He is displaying aggressive behavior, agitation, disorientation, and a lack of pain response (analgesia). What drug is he using?

PCP

Based upon animal studies of self-administration, it appears that one could develop dependence on

PCP

Which is a correct pairing of hallucinogen and the neurotransmitter it affects?

PCP - glutamate Atropa belladona - ACh psilocybin - serotonin Amanita Muscaria - GABA/Glutamate

Which drug does have 5HT as its major mechanism of action?

Psilocybin, LSD, Ketamine.

Which drug does not have 5HT as its major mechanism of action?

Salvia divinorum

Which of these is not chemically similar to serotonin, norepinephrine, or acetylcholine?

Salvia divinorum

Hallucinations experienced by people with Schizophrenia differ from those experienced by people who took LSD in all of the following ways except

Schizophrenics are susceptible to suggestion when hallucinating.

LSD, harmine, and DMT all derive their properties from a resemblance to which neurotransmitter?

Serotonin

Gegard is using LSD and is experiencing synesthesia while watching a trumpet player perform. He tells his companion that he sees something coming out of the trumpet players horn when he plays. What does he most likely see?

Sound Waves

What is true about hallucinogens?

They have been used in religious rituals. They are generally non-addictive. Their actions depend on the setting. They are the oldest of all drugs.

Annette is using LSD and is experiencing a sense of timelessness and that her mind is separate from her body. How much time has passed since she took the LSD?

Three to five hours

Where is bufotenine found?

Toads

If the original medical purpose of Lysergic Acid was used today, who would benefit?

a woman giving childbirth

What does Amanita Muscaria do to GABA?

agonist: mimics the effects. Agonist at NDMA glutamate receptors.

ACh is associated with...

delirants like scopolamine, hyoscyamine, and atropine.

Consequences of heavy and prolonged Ecstasy use include all of the following except

depression.

During her psychedelic trip, a fly in the window looks like big, black fighter jet in the sky to Kate. Kate is experiencing

exaggerated configurations of objects.

Double-blind studies indicate that subjects cannot tell the difference between LSD and

mescaline.

What are some plant-based hallucinogens?

peyote, atropa belladonna, ibogaine.

Which is not technically a plant-based hallucinogen?

psilocybin

The experiences one has on LSD tend to be _________ compared to the _________ hallucinations of a person with Schizophrenia.

visual; auditory