exam 4: human growth hormone (HGH)

what happens to the body with chronic use of HGH?

- increased mobilization of FFA from adipose - inhibiton of glucose uptake at muslce

DHEA was found not to be associated with

- memory loss - immune function - improvements in body comp - improvements with cardiovascular disease

DHEA was found to be associated with

- slight changes in lipoprotein levels - precursors for development of breast cancer - formation of acne

how much more HGH do individuals use then they are supposed to?

10-20x's reccomended therapeutic dosage

when did HGH gain its popularity and why?

1980s due to dislike towards anabolic steroids

action of HGH is done in ____ stages

2

DHEA peaks at age

30 and decreases thereafter

the effects of HGH wear off after

4 hours

it was found that HGH increase ____ and not _____

LBM (organs), and not muscle mass/athletic performance

DHEA is produced by the

adrenal glands

how is DHEA administered?

oral (injection unusual)

prior to 1985, HGH was obtained from where

pituitary of cadavers

what is the synthesis of androgens/estrogen?

progesterone--->hydroprogesterone---->adrostenedione----> testosterone--->estradiol

DHEA was also believed to increase what other hormones?

testosterone and androstenedione

does every organ depend on HGH?

yes

is HGH regulated?

yes, its distribution is tightly regulated for HGH deficient patients

what causes genetically engineered HGH to be made?

contraction of disease causing liver damage in 4 boys

what is DHEA?

dehydroepiandrosterone

DHEA has been found to increase...

estrogen levels after 4 weeks of use

what are the adverse effects of HGH?

increased internal organ growth can cause development of chronic diseases such as acromegaly and giantism

increased LBM was found to be due to

increased size of internal organs and water retention

how is HGH administered?

injection

what is the first stage of HGH?

its first effects are insulin like and involve - increased amino acid uptake into skeletal muscle - increased glucose uptake in skeletal muscle - blocks lipid breakdown at adipose tissue