exam 4: human growth hormone (HGH)
what happens to the body with chronic use of HGH?
- increased mobilization of FFA from adipose - inhibiton of glucose uptake at muslce
DHEA was found not to be associated with
- memory loss - immune function - improvements in body comp - improvements with cardiovascular disease
DHEA was found to be associated with
- slight changes in lipoprotein levels - precursors for development of breast cancer - formation of acne
how much more HGH do individuals use then they are supposed to?
10-20x's reccomended therapeutic dosage
when did HGH gain its popularity and why?
1980s due to dislike towards anabolic steroids
action of HGH is done in ____ stages
2
DHEA peaks at age
30 and decreases thereafter
the effects of HGH wear off after
4 hours
it was found that HGH increase ____ and not _____
LBM (organs), and not muscle mass/athletic performance
DHEA is produced by the
adrenal glands
how is DHEA administered?
oral (injection unusual)
prior to 1985, HGH was obtained from where
pituitary of cadavers
what is the synthesis of androgens/estrogen?
progesterone--->hydroprogesterone---->adrostenedione----> testosterone--->estradiol
DHEA was also believed to increase what other hormones?
testosterone and androstenedione
does every organ depend on HGH?
yes
is HGH regulated?
yes, its distribution is tightly regulated for HGH deficient patients
what causes genetically engineered HGH to be made?
contraction of disease causing liver damage in 4 boys
what is DHEA?
dehydroepiandrosterone
DHEA has been found to increase...
estrogen levels after 4 weeks of use
what are the adverse effects of HGH?
increased internal organ growth can cause development of chronic diseases such as acromegaly and giantism
increased LBM was found to be due to
increased size of internal organs and water retention
how is HGH administered?
injection
what is the first stage of HGH?
its first effects are insulin like and involve - increased amino acid uptake into skeletal muscle - increased glucose uptake in skeletal muscle - blocks lipid breakdown at adipose tissue