Hematology - chp 7 Qs

Macrocytic, normochromic anemia

According to the morphological classification of anemias, megaloblastic anemia is a: a. Macrocytic, hypochromic anemia b. Macrocytic, hyperchromic anemia c. Macrocytic, normochromic anemia d. Normocytic, normochromic anemia

Increased reticulocyte count

Macrocytosis associated with acute blood loss is characterized by: a. Decreased reticulocyte count b. Increased reticulocyte count c. Pancytopenia d. Macro-ovalocytes

Ineffective erythropoiesis and decreased reticulocytes

Megaloblastic anemia is associated with: a. Ineffective erythropoiesis and increased reticulocytes b. Ineffective erythropoiesis and decreased reticulocytes c. Ineffective erythropoiesis and decreased LDH d. Ineffective erythropoiesis and decreased erythropoietin

IF (Intrinsic factor)

The glycoprotein necessary for absorption of vitamin B12 is: a. Albumin b. Transcobalamin II c. Haptoglobin d. IF (Intrinsic factor)

Defective DNA synthesis and abnormal nuclear maturation

The pathophysiology of megaloblastic anemia is: a. Defective RNA synthesis and abnormal cytoplasm maturation b. Defective DNA synthesis and abnormal nuclear maturation c. Defective RNA synthesis and abnormal nuclear maturation d. Defective DNA synthesis and abnormal cytoplasm maturation

Part I abnormal, part II corrected

Which of the following Schilling test results corresponds to a diagnosis of pernicious anemia? a. Part I abnormal, part II not corrected b. Part I abnormal, part II corrected c. Part I and part II abnormal d. Part I normal, part II corrected

Anemia and jaundice

Which of the following are clinical manifestations of both B12 deficiency and folate deficiency? a. Anemia and jaundice b. Thrombocytosis c. Hemoglobinemia d. Hemoglobinuria

Hyposegmented neutrophils

Which of the following are not seen on the peripheral smear of a patient with megaloblastic anemia? a. Macro-ovalocytes b. Hypersegmented neutrophils c. Hyposegmented neutrophils d. Howell-Jolly bodies

Hypercellular with low M:E ratio

Which of the following are the characteristic findings of the bone marrow in a patient with megaloblastic anemia? a. Hypocellular with low M:E ratio b. Hypercellular with high M:E ratio c. Hypocellular with high M:E ratio d. Hypercellular with low M:E ratio

Hypersegmented neutrophils

Which of the following is associated with pernicious anemia and not macrocytic anemia due to liver disease? a. Increased LD b. Increased bilirubin c. Increased MCV d. Hypersegmented neutrophils

Chronic glossitis

Which of the following is not a cause of vitamin B12 deficiency? a. Atrophic gastritis b. Total gastrectomy c. Blind loop syndrome d. Chronic glossitis

Increased serum iron and serum bilirubin

Which of the following laboratory findings coincide with megaloblastic anemia? a. Increased serum iron and serum bilirubin b. Decreased serum iron and serum bilirubin c. Decreased serum muramidase d. Increased haptoglobin