Mood Stabilizers/Anti-Epileptics: Lithium
Ebstein's anomoly is what?
Atrialized RV, malformed tricuspid valve, and ASD
Lithium is a __ stabilizer
Bipolar (mood stabilizer)
Lithium treats for what? MOA?
Bipolar. Related to Phosphoinositol cascade
Acute lithium toxicity?
GI effects
Lithium can cause what endocrine change?
Hypothyroid
What else decrease clearance of lithium?
NSAIDS: block prosta synthesis in kidney and reduce GFR
Lithium has a __ therapeutic index
Narrow: important to monitor for drug levels throughout tx
Another organ affected by Lithium?
Nephrogenic diabetes insipidus: reduce ability of kidney to concentrate urine by antagonizing ADH in collecting tubule --> polyuria (giving exogenous ADH won't treat b/c lithium kills the ADH)
Lithium is excreted how and why? So, what drugs increase lithium levels?
Since it's a cation, it isn't metabolized and so it is filtered at GFR and excreted by kidney, so thiazide diuretics inc lithium levels
Lithium S.E. in fetus?
Teratogen: Ebstein's anomoly
Chronic lithium toxicity?
Tremor, confusion, ataxia
What anti-epileptic can be used to treat bipolar?
Valproate
Signs of lithium induced hypothyroidism?
c/o weight gain, hair loss, constipation, dry skin