Mood Stabilizers/Anti-Epileptics: Lithium

Ebstein's anomoly is what?

Atrialized RV, malformed tricuspid valve, and ASD

Lithium is a __ stabilizer

Bipolar (mood stabilizer)

Lithium treats for what? MOA?

Bipolar. Related to Phosphoinositol cascade

Acute lithium toxicity?

GI effects

Lithium can cause what endocrine change?

Hypothyroid

What else decrease clearance of lithium?

NSAIDS: block prosta synthesis in kidney and reduce GFR

Lithium has a __ therapeutic index

Narrow: important to monitor for drug levels throughout tx

Another organ affected by Lithium?

Nephrogenic diabetes insipidus: reduce ability of kidney to concentrate urine by antagonizing ADH in collecting tubule --> polyuria (giving exogenous ADH won't treat b/c lithium kills the ADH)

Lithium is excreted how and why? So, what drugs increase lithium levels?

Since it's a cation, it isn't metabolized and so it is filtered at GFR and excreted by kidney, so thiazide diuretics inc lithium levels

Lithium S.E. in fetus?

Teratogen: Ebstein's anomoly

Chronic lithium toxicity?

Tremor, confusion, ataxia

What anti-epileptic can be used to treat bipolar?

Valproate

Signs of lithium induced hypothyroidism?

c/o weight gain, hair loss, constipation, dry skin