Morphine and Heroin

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Heroin can last

6-8 hours

Effects of Naloxone wears off

Between 60-90 minutes after administration

Heroin

Considered a prodrug because it is broken down into an active drug

Main Effects of Morphine and Heroin

Activation of the dopamainergic system and opiod system

Naloxone (Narcan)

An opiate antagonist which reverses opiate overdoses

Endorphins

Feel-good chemicals naturally- manufactured in the brain when the body experiences pain or stress

John Hopkins

Found human brain's neurons had specific receptor sites for opiate drugs: opium, heroin, and morphine

An addicted person would always choose this over morphine

Heroin

Naloxone (Narcan) Can reverse

Heroin OxyContin Percocet Vicodin Math done Morphine

Buprenorphine

Heroine addicts are put on this to wean them off of heroin

Opiates outlasts

Naloxone

F.W. Sertuner

Tried to make a non-addictive substitute and made a new drug 10xs stronger (Heroin)

Opiate Overdose

When opiates settle in the part of the brain that regulates breathing

Naltrexone

opioid antagonist

Heroin

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Vietnam War Study

Social Disproval: One factor that inhibits drug use

Morphine

Low oral bioavailability (25%)

Diacetylmorphine

Medical Term for Heroine

Crosses into the brain slower than heroine

Morphine

opiates (narcotics)

Produce their effects as an agonist on the mu receptors in the central nervous system

Heroin Response

Reduces hunger,fatigue,anxiety, and pain

Bumpernorphine

Replaces the heroin without giving a "rush"

Main Concern for Opiate Overdose

Respiratory Depression

Mu1 receptors

Responsible for a large portion of analgesic (pain management) effects

Mu 2 receptors

Responsible for respiratory distress


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