Morphine and Heroin
Heroin can last
6-8 hours
Effects of Naloxone wears off
Between 60-90 minutes after administration
Heroin
Considered a prodrug because it is broken down into an active drug
Main Effects of Morphine and Heroin
Activation of the dopamainergic system and opiod system
Naloxone (Narcan)
An opiate antagonist which reverses opiate overdoses
Endorphins
Feel-good chemicals naturally- manufactured in the brain when the body experiences pain or stress
John Hopkins
Found human brain's neurons had specific receptor sites for opiate drugs: opium, heroin, and morphine
An addicted person would always choose this over morphine
Heroin
Naloxone (Narcan) Can reverse
Heroin OxyContin Percocet Vicodin Math done Morphine
Buprenorphine
Heroine addicts are put on this to wean them off of heroin
Opiates outlasts
Naloxone
F.W. Sertuner
Tried to make a non-addictive substitute and made a new drug 10xs stronger (Heroin)
Opiate Overdose
When opiates settle in the part of the brain that regulates breathing
Naltrexone
opioid antagonist
Heroin
x-apple-ql-id://692E32C7-88F2-4093-8B0F-0A1AA40059A7/x-apple-ql-magic/0FB7E6B2-F4D6-4149-AFAD-D6A9D92F024F.pdf
Vietnam War Study
Social Disproval: One factor that inhibits drug use
Morphine
Low oral bioavailability (25%)
Diacetylmorphine
Medical Term for Heroine
Crosses into the brain slower than heroine
Morphine
opiates (narcotics)
Produce their effects as an agonist on the mu receptors in the central nervous system
Heroin Response
Reduces hunger,fatigue,anxiety, and pain
Bumpernorphine
Replaces the heroin without giving a "rush"
Main Concern for Opiate Overdose
Respiratory Depression
Mu1 receptors
Responsible for a large portion of analgesic (pain management) effects
Mu 2 receptors
Responsible for respiratory distress
