pathoma - vagina

exposure to what drug/chemical has been linked to adenosis in females

diethylstilbestrol (DES)

What is vaginal carcinoma related too?

exposure to high risk HPV (16, 18, 31, 33)

What is desmin?

intermediate filament in muscle cells

What is the epithelial lining of the vagina?

non-keratinizing squamous epithelium

What is myogenin

nuclear transcription factor in immature skeletal muscle fibers

what are the classic cells found in an embryonal rhabdomyosarcoma

rhabddomyoblasts

what is the other name for an embryonal rhabdomyosarcoma

sarcoma botryides

Where does vaginal carcinoma arise from?

squamous epithelium lining the vaginal mucosa

Where does vaginal carcinoma spread to if its in the lower 1/3 of the vagina

to the inguinal lymph nodes

Where does vaginal carcinoma spread to if its in the upper 2/3 of the vagina

to the regional iliac nodes

What is the precursor lesion to vaginal carcinoma?

vaginal intraepithelial neoplasia (VAIN)

What occurs if the upper 2/3 columnar epithelium is not replaced by stratified squamous

adenosis

exposure to DES in utero can lead to what as an adult?

adenosis

how does an embryonal rhabdomyosarcoma present

as bleeding and grape-like mass protruding from the vagina or penis

describe rhabdomyoblasts

cells with *cytoplasmic cross-striations* and positive staining for *desmin* and *myogenin*

adenosis can eventually lead to what in an adult as they age?

clear cell adenocarcinoma

What age is an embryonal rhabdomyosarcoma typically present

kids <5years old

Which part of the vagina develops as stratified squamous... the lower 1/3 or the upper 2/3

lower 1/3

What is an embryonal rhabdomyosarcoma

malignant proliferation of *immature* *skeletal muscle*

What is clear cell adenocarcinoma

malignant proliferation of glands with clear cytoplasm

What part of the vagina develops as columnar epithelium and then is overtaken by stratified squamous during development... the lower 1/3 or the upper 2/3

the upper 2/3