pathoma - vagina
exposure to what drug/chemical has been linked to adenosis in females
diethylstilbestrol (DES)
What is vaginal carcinoma related too?
exposure to high risk HPV (16, 18, 31, 33)
What is desmin?
intermediate filament in muscle cells
What is the epithelial lining of the vagina?
non-keratinizing squamous epithelium
What is myogenin
nuclear transcription factor in immature skeletal muscle fibers
what are the classic cells found in an embryonal rhabdomyosarcoma
rhabddomyoblasts
what is the other name for an embryonal rhabdomyosarcoma
sarcoma botryides
Where does vaginal carcinoma arise from?
squamous epithelium lining the vaginal mucosa
Where does vaginal carcinoma spread to if its in the lower 1/3 of the vagina
to the inguinal lymph nodes
Where does vaginal carcinoma spread to if its in the upper 2/3 of the vagina
to the regional iliac nodes
What is the precursor lesion to vaginal carcinoma?
vaginal intraepithelial neoplasia (VAIN)
What occurs if the upper 2/3 columnar epithelium is not replaced by stratified squamous
adenosis
exposure to DES in utero can lead to what as an adult?
adenosis
how does an embryonal rhabdomyosarcoma present
as bleeding and grape-like mass protruding from the vagina or penis
describe rhabdomyoblasts
cells with *cytoplasmic cross-striations* and positive staining for *desmin* and *myogenin*
adenosis can eventually lead to what in an adult as they age?
clear cell adenocarcinoma
What age is an embryonal rhabdomyosarcoma typically present
kids <5years old
Which part of the vagina develops as stratified squamous... the lower 1/3 or the upper 2/3
lower 1/3
What is an embryonal rhabdomyosarcoma
malignant proliferation of *immature* *skeletal muscle*
What is clear cell adenocarcinoma
malignant proliferation of glands with clear cytoplasm
What part of the vagina develops as columnar epithelium and then is overtaken by stratified squamous during development... the lower 1/3 or the upper 2/3
the upper 2/3
