PDAT 4- EXAM 2 (Coico)

B

A patient with active rheumatoid arthritis feels systemically ill with low-grade fever, malaise, morning stiffness, and fatigue. The protein(s) or cytokine(s) most likely to be responsible for these symptoms are: A. rheumatoid factor B. TNF and IL-1 C. IL-4 and IL-10 D. Complement components 1-9 E. Gamma globulin

D

An individual normally does not make an immune response to a self-protein because: A. Self-proteins cannot be processed into peptides B. Peptides from self-proteins cannot bind to MHC class I molecules C. Peptides from self-proteins cannot bind to MHC class II molecules D. Lymphocytes that express a receptor reactivate to a self-protein are inactivated by deletion, anergy, or receptor editing E. Developing lymphocytes cannot rearrange V genes required to produce a receptor for self-proteins

E

Assuming there were no other compensatory mechanisms to replace IL-8 function, which of the following would be preserved as a functional activity in an IL-8 knockout mouse strain? A. Activation of neutrophils B. Attraction of neutrophils to sites of tissue damage C. Wound healing D. Extravasation of neutrophils E. Reduction of cytokine production by Th1 cells

E

IL-1, IL-6, and TNF-alpha are pro inflammatory cytokines that are known to: A. cause increased vascular permeability B. act in concert with chemokine to promote migration of inflammatory cells to sites of infection C. initiate acute-phase reactions D. have endogenous pyrogen properties E. All of the above

B

Polarization of naive CD4+ T cell differentiation toward the TH2 lineage is associated with which of the following cytokines? A. IL-1 B. IL-4 C. IL-6 D. IL-23 E. IL-25

B

Rheumatoid factor, found in synovial fluid of patients with rheumatoid arthritis, is most frequently found to be: A. IgM reacting with L chains of IgG B. IgM reacting with H-chain determinants of IgG C. IgE reacting with bacterial antigens D. antibody to collagen E. antibody to DNA

A

Superantigens cause a burst of cytokine production by T cells due to their ability to: A. cross-link the Vb segments of T-cell receptors with class II MHC molecules on APCs B. cross-link the Va segments of T-cell receptors with class II MHC molecules on APCs C. cross-link T cell receptors and CD3 D. cross-link multiple cytokine receptors on a large population of T cells E. cross-link CD3

E

When IL-2 is secreted by antigen-specific T cells activated due to presentation of antigen by APCs, what happens to naive antigen-nonspecific T cells in vicinity? A. They proliferate due to their exposure to IL-2 B. They often undergo apoptosis C. They begin to express IL-2 receptors D. They secrete cytokines associated with their Th phenotype E. Nothing happens

B

Which of the following autoimmune diseases has been proven to be due to a single gene defect? A. Systemic lupus erythematosus B. Autoimmune lymphoproliferative syndrome (ALPS) C. Multiple sclerosis D. Rheumatoid arthritis E. Hashimoto's thyroiditis

C

Which of the following cytokines plays a role in terminating inflammatory responses> A. IL-2 B. IL-4 C. TGF-b D. IFN-a E. IL-3