Pharm ATI CANCER & IMMUNOSUPPRESANT Medications
Chloroquine
*Immunosuppressant* Prevents malaria; *causes photophobia*, blurred vision, nausea, and diarrhea; take drug with food, wear sunglasses, and avoid driving while taking this!
Pegfilgrastim
Cancer Bone marrow stimulant Helps body make more WBCs *after* receiving cancer treatment
Decadron
Cancer Cancer Therapy: steroid
Cysplatin
Cancer Cancer therapy: Alkylating agent
Vincristine
Cancer Cancer therapy: plant alkaloid
Tamoxifen
Cancer • *Estrogen receptor blocker* (Karboski had us learn Raloxifene) • *Stops breast cancer growth*, so used in that tx • *CAUSES endometrial cancer, hypercalcemia, N/V, pulmonary embolism*, *hot flashes*, vaginal discharge, menstrual irregularities, bruising • Anti-estrogenic-used in pre+post menopausal women • Cardiovascular ADRs: chest pain, development of thrombus
Anastrozole
Cancer • Aromatase inhibitor • Stops breast cancer growth, *for postmenopausal women*
Fluoruoracil
Cancer • Cancer therapy: antimetabolite (also called 5-FU)
Hydroxyurea
Cancer • Chemotherapy • Can be *used to treat sickle cell anemia*. • Toxicity: low hgb, low platelets, low neutrophils
Trastuzumab
Cancer • Tx for metastatic breast cancer, used with paclitaxel
Filgrastim
Cancer • Used during chemotherapy • *A leukopoietic growth factor - stimulates bone marrow the produce neutrophils* • ADR:* bone pain* bc bone marrow is stimulated o Notify provider and give opioids • Leukocytosis - WBC above normal range since they are low in cancer o *Decrease dose or d/c if WBC count exceeds 10K* • *Splenomegaly* with long term use o *Evaluate reports of upper left quad abdominal pain* • *Monitor CBC every 2 weeks*
Methotrexate
Cancer • Used in chemotherapy, psoriasis, rheumatoid arthritis • *Interrupts cell production, so monitor for bleeds in GI/mucosa/gums. Use soft brushes. Protect skin.* • Pregnancy Cat X (stops cell production) and *is used to dissolve pregnancy*. Moms need to be on strict birth control. • Don't give with folic acid • *Give with leucovorin (prevents side effects)* • *Due to immunosuppression, REPORT FEVER to provider stat* • *Dosed weekly* • *Sores in mouth (stomatitis) indicates toxicity.*
Cyclosporine
Immunosuppressant •* Immunosuppressant drug for organ transplant recipients: TAKEN FOR THE REST OF THEIR LIFE* • Also used for RA and psoriasis • Common ADRs: *HTN, hirsutism, gingival hyperplasia, headache, tremor, burning sensation in eyes (if opthalmic)* • Serious ADRs:* hyperkalemia,* hepatotoxic, opportunistic infection, encephalopathy, nephrotoxicity • *Avoid: infected persons, potassium sparing drugs, grapefruit juice, live vaccines*