Quiz 2 - Cannabinoids
MAGL
monoacylglycerol lipase
THC and CBD
most abundant cannabinoids found in marijuana
THC
phytocannabinoid that binds to both endocannabinoid receptors
CBD
phytocannabinoid that binds to neither endocannabinoid receptors
g-protein coupled
CB1 and CB2 are both _________ receptors.
CNS
CB1 is the most abundant GPCR in the ________.
T
CB2 receptors are found on microglia, astrocytes, and endothelial cells within the CNS (T/F)
F
CBD effects are CB receptor mediated (T/F).
F
New generation synthetic cannabinoids are less selective targets, psychoactive, and more dependent-inducing. (T/F)
CB1 and/or CB2
Pharmacological effects of cannabis explained by activation of _________ receptor.
CB1, retrograde
The __________ receptor acts as a negative feedback modulator of synaptic transmission, by _______________ transmission.
CB2, CNS
_______ receptor is significantly upregulated in activated glial cells and plays an important role in regulating _______ inflammation.
eCB fxns
analgesia, stress modulation, appetite regulation, energy balance and metabolism, memory, immune suppression
marinol, cesamet
approved in 1990s for chemotherapy-induced nausea, vomiting, and wasting syndromes
lipid precursors
endocannabinoids are cleaved by these on demand
2-AG
endogenous ligand for cannabinoid receptors, can bind to both CB1 and CB2
anandamide
endogenous ligand for cannabinoid receptors, shows selectivity for binding at the CB1 receptor
FAAH, MAGL
enzymes invovled in degredation of endogenous ligands for cannabinoid receptors
FAAH
fatty acid amide hydrolase
female marijuana plants
secretes the highest concentration in resin
phytocannabinoids
specific chemical class found in Cannabis sativa (marijuana)
arachidonic acid
the byproduct of endocannabinoid degradation
CB1
the receptor found primarily on the presynaptic membrane of neurons, ubiquitous it is coupled to G proteins, causing inhibition of adenylyl cyclase, influencing numerous transcription factors and potassium channels
CB2
the receptor which is more localized, specifically to immune cells
anandamide, 2-AG
the two endogenous ligands for CB1 and CB2