Quiz 2 - Cannabinoids

MAGL

monoacylglycerol lipase

THC and CBD

most abundant cannabinoids found in marijuana

THC

phytocannabinoid that binds to both endocannabinoid receptors

CBD

phytocannabinoid that binds to neither endocannabinoid receptors

g-protein coupled

CB1 and CB2 are both _________ receptors.

CNS

CB1 is the most abundant GPCR in the ________.

T

CB2 receptors are found on microglia, astrocytes, and endothelial cells within the CNS (T/F)

F

CBD effects are CB receptor mediated (T/F).

F

New generation synthetic cannabinoids are less selective targets, psychoactive, and more dependent-inducing. (T/F)

CB1 and/or CB2

Pharmacological effects of cannabis explained by activation of _________ receptor.

CB1, retrograde

The __________ receptor acts as a negative feedback modulator of synaptic transmission, by _______________ transmission.

CB2, CNS

_______ receptor is significantly upregulated in activated glial cells and plays an important role in regulating _______ inflammation.

eCB fxns

analgesia, stress modulation, appetite regulation, energy balance and metabolism, memory, immune suppression

marinol, cesamet

approved in 1990s for chemotherapy-induced nausea, vomiting, and wasting syndromes

lipid precursors

endocannabinoids are cleaved by these on demand

2-AG

endogenous ligand for cannabinoid receptors, can bind to both CB1 and CB2

anandamide

endogenous ligand for cannabinoid receptors, shows selectivity for binding at the CB1 receptor

FAAH, MAGL

enzymes invovled in degredation of endogenous ligands for cannabinoid receptors

FAAH

fatty acid amide hydrolase

female marijuana plants

secretes the highest concentration in resin

phytocannabinoids

specific chemical class found in Cannabis sativa (marijuana)

arachidonic acid

the byproduct of endocannabinoid degradation

CB1

the receptor found primarily on the presynaptic membrane of neurons, ubiquitous it is coupled to G proteins, causing inhibition of adenylyl cyclase, influencing numerous transcription factors and potassium channels

CB2

the receptor which is more localized, specifically to immune cells

anandamide, 2-AG

the two endogenous ligands for CB1 and CB2