Top 200 Drug Interactions/Contraindications (1-200)

Lansoprazole

Interactions: 30 min after sucrafate, theophylline

Metoclopramide

Interactions: Alcohol, CNS depressants, cyclosporine, digoxin, succinylcholine Contraindications: pheochromocytoma, GI hemorrhage, mechanical obstruction/perforation, epilepsy

Topiramate

Interactions: Alcohol, CNS depressants, estrogens, metformin, phenytoin, carbamazepine, hydrochlorothiazide, valproic acid

Isosorbide

Interactions: Alcohol, vasodilators, Ca2+ channel blockers Contraindications: Nitrate hypersensitivity, hypotension

Baclofen

Interactions: CNS depressants Contraindications: Sensitivity, phenylalanine probs

Glyburide

Interactions: Dicumarol, chloramphenicol, alcohol, MAOI, salicylates, thiazide diuretics, rifampin Contraindications: Juvenile, unstable DM; caution in renal/hepatic impairment, thyroid function

Amitriptyline

Interactions: Dicumarol, clonidine, guanethidine, fluoxetine, symmpathomimetics, MAOIs, alcohol, CNS depressants, cimetidine Contraindications: 14 days of MAOIs

Sitagliptin

Interactions: Digoxin Contraindications: Renal insufficiency

Insulin Glargine

Interactions: Everything Cautions: Small changes in dose

Triamterene w/ HCTZ

Interactions: Glycosides, diazoxide, lithium, potassium-sparing diuretics, potassium supplements, ACEI Contraindications: Anuria, hyperkalemia, sulfonamide sensitivity, potassium-sparing diuretics

Lisinopril w/ Hydrochlorothiazide

Interactions: Indomethacin, allopurinol, potassium supplements Contraindications: Angioedema, sulfonamide hypersensitivity

Amlodipine w/ Benazepril

Interactions: Indomethacin, capsaicin, K sparing products, lithium, simvastatin Contraindications: Second/third trimesters Pregnancy Category D

Enalapril

Interactions: Indomethacin, capsaicin, diuretics (K-sparing) Contraindications: Pregnancy, nursing mothers Pregnancy Category D

Ramipril

Interactions: Indomethacine, capsaicin, K+sparing diuretics, K+ supplements, lithium Caution: Pregnancy/nursing, impaired renal function, collagen vascular disease, aortic stenosis

Duloxetine

Interactions: MAOI, CYP1A2 & CYP2D6 inhibitors, antidepressants Contraindications: MAOI, narrow-angle glaucoma

Phentermine, CIV

Interactions: MAOI, FENFLURAMINE, DEXFLENFLURAMINE Contraindications: Advanced ateriosclerosis, CVD, HTN, hyperthyroidism, glaucoma, agitation, hx of drug abuse

Fluoxetine

Interactions: MAOI, THIORIDAZINE, tryptophan, sumatriptan, aspirin, NSAIDS Contraindications: MAOI, thioridazine

Venlafaxine

Interactions: MAOI, antihistamines, aspirin, NSAIDS

Lisdexamfetamine, CII

Interactions: MAOI, furazolidone, sodium bicarb, antiHTN, tricyclics, haloperidol, lithium Contraindications: Advanced arteriosclerosis, symptomatic CVD, HTN, hyperthyroidism, glaucoma, agitation, hx of drug aabuse, 14 days of MAOI

Hydrocortisone

Interactions: None Contraindications: Hypersensitivity; Caution - dermatologic infections, HPA suppression

Benzonatate

Interactions: None Contraindications: Procaine, tetracaine allergy

Chlorhexidine

Interactions: None Contraindications: Supragingival calculus, stain oral surfaces

Hydroxyzine Pamoate

Interactions: Opioids, barbituates Contraindications: CNS depression, nursing mothers

Gemfibrozil

Interactions: Oral anticoagulants, LOVASTATIN Contraindications: hepatic or renal dysfunction, gallbladder disease

Amoxicillin w/ Clavulanate

Interactions: Oral contraceptives, bacteriostatic antibiotics, prebenecid Contraindications: Penicillin/cephalosporin sensitivity

Penicillin V Potassium

Interactions: Oral contraceptives, probenecid Contraindications: Allergy to penicillins, cephalosporins

Cephalexin

Interactions: Oral contraceptives, probenecid Contraindications: Penicillin/cephalosporin allergy

Fentanyl CII

Interactions: Phenothiazines, anesthetics, sedatives, hypnotics, alcohol, muscle relaxants, analgesics Contraindications: Fentanyl or adhesive sensitivity

Benztropine

Interactions: Phenothiazines, haloperidol Contraindications: <3 yo

Sucralfate

Interactions: Phenytoin, -floxacin, digoxin, tetracycline, penicillamine, theophylline Contraindications: Caution - Chronic renal failure, agents with aluminum

Insulin Detemir

Interactions: Steroids, danazol, sympathomimetic agents, oral contraceptives, thiazide diuretics, thyroid hormones, oral antidiabetic drugs, ACEI, MAOI Contraindications: Hypoglycemia, ketoacidosis

Fluticasone w/ Salmeterol

Interactions: Systemic corticosteroids, sympathomimetics, tricyclic antidepressants, MAOIs, B-blockers Contraindications: Primary treatment of status asthmaticus, LONG-ACTING BETA-2 AGONISTS

Quinapril

Interactions: Tetracycline, antacids, indomethacin, capsaicin, K+ sparing diuretics, K+ supplements, lithium, digoxin Caution: Pregnancy/nursing, collagen vascular disease, aortic stenosis

Finasteride

Interactions: Theophylline Contraindications: Women, children PREGNANCY CATEGORY X

Latanoprost

Interactions: Topical ophthalmic agents, wearing contact lenses (reinsert after 15 min) Contraindications: Latanoprost/benzalkonium chloride hypersensitivity, increasing pigment (melanosomes)

Clonidine

Interactions: Tricyclic antidepressants, beta-adrenergic blockers

Ranitidine

Interactions: WARFARIN, lidocaine Caution: Renal or hepatic impairment

Famotidine

Interactions: Warfarin Contraindications: Hypersensitivity

Amiodarone

Interactions: Warfarin, phenytoin, digoxin, quinidine, procainamide, disopyramide, fentanyl, lidocaine, grapefruit juice, st johns wart, phenytoin, B blockers, CCB Contraindications: cardiogenic shock, sinux bradycardia, second/third degree AV block

Omeprazole

No major interactions or contraindications

Diclofenac

Interactions: Aspirin, methotrexate, digoxin, cyclosporine, lithium, diuretics, ACEIs, warfarin, NSAIDS Contraindications: NSAID allergy, pain after CABG

Ibuprofen

Interactions: Aspirin, probenecid, lithium, beta-blockers, loop diuretics Contraindications: NSAID hypersensitivity

Verapamil

Interactions: B-BLOCKERS, prazosin, DIGITALIS glycosides, carbamazepine Contraindications: L. ventricular dysfunction, hypotension (SBP<90 mmHg), cardiogenic shock, sick sinus syndrome, second/third-degree AV block, severe congestive heart failure

Hydralazine

Interactions: B-blockers Contraindications: CAD, valvular rheumatic heart disease; Caution - CVA, impaired renal funciton

Minocycline

Interactions: Bactericidal ABX, oral contraceptives, digoxin, aluminum, bismuth, calcium, magnesium, zinc, iron salts, urinary alkalinizer, METHOXYFLURANE Contraindications: < 8 yo, pregnancy/lactation, impaired renal function Pregnancy Category D

Doxycycline

Interactions: Bactericidal antibiotics, oral contraceptives, digoxin, aluminum, bismuth, Ca2+, Mg2+, zinc, iron salts, urinary alkalinizers, METHOXYFLURANE Contraindications: Use < 8 yo, impaired renal function

Metronidazole

Interactions: Barbiturates, disulfiram, WARFARIN, alcohol Contraindications: Trichomoniasis

Conjugated Estrogens

Interactions: Barbiturates, rifampin, hydantoins, corticosteroids Contraindications: Breast cancer, estrogen-dependent neoplasia, pregnancy, thrombophlebitis, thromboembolic disorders PREGNANCY CATEGORY X

Niacin

Interactions: Bile acid sequestrants, HMG CoA reductase inhibitors Contraindications: Hepatic dysfunction, active peptic ulcer disease, arterial bleeding

Warfarin

Contraindications: Alcohol, allopurinol, amiodarone, adrenocortical steroids, methyltetrazolethiol, cephalosporins, chloral hydrate, cimetidine, clofibrate, dextrothyroxine, disulfiram, erthromycin, glucagon, metronidazole, phenylbutazones, quinidine, salicylates, sulfamethoxazole/trimethoprim, sulfinpyrazone, thyroid Contraindications: Hemorrhagic tendancies, blood dyscrasias, surgery, bleeding, eclampsia, spinal puncture, lumbar block, malignant hypertension PREGNANCY CATEGORY X

Levetiracetam

Contraindications: Impaired renal function, withdraw slowly

Amoxicillin

Contraindications: Penicillin or cephalosporin allergy

Prednisone

Contraindications: Systemic fungal infections, immunization w/ live vaccines

Nifedipine

Interactions: Cimetidine, grapefruit juice, quinidine Contraindications: Surgery w/ fentanyl

Fluticasone Propionate

Interactions: Systemic corticosteroids Contraindications: Tx of status asthmaticus

Dicyclomine

Interactions: Phenothiazine, haloperidol Contraindications: UTI, intestinal obstruction/atropy, unstable CV status, <6 mon, glaucoma

Butalbital, APAP, Caffeine

Interactions: A/C, corticosteroids, estrogen, doxycycline, quinidine, B-Blockers, methoxyflurane, sulfinpyrazone, alcohol, CNS depressants Contraindications: Porphyria; Caution - increased ICP, head injury, hepatic/renal impairment, addison's disease, hypothyroidism

Celecoxib

Interactions: ACEI, lithium, fluconazole, WARFARIN Contraindications: Asthma, urticaria, sulfonamide/aspirin/NSAID sensitivity, peri-operative pain

Clonazepam CIV

Interactions: ALCOHOL, CNS depressants Contraindications: Benzodiazepine sensitivity, liver disease, <6 months old, glaucoma

Cyclobenzaprine

Interactions: ALCOHOL, CNS depressants, guanethidine Contraindications: congestive heart failure, hyperthyroidism, cardiac arrhythmia, conductive disturbances, MI

Trazodone

Interactions: ALCOHOL, CNS depressants, phenytoin, grapefruit juice, CYP3A4 inhibitors

Phenytoin

Interactions: AMIODARONE, CHLORAMPHENICOL, CIMETIDINE, DISULFRAM, ISONIAZID, ORAL ANTICOAG, SULFONAMIDES, FLUCONAZOLE, TRIMETHOPRIM, ANTINEOPLASTICS, CARBAMAZEPINE, RIFAMPIN, SUCRALFATE, DISOPYRAMIDE, THEOPHYLLINES, ORAL CONTRACEPTIVES

Ciprofloxacin

Interactions: ANTACIDS, IRON SALTS, THEOPHYLLINE, Contraindications: Quinolone sensitivity, children, adolescents, or pregnant women

Hydrocodone with Acetaminophen, CII

Interactions: Alcohol, CNS depressants

Carisoprodol, CIV

Interactions: Alcohol, CNS depressants Contraindications: Acute intermittent porphyria

Benazepril

Interactions: Aliskiren, indomethacin, capsaicin, K sparing diuretics, K supplements, trimethoprim, lithium Contraindications: ALISKIREN Pregnancy Category D

Tamsulosin

Interactions: Alpha blockers, cimetidine Contraindications: Prostate carcinoma screening

Cefdinir

Interactions: Aluminum/magnesium antacids, iron, probenecid Contraindications: Penicillin/cephalosporin allergy; Caution - renal impairment, 2 hours from antacids/iron supplements

Furosemide

Interactions: Aminoglycosides, electrolyte disturbances (digitalis) Contraindications: Anuria, severe electrolyte depletion

Folic Acid

Interactions: Aminosalicylic acid, oral contraceptives, sulfasalazine, dihydrofolate reductase inhibitors, phenytoin Contraindications: Pernicious/megaloblastic anemia where vit B12 is not deficient

Allopurinol

Interactions: Ampicillin-induced skin rash, thiopurines, chlorpropamide

Gabapentin

Interactions: Antacids Contraindications: Abrupt discontinuation

Azithromycin

Interactions: Antacids, food Contraindications: Macrolide or ketolide allergy, prolonged QT-interval

Levofloxacin

Interactions: Antacids, sucralfate, iron, QUINIDINE, PROCAINAMIDE, AMIODARONE, SOTALOL, NSAIDS Contraindications: Quinolone sensitivity

Haloperidol

Interactions: Anticholinergics, LITHIUM, carbamazepine Contraindications: Severe CNS depression, parkinsonism, comatose states

Promethazine w/ Codeine CIV

Interactions: Anticholinergics, alcohol, CNS depressants, metrizamide, barbiturates Contraindications: Hypersensitivity, phenothiazines, LRTI

Methylprednisolone

Interactions: Anticholinesterases, barbituates, rifampin, hydantoins, estrogens, ketoconazole Contraindications: Systemic fungal infections

Doxazosin

Interactions: Antihypertensive agents, diuretics Caution: Liver impairment, syncope

Terazosin

Interactions: Antihypertensives, diuretics Contraindications: syncope

Hydromorphone, CII

Interactions: Antipsychotics, anesthetics, sedatives, hypnotics, alcohol, skeletal muscle relaxants, 14 days of MAOI, anticholinergics Contraindications: Respiratory depression, acute/severe bronchial asthma, not opioid-tolerant (ER), paralytic ileus (ER), GI obstruction/narrowing (ER)

Meloxicam

Interactions: Aspirin Contraindications: NSAID/Aspirin hypersensitivity, renal disease, ulcer disease GI bleeding

Divalproex

Interactions: Aspirin, carbamazepine, dicumarol, phenobarbital, phenytoin, clonazepam Contraindications: Hepatic disease

Diclofenac

Interactions: Aspirin, methotrexate, digoxin, cyclosporine, lithium, diuretics, ACEI, warfarin, SSRI/SNRI Contraindications: NSAID hypersenstivity, pain following CABG, GI toxicity

Levonorgestrel w/ Ethinyl Estradiol

Interactions: Broad spectrum ABX, barbituates, rifampin, St. John's Wort Contraindications: Thromboembolic disorders, breast carcinoma/estrogen dependent neoplasia, pregnancy, undiagnosed abnomal genital bleeding, benign/malignant liver tumors, CVA, CVD PREGNANCY CATEGORY X

Norgestimate & Ethinyl Estradiol

Interactions: Broad spectrum antibiotics (ampicillin, amoxicillin, metronidazole, tetracycline) Contraindicated: Thromboembolic disorders, breast carcinoma, estrogen dependent neoplasia, pregnancy, benign/malignant liver tumors, abnormal genital bleeding, cerebral or cardiovascular disease PREGNANCY CATEGORY X

Atenolol

Interactions: CLONIDINE, VERAPAMIL, lidocaine Contraindicaitons: Sinus bradycardia, heart block, cardiogenic shock, cardiac failure

Hydroxyzine Hydrochloride

Interactions: CNS depressants Contraindications: Early pregnancy

Alprazolam, CIV

Interactions: CNS depressants Contraindications: Hypersensitivity to benzodiazepines, narrow-angle glaucoma

Zolpidem, CIV

Interactions: CNS depressants Contraindications: Hypersensitivity, hypnotic agents

Temazepam CIV

Interactions: CNS depressants Contraindications: Pregnancy, BZDP sensitivity

Methocarbamol

Interactions: CNS depressants Contraindications: Pregnancy, nursing mothers, injectable with epilepsy

Tramadol, CIV

Interactions: CNS depressants Contraindications: alcohol, hypnotics, opioids, psychotropic drugs & dependence

Phenobarbital, CIV

Interactions: CNS depressants, ALCOHOL, VPA, ANTICOAGULANTS, b-blockers, estrogens, steroids, doxycycline Contraindications: Barbituate hypersensitivity, porphyria, pregnancy

Oxycodone w/ Acetaminophen CII

Interactions: CNS depressants, ALCOHOL, hydantoins, sulfinpyrazone

Mirtazapine

Interactions: CNS depressants, MAO INHIBITORS, aspirin, NSAIDS Contraindications: Antidepressants, abrupt discontinuation

Acetaminophen w/ Codeine, CIII

Interactions: CNS depressants, alcohol, hydantoins, sulfinpyrazone Contraindications: Caution - Intracranial pressure, head injury, hepatic/renal impairement

Diazepam CIV

Interactions: CNS depressants, cimetidine, grapefruit juice Contraindications: Myasthenia gravis, respiratory insufficiency, hepatic insufficiency, sleep apnea, children<6 yo, narrow-angle glaucoma, open-angle glaucoma

Olanzapine

Interactions: CNS depressants, omeprazole, rifampin, fluvoxamine, activated charcoal, carbamazepine Contraindications: DEMENTIA-RELATED PSYCHOSIS

Quetiapine

Interactions: CNS depressants, phenytoin, thioridazine Contraindications: DEMENTIA-RELATED PSYCHOSIS

Lorazepam CIV

Interactions: CNS depressants, probenecid, valproate Contraindicated: benzodiazepine hypersensitivity, narrow-angle glaucoma

Rosuvastatin

Interactions: CYCLOSPORINE, warfarin, gemfibrozil, ANTACIDS Contraindications: active liver disease, pregnancy/lactation PREGNANCY CATEGORY X

Buprenorphine w/ Naloxone CIII

Interactions: CYP 3A4 inhibitors/inducers, BZDP Contraindications: COPD, cor pulmonale, hypoxia, resp. depression

Nebivolol

Interactions: CYP2D6 (paroxetine, fluoxetine, propafenone, quinidine), digoxin, CCB Contraindications: Bradycardia, heart block > 1st degree, cardiogenic shock, decompensated CHF, sick sinus syndrome, severe hepatic impairment

Tiotropium

Interactions: CYP2D6/3A4 inhibitors Contraindications: Atropine sensitivity

Tolterodine

Interactions: CYP3A4 (azoles, erythromycin, clarithromycin, cyclosporine, vinblastine) Contraindications: Urinary retention, gastric retention, uncontrolled narrow-angle glaucoma, hypersensitivity

Simvastatin

Interactions: CYP3A4 Inhibitors, grapefruit Contraindications: Hypersensitivity, pregnancy/lactation, liver disease, strong CYP3A4 agents, excessive alcohol PREGNANCY CATEGORY X

Solifenacin

Interactions: CYP3A4 inh (azole, ritonavir, clarithromycin) Contraindications: Urinary retention, gastric retention, uncontrolled narrow-angle glaucoma; Caution - bladder outflow obstruction, QT prolongation

Alendronte

Interactions: Calcium, antacids, aspirin, NOTHING W/IN 30 MIN OF DOSE Contraindications: Esophageal abnormalities, cannot sit/stand upright for 30 min, hypocalcemia

Spironolactone

Interactions: Captopril, K+ sparing medications, K+ supplements, DIGITALIS Contraindications: Anuria, acute renal insufficiency, renal impairment, hyperkalemia, sulfonamide/spironolactone sensitivity

Lithium

Interactions: Carbamazepine, iodides, NSAIDS, ACEI, thiazides, urinary alkalinizers, HALOPERIDOL Contraindications: Renal/cardiovascular disease, severe debilitation, dehydration, Na depletion; Caution - diuretics, ACEI

Ziprasidone

Interactions: Carbamazepine, ketoconazole, dofetilide, sotalol, quinidine, Class Ia and III antiarrhythmics, -floxacin Contraindications: DEMENTIA-RELATED PSYCHOSIS, QT prolongation, recent MI, uncompensated HR, drugs prolonging QT interval; Caution - hypokalemia, hypomagnesemia, bradycardia

Oxcarbazepine

Interactions: Carbamazepine, phenobarbital, phenytoin, VPA, verapamil, estrogens/progestins Contraindications: Hypersensitivity to either carbamzepine or oxcarbazepine, stevens-johnson, toxic epidermal necrolysis, hyponatremia

Memantine

Interactions: Carbonic anhydrase inhibitors, sodium bicarb Contraindications: Hypersensitivity

Glipizide

Interactions: Chloramphenicol, alcohol, MAOIs, phenylbutazones, salicylates, sulfonamides, thiazide diuretics Contraindications: Juvenile, unstable or complicated diabetes mellitus, allergy to sulfa drugs, diabetic ketoacidosis w or w/o coma

Losartan w/ HCTZ

Interactions: Cimetidine, phenobarbital, DIGITALIS, diazoxide, NSAIDS, alcohol, barbituates, narcotics, cholestyramine Contraindications: Volume-depleted, pregnant, anuria, sulfonamide sensitivity, pregnancy

Pramipexole

Interactions: Cimetidine, ranitidine, CCB, quinidine/quinine Contraindications: Orthostatic hypotension, renal dysfunction

Cyanocobalamin

Interactions: Colchine, alcohol, antibiotics Contraindications: Early Lebers disease

Insulin Aspart, rDNA origin

Interactions: Corticosteroids, diltiazem, dobutamine, epinephrine, contraceptives, thiazides, thyroid, tobacco, alcohol, b-blockers, MAOIs Contraindications: Hypoglycemia

Sulfamethoxazole w/ Trimethoprim

Interactions: Cyclosporine, anticoagulants Contraindictions: Infants < 2 months, pregnancy/nursing, sulfa allergies, megaloblastic anemia

Diltiazem

Interactions: Cyclosporine, cimetidine, carbamazepine Contraindications: Sick sinus syndrome, second/third-degree AV block

Digoxin

Interactions: DIURETICS, AMIODARONE, QUINIDINE, PROPAFENONE, ERYTHROMYCIN, CYCLOSPORINE, TETRACYCLINES, VERAPAMIL Contraindications: V. fibb

Testosterone, CIII

Interactions: Decreased insulin requirements, anticoagulants, corticosteroids Contraindications: Males with carcinoma of breast/prostate, BPH, prostate cancer; Caution - CHF, hyperlipidemia PREGNANCY CATEGORY X

Esomeprazole

Interactions: Diazepam, ketoconazole, digoxin, cyanocobalamin, ampicillin, iron salts

Sotalol

Interactions: Disopyramide, quinidine, procainamide, amiodarone, CCB, reserpine, antacids Contraindications: Bronchial asthma, sinus bradycardia, second/third degree AV block, long QT syndromes, cardiogenic shock, uncontrolled CHF

Hydrochlorothiazide

Interactions: Electrolyte disturbances (digitalis) Contraindications: Anuria, sulfonamide hypersensitivity

Codeine w/ Guaifenesin, CIV

Interactions: Elevate VMA test, alcohol, CNS depressants Contraindications: Persistent cough; Caution - increased ICP, head injury, Addison's disease, hypothyroidism

Nitroglycerin

Interactions: Ergot, heparin, SILDENAFIL Contraindications: Intolerant to organic nitrates, anemia, closed-angle glaucome, postural hypotension, intracranial pressure, early MI, hypotension, hypovolemia, pericardial tamponade

Sumatriptan

Interactions: Ergot-containing drugs, MAOI Contraindications: Do not give IV, IHD, Prinzmetal's angina, uncontrolled hypertension, migraines

Cefuroxime

Interactions: Estrogen oral contraceptives, probenecid, urine glucose tests (false +) Contraindications: Penicillin/cephalosporin allergy; Caution - renal impairment

Metformin

Interactions: Furosemide, Cimetidine, Nifedipine, Alcohol Contraindications: Impaired renal function (male>1.5, female>1.4)

Lovastatin

Interactions: GEMFIBROZIL, grapefruit juice Contraindications: Pregnancy/lactation, active liver disease, elevated serum transaminases PREGNANCY CATEGORY X

Pravastatin

Interactions: Gemfibrozil, erythromycin, immunosuppressive agents Contraindications: Pregnancy/lactation, acute liver disease PREGNANCY CATEGORY X

Ezetimibe

Interactions: Gemfibrozil, fenofibrate, cholestyramine Contraindications: Hepatic insufficiency

Atorvastatin

Interactions: Grapefruit Contraindications: Pregnancy/lactation, liver disease, excessive alcohol PREGNANCY CATEGORY X

Carbidopa w/ Levodopa

Interactions: Hydantoins, pyridoxine, MAOI Contraindications: Narrow-angle glaucoma, skin lesion/melanoma, MAOI use or w/in 14 days; Caution - psychosis, cardiovascular/pulmonary disease, peptic ulcer, bronchial asthma

Lisinopril

Interactions: K supplements Contraindications: History of angioedema from ACE inhibitor treatment

Potassium Chloride

Interactions: K-sparing diuretics, K-containing medications/salt substitutes Contraindications: Hyperkalemia

Dexlansoprazole

Interactions: Ketoconazole, ampicillin, iron salts, digoxin, tacrolimus Contraindications: Hypersensitivity, long-term use (osteoporosis)

Guanfacine

Interactions: Ketoconazole, rifampin, antihypertensives, CNS depressants, VPA Caution: Severe coronary insufficiency, recent MI, CVD, renal/hepatic failure

Risperidone

Interactions: Levodopa, carbamazepine, fluoxetine, clozapine Contraindications: DEMENTIA-RELATED PSYCHOSIS, neuroleptic malignant syndrome

Insulin Lispro, rDNA origin

Interactions: Lots Contraindications: Hypoglycemia

Albuterol

Interactions: MAO inhibitors Contraindications: Hypersensitivity

Citalopram

Interactions: MAO inhibitors Contraindications: May increase suicidal thoughts in children, teenagers, w/in 14 days of MAO inhibitors

Sertraline

Interactions: MAO inhibitors, pimozide Contraindications: May increase suicidal thoughts in children, teenagers, w/in 14 days of MAO inhibitors, tasks requiring alertness

Methadone CII

Interactions: MAOI, rifampin, pentazocine, CNS depressants Contraindications: Injection use, acute asthma attack, COPD, resp. depression

Escitalopram

Interactions: MAOIs, CYP3A4 inhibitors, cimetidine, aspirin, NSAIDs Contraindications: 14 days of MAOIs

Bupropion

Interactions: MAOIs, L-dopa, alcohol, tricyclic antidepressants, paroxetine, fluoxetine, sertraline, haloperidol, risperidone, thioridazine, metoprolol (CYP2D6) Contraindications: Seizure disorder, history of bulimia or anorexia nervosa, 14 days of MAOIs

Amphet w/ Dextroamphet CII

Interactions: MAOIs, furazolidone, sodium bicarbonate, antihypertensives Contraindications: Advanced arteriosclerosis, cardiovascular disease, moderate hypertension, hyperthyroidism, agitated states, glaucoma, 14 days of MAOIs

Buspirone

Interactions: MAOIs, grapefruit juice

Paroxetine

Interactions: MAOIs, phenytoin, phenobarbital, cimetidine, WARFARIN, procyclidine, aspirin, NSAIDs Contraindications: Pregnancy, 14 days of MAOIs

Methylphenidate CII

Interactions: MAOIs, phenytoin, phenobarbital, warfarin, SSRIs, clonidine Contraindications: Anxiety, tension, agitation, glaucoma, motor tics, family history of Tourette's syndrome, 14 days of MAOIs

Nitrofurantoin

Interactions: Magnesium Contraindications: Anuria, oliguria, impaired renal function, infants < 1 mo; Caution - G6P deficiency, peripheral neuropathy, pulmonary disease

Oseltamivir

Interactions: NONE Contraindications: Not a substitute for influenza vaccine

Valsartan

Interactions: NSAIDS Contraindications: Pregnancy

Clopidogrel

Interactions: NSAIDS, CYP2C9 metabolites, OMEPRAZOLE, esomeprazole Contraindications: Bleeding

Methotrexate

Interactions: NSAIDS, phenytoin, sulfonamides, mercaptopurine, ABX, penicillin, theophylline Contraindications: Only indicated for life-threatening neoplastic disease, patients with psoriasis or RA, severe recalcitrant, disabling disease not responsive to other forms of therapy; alcoholism, liver disease, immunodeficiency syndrome, pre-existing blood dyscrasias PREGNANCY CATEGORY X

Mupirocin

Interactions: Nasal ointments Contraindications: Not for opthalamic use

Clindamycin

Interactions: Neuromuscular blocking agents, clindamycin, erythromycin Contraindications: Severe/persistent diarrhea

Losartan

Interactions: No major interactions

Pantoprazole

Interactions: No major interactions Contraindications: Hypersensitivity to components

Ondansetron

Interactions: None

Hydroxychloroquine

Interactions: None Contraindications: Hypersensitivity, visual disturbances (4-aminoquinolines), long-term use in children

Olmesartan

Interactions: None Contraindications: Hypersensitivity, volume depleted

Nystatin

Interactions: None Contraindications: Systemic mycoses

Glimepiride

Interactions: None; CYP450 2C9 Contraindications: Diabetic ketoacidosis w/ or w/o coma, aware of hypoglycemia

Naproxen

Interactions: Oral anticoag, lithium, methotrexate, NSAIDS Contraindications: NSAID sensitivity

Carbamazepine

Interactions: Oral anticoag, valproic acid, cimetidine, diltiazem, fluoxetine, verapamil, MACROLIDES, hydantoins, doxycycline, haloperidol, grapefruit juice Contraindications: Bone marrow depression, MAO w/in 14 days

Levothyroxine

Interactions: Oral anticoagulants Contraindications: Uncorrected adrenal cortical insufficiency, uncorrected thyrotoxicosis, acute MI

Mometasone Furoate

Interactions: Oral corticosteroids Contraindications: Caution - pregnancy/lactation, TB, fungal/bacterial/systemic/viral infections

Montelukast

Interactions: Phenobarbital

Oxycodone CII

Interactions: Phenothiazines, anesthetics, hypnotics, sedatives, alcohol, muscle relaxants Contraindications: Respiratory depression, bronchial asthma, paralytic ileus

Morphine CII

Interactions: Phenothiazines, anesthetics, sedatives, hypnotics, alchol, muscle relaxants, analgesics Contraindications: Respiratory depression, acute/sevre bronchial asthma, paralytic ileus

Donepezil

Interactions: Phenytoin, carbamazepine, phenobarbital, rifampin, dexamethasone, ketoconazole, quinidine Contraindications: Donepezil/piperidine derivative hypersensitivity

Lamotrigene

Interactions: Phenytoin, carbamazepine, phenobarbital, rifampin, valproic acid, ORAL CONTRACEPTIVES

Acyclovir

Interactions: Probenecid Contraindications: Hypersensitivity, renal impairment, dehydration

Valacyclovir

Interactions: Probenecid Contraindications: Renal impairment, dehydration

Rivaroxaban

Interactions: RIFAMPIN, PHENYTOIN, ST JOHNS WART, CARBAMAZEPINE, KETOCONAZOLE, RITONAVIR, CLARITHROMYCIN, enoxaparin, warfarin, aspirin, clopidogrel, NSAIDS Contraindications: Active pathological bleedings, hypersensitivity

Carvedilol

Interactions: Rifampin, cimetidine, CYP2C9 inhibitors Contraindications: Cardiac failure, asthma, AV block, sick sinus syndrome, cardiogenic shock, bradycardia Caution: Hepatic dysfunction, diabetics

Amlodipine

Interactions: Simvastatin

Ropinirole

Interactions: Smoking, omeprazole, ciprofloxacin, estrogens, dopamine antagonists Contraindications: Syncope, postural hypotension

Valsartan w/ HCTZ

Interactions: Sulfonylureas, DIGITALIS-induced arrhythmia from electrolyte disturbances, diazoxide, lithium, NSAIDS Contraindications: Anuria, pregnancy, salt-depleted/volume depleted PREGNANCY CATEGORY D (2/3 trimester)

Ipratropium w/ Albuterol

Interactions: Sympathomimetics, tricyclic antidepressants, MAOIs, non-potassium sparing diuretics Contraindications: Combivent-soybean or peanut sensitivity

Fluticasone Propionate

Interactions: Systemic Corticosteroids Cautions: Pregnant/lactating women, multiple infections

Triamcinolone

Interactions: Systemic corticosteroids Contraindications: Sensitivity

Budesonide & Formoterol

Interactions: Systemic corticosteroids, sympathomimetics, TCAs, MAOIs, B-blockers, CYP3A4 inhibitors Contraindications: Primary treatment of staticus asthmaticus, B2-AGONIST INCREASES RISK OF ASTHMA-RElATED DEATH

Propranolol

Interactions: Theophyllines, clonidine, rifampin, NSAIDS, VERAPAMIL, epinephrine, prazosin Contraindications: Cardiogenic shock, bronchial asthma, sinus bradycardia, >1st degree heart block, CHF

Metoprolol Tartrate

Interactions: Verapamil Contraindications: Sinus bradycardia, heart block>1st degree, cardiogenic shock, CHF, cardiac failure, HR<45 bpm, SBP<100 mmHg Cautions: Diabetes

Metoprolol Succinate

Interactions: Verapamil Contraindications: Sinus bradycardia, heart block>1st degree, cardiogenic shock, HF, sick sinus syndrome Cautions: Diabetes

Fenofibrate

Interactions: WARFARIN, HMG-CoA reductase inhibitors, cholestyramine Contraindications: Hepatic or renal dysfunction, primary biliary cirrhosis, preexisting gallbladder disease

Fluconazole

Interactions: Warfarin, phenytoin, midazolam, VORICONAZOLE, cyclosporine, antidiabetic meds, rifampin

Pioglitazone

Interactions: oral contraceptives, azoles, gemfibrozil, rifampin Contraindications: Class III/IV CHF, Type 1 DM, resumption of ovulation; Caution - hepatic dysfunction