Top 200 Drug Interactions/Contraindications (1-200)
Lansoprazole
Interactions: 30 min after sucrafate, theophylline
Metoclopramide
Interactions: Alcohol, CNS depressants, cyclosporine, digoxin, succinylcholine Contraindications: pheochromocytoma, GI hemorrhage, mechanical obstruction/perforation, epilepsy
Topiramate
Interactions: Alcohol, CNS depressants, estrogens, metformin, phenytoin, carbamazepine, hydrochlorothiazide, valproic acid
Isosorbide
Interactions: Alcohol, vasodilators, Ca2+ channel blockers Contraindications: Nitrate hypersensitivity, hypotension
Baclofen
Interactions: CNS depressants Contraindications: Sensitivity, phenylalanine probs
Glyburide
Interactions: Dicumarol, chloramphenicol, alcohol, MAOI, salicylates, thiazide diuretics, rifampin Contraindications: Juvenile, unstable DM; caution in renal/hepatic impairment, thyroid function
Amitriptyline
Interactions: Dicumarol, clonidine, guanethidine, fluoxetine, symmpathomimetics, MAOIs, alcohol, CNS depressants, cimetidine Contraindications: 14 days of MAOIs
Sitagliptin
Interactions: Digoxin Contraindications: Renal insufficiency
Insulin Glargine
Interactions: Everything Cautions: Small changes in dose
Triamterene w/ HCTZ
Interactions: Glycosides, diazoxide, lithium, potassium-sparing diuretics, potassium supplements, ACEI Contraindications: Anuria, hyperkalemia, sulfonamide sensitivity, potassium-sparing diuretics
Lisinopril w/ Hydrochlorothiazide
Interactions: Indomethacin, allopurinol, potassium supplements Contraindications: Angioedema, sulfonamide hypersensitivity
Amlodipine w/ Benazepril
Interactions: Indomethacin, capsaicin, K sparing products, lithium, simvastatin Contraindications: Second/third trimesters Pregnancy Category D
Enalapril
Interactions: Indomethacin, capsaicin, diuretics (K-sparing) Contraindications: Pregnancy, nursing mothers Pregnancy Category D
Ramipril
Interactions: Indomethacine, capsaicin, K+sparing diuretics, K+ supplements, lithium Caution: Pregnancy/nursing, impaired renal function, collagen vascular disease, aortic stenosis
Duloxetine
Interactions: MAOI, CYP1A2 & CYP2D6 inhibitors, antidepressants Contraindications: MAOI, narrow-angle glaucoma
Phentermine, CIV
Interactions: MAOI, FENFLURAMINE, DEXFLENFLURAMINE Contraindications: Advanced ateriosclerosis, CVD, HTN, hyperthyroidism, glaucoma, agitation, hx of drug abuse
Fluoxetine
Interactions: MAOI, THIORIDAZINE, tryptophan, sumatriptan, aspirin, NSAIDS Contraindications: MAOI, thioridazine
Venlafaxine
Interactions: MAOI, antihistamines, aspirin, NSAIDS
Lisdexamfetamine, CII
Interactions: MAOI, furazolidone, sodium bicarb, antiHTN, tricyclics, haloperidol, lithium Contraindications: Advanced arteriosclerosis, symptomatic CVD, HTN, hyperthyroidism, glaucoma, agitation, hx of drug aabuse, 14 days of MAOI
Hydrocortisone
Interactions: None Contraindications: Hypersensitivity; Caution - dermatologic infections, HPA suppression
Benzonatate
Interactions: None Contraindications: Procaine, tetracaine allergy
Chlorhexidine
Interactions: None Contraindications: Supragingival calculus, stain oral surfaces
Hydroxyzine Pamoate
Interactions: Opioids, barbituates Contraindications: CNS depression, nursing mothers
Gemfibrozil
Interactions: Oral anticoagulants, LOVASTATIN Contraindications: hepatic or renal dysfunction, gallbladder disease
Amoxicillin w/ Clavulanate
Interactions: Oral contraceptives, bacteriostatic antibiotics, prebenecid Contraindications: Penicillin/cephalosporin sensitivity
Penicillin V Potassium
Interactions: Oral contraceptives, probenecid Contraindications: Allergy to penicillins, cephalosporins
Cephalexin
Interactions: Oral contraceptives, probenecid Contraindications: Penicillin/cephalosporin allergy
Fentanyl CII
Interactions: Phenothiazines, anesthetics, sedatives, hypnotics, alcohol, muscle relaxants, analgesics Contraindications: Fentanyl or adhesive sensitivity
Benztropine
Interactions: Phenothiazines, haloperidol Contraindications: <3 yo
Sucralfate
Interactions: Phenytoin, -floxacin, digoxin, tetracycline, penicillamine, theophylline Contraindications: Caution - Chronic renal failure, agents with aluminum
Insulin Detemir
Interactions: Steroids, danazol, sympathomimetic agents, oral contraceptives, thiazide diuretics, thyroid hormones, oral antidiabetic drugs, ACEI, MAOI Contraindications: Hypoglycemia, ketoacidosis
Fluticasone w/ Salmeterol
Interactions: Systemic corticosteroids, sympathomimetics, tricyclic antidepressants, MAOIs, B-blockers Contraindications: Primary treatment of status asthmaticus, LONG-ACTING BETA-2 AGONISTS
Quinapril
Interactions: Tetracycline, antacids, indomethacin, capsaicin, K+ sparing diuretics, K+ supplements, lithium, digoxin Caution: Pregnancy/nursing, collagen vascular disease, aortic stenosis
Finasteride
Interactions: Theophylline Contraindications: Women, children PREGNANCY CATEGORY X
Latanoprost
Interactions: Topical ophthalmic agents, wearing contact lenses (reinsert after 15 min) Contraindications: Latanoprost/benzalkonium chloride hypersensitivity, increasing pigment (melanosomes)
Clonidine
Interactions: Tricyclic antidepressants, beta-adrenergic blockers
Ranitidine
Interactions: WARFARIN, lidocaine Caution: Renal or hepatic impairment
Famotidine
Interactions: Warfarin Contraindications: Hypersensitivity
Amiodarone
Interactions: Warfarin, phenytoin, digoxin, quinidine, procainamide, disopyramide, fentanyl, lidocaine, grapefruit juice, st johns wart, phenytoin, B blockers, CCB Contraindications: cardiogenic shock, sinux bradycardia, second/third degree AV block
Omeprazole
No major interactions or contraindications
Diclofenac
Interactions: Aspirin, methotrexate, digoxin, cyclosporine, lithium, diuretics, ACEIs, warfarin, NSAIDS Contraindications: NSAID allergy, pain after CABG
Ibuprofen
Interactions: Aspirin, probenecid, lithium, beta-blockers, loop diuretics Contraindications: NSAID hypersensitivity
Verapamil
Interactions: B-BLOCKERS, prazosin, DIGITALIS glycosides, carbamazepine Contraindications: L. ventricular dysfunction, hypotension (SBP<90 mmHg), cardiogenic shock, sick sinus syndrome, second/third-degree AV block, severe congestive heart failure
Hydralazine
Interactions: B-blockers Contraindications: CAD, valvular rheumatic heart disease; Caution - CVA, impaired renal funciton
Minocycline
Interactions: Bactericidal ABX, oral contraceptives, digoxin, aluminum, bismuth, calcium, magnesium, zinc, iron salts, urinary alkalinizer, METHOXYFLURANE Contraindications: < 8 yo, pregnancy/lactation, impaired renal function Pregnancy Category D
Doxycycline
Interactions: Bactericidal antibiotics, oral contraceptives, digoxin, aluminum, bismuth, Ca2+, Mg2+, zinc, iron salts, urinary alkalinizers, METHOXYFLURANE Contraindications: Use < 8 yo, impaired renal function
Metronidazole
Interactions: Barbiturates, disulfiram, WARFARIN, alcohol Contraindications: Trichomoniasis
Conjugated Estrogens
Interactions: Barbiturates, rifampin, hydantoins, corticosteroids Contraindications: Breast cancer, estrogen-dependent neoplasia, pregnancy, thrombophlebitis, thromboembolic disorders PREGNANCY CATEGORY X
Niacin
Interactions: Bile acid sequestrants, HMG CoA reductase inhibitors Contraindications: Hepatic dysfunction, active peptic ulcer disease, arterial bleeding
Warfarin
Contraindications: Alcohol, allopurinol, amiodarone, adrenocortical steroids, methyltetrazolethiol, cephalosporins, chloral hydrate, cimetidine, clofibrate, dextrothyroxine, disulfiram, erthromycin, glucagon, metronidazole, phenylbutazones, quinidine, salicylates, sulfamethoxazole/trimethoprim, sulfinpyrazone, thyroid Contraindications: Hemorrhagic tendancies, blood dyscrasias, surgery, bleeding, eclampsia, spinal puncture, lumbar block, malignant hypertension PREGNANCY CATEGORY X
Levetiracetam
Contraindications: Impaired renal function, withdraw slowly
Amoxicillin
Contraindications: Penicillin or cephalosporin allergy
Prednisone
Contraindications: Systemic fungal infections, immunization w/ live vaccines
Nifedipine
Interactions: Cimetidine, grapefruit juice, quinidine Contraindications: Surgery w/ fentanyl
Fluticasone Propionate
Interactions: Systemic corticosteroids Contraindications: Tx of status asthmaticus
Dicyclomine
Interactions: Phenothiazine, haloperidol Contraindications: UTI, intestinal obstruction/atropy, unstable CV status, <6 mon, glaucoma
Butalbital, APAP, Caffeine
Interactions: A/C, corticosteroids, estrogen, doxycycline, quinidine, B-Blockers, methoxyflurane, sulfinpyrazone, alcohol, CNS depressants Contraindications: Porphyria; Caution - increased ICP, head injury, hepatic/renal impairment, addison's disease, hypothyroidism
Celecoxib
Interactions: ACEI, lithium, fluconazole, WARFARIN Contraindications: Asthma, urticaria, sulfonamide/aspirin/NSAID sensitivity, peri-operative pain
Clonazepam CIV
Interactions: ALCOHOL, CNS depressants Contraindications: Benzodiazepine sensitivity, liver disease, <6 months old, glaucoma
Cyclobenzaprine
Interactions: ALCOHOL, CNS depressants, guanethidine Contraindications: congestive heart failure, hyperthyroidism, cardiac arrhythmia, conductive disturbances, MI
Trazodone
Interactions: ALCOHOL, CNS depressants, phenytoin, grapefruit juice, CYP3A4 inhibitors
Phenytoin
Interactions: AMIODARONE, CHLORAMPHENICOL, CIMETIDINE, DISULFRAM, ISONIAZID, ORAL ANTICOAG, SULFONAMIDES, FLUCONAZOLE, TRIMETHOPRIM, ANTINEOPLASTICS, CARBAMAZEPINE, RIFAMPIN, SUCRALFATE, DISOPYRAMIDE, THEOPHYLLINES, ORAL CONTRACEPTIVES
Ciprofloxacin
Interactions: ANTACIDS, IRON SALTS, THEOPHYLLINE, Contraindications: Quinolone sensitivity, children, adolescents, or pregnant women
Hydrocodone with Acetaminophen, CII
Interactions: Alcohol, CNS depressants
Carisoprodol, CIV
Interactions: Alcohol, CNS depressants Contraindications: Acute intermittent porphyria
Benazepril
Interactions: Aliskiren, indomethacin, capsaicin, K sparing diuretics, K supplements, trimethoprim, lithium Contraindications: ALISKIREN Pregnancy Category D
Tamsulosin
Interactions: Alpha blockers, cimetidine Contraindications: Prostate carcinoma screening
Cefdinir
Interactions: Aluminum/magnesium antacids, iron, probenecid Contraindications: Penicillin/cephalosporin allergy; Caution - renal impairment, 2 hours from antacids/iron supplements
Furosemide
Interactions: Aminoglycosides, electrolyte disturbances (digitalis) Contraindications: Anuria, severe electrolyte depletion
Folic Acid
Interactions: Aminosalicylic acid, oral contraceptives, sulfasalazine, dihydrofolate reductase inhibitors, phenytoin Contraindications: Pernicious/megaloblastic anemia where vit B12 is not deficient
Allopurinol
Interactions: Ampicillin-induced skin rash, thiopurines, chlorpropamide
Gabapentin
Interactions: Antacids Contraindications: Abrupt discontinuation
Azithromycin
Interactions: Antacids, food Contraindications: Macrolide or ketolide allergy, prolonged QT-interval
Levofloxacin
Interactions: Antacids, sucralfate, iron, QUINIDINE, PROCAINAMIDE, AMIODARONE, SOTALOL, NSAIDS Contraindications: Quinolone sensitivity
Haloperidol
Interactions: Anticholinergics, LITHIUM, carbamazepine Contraindications: Severe CNS depression, parkinsonism, comatose states
Promethazine w/ Codeine CIV
Interactions: Anticholinergics, alcohol, CNS depressants, metrizamide, barbiturates Contraindications: Hypersensitivity, phenothiazines, LRTI
Methylprednisolone
Interactions: Anticholinesterases, barbituates, rifampin, hydantoins, estrogens, ketoconazole Contraindications: Systemic fungal infections
Doxazosin
Interactions: Antihypertensive agents, diuretics Caution: Liver impairment, syncope
Terazosin
Interactions: Antihypertensives, diuretics Contraindications: syncope
Hydromorphone, CII
Interactions: Antipsychotics, anesthetics, sedatives, hypnotics, alcohol, skeletal muscle relaxants, 14 days of MAOI, anticholinergics Contraindications: Respiratory depression, acute/severe bronchial asthma, not opioid-tolerant (ER), paralytic ileus (ER), GI obstruction/narrowing (ER)
Meloxicam
Interactions: Aspirin Contraindications: NSAID/Aspirin hypersensitivity, renal disease, ulcer disease GI bleeding
Divalproex
Interactions: Aspirin, carbamazepine, dicumarol, phenobarbital, phenytoin, clonazepam Contraindications: Hepatic disease
Diclofenac
Interactions: Aspirin, methotrexate, digoxin, cyclosporine, lithium, diuretics, ACEI, warfarin, SSRI/SNRI Contraindications: NSAID hypersenstivity, pain following CABG, GI toxicity
Levonorgestrel w/ Ethinyl Estradiol
Interactions: Broad spectrum ABX, barbituates, rifampin, St. John's Wort Contraindications: Thromboembolic disorders, breast carcinoma/estrogen dependent neoplasia, pregnancy, undiagnosed abnomal genital bleeding, benign/malignant liver tumors, CVA, CVD PREGNANCY CATEGORY X
Norgestimate & Ethinyl Estradiol
Interactions: Broad spectrum antibiotics (ampicillin, amoxicillin, metronidazole, tetracycline) Contraindicated: Thromboembolic disorders, breast carcinoma, estrogen dependent neoplasia, pregnancy, benign/malignant liver tumors, abnormal genital bleeding, cerebral or cardiovascular disease PREGNANCY CATEGORY X
Atenolol
Interactions: CLONIDINE, VERAPAMIL, lidocaine Contraindicaitons: Sinus bradycardia, heart block, cardiogenic shock, cardiac failure
Hydroxyzine Hydrochloride
Interactions: CNS depressants Contraindications: Early pregnancy
Alprazolam, CIV
Interactions: CNS depressants Contraindications: Hypersensitivity to benzodiazepines, narrow-angle glaucoma
Zolpidem, CIV
Interactions: CNS depressants Contraindications: Hypersensitivity, hypnotic agents
Temazepam CIV
Interactions: CNS depressants Contraindications: Pregnancy, BZDP sensitivity
Methocarbamol
Interactions: CNS depressants Contraindications: Pregnancy, nursing mothers, injectable with epilepsy
Tramadol, CIV
Interactions: CNS depressants Contraindications: alcohol, hypnotics, opioids, psychotropic drugs & dependence
Phenobarbital, CIV
Interactions: CNS depressants, ALCOHOL, VPA, ANTICOAGULANTS, b-blockers, estrogens, steroids, doxycycline Contraindications: Barbituate hypersensitivity, porphyria, pregnancy
Oxycodone w/ Acetaminophen CII
Interactions: CNS depressants, ALCOHOL, hydantoins, sulfinpyrazone
Mirtazapine
Interactions: CNS depressants, MAO INHIBITORS, aspirin, NSAIDS Contraindications: Antidepressants, abrupt discontinuation
Acetaminophen w/ Codeine, CIII
Interactions: CNS depressants, alcohol, hydantoins, sulfinpyrazone Contraindications: Caution - Intracranial pressure, head injury, hepatic/renal impairement
Diazepam CIV
Interactions: CNS depressants, cimetidine, grapefruit juice Contraindications: Myasthenia gravis, respiratory insufficiency, hepatic insufficiency, sleep apnea, children<6 yo, narrow-angle glaucoma, open-angle glaucoma
Olanzapine
Interactions: CNS depressants, omeprazole, rifampin, fluvoxamine, activated charcoal, carbamazepine Contraindications: DEMENTIA-RELATED PSYCHOSIS
Quetiapine
Interactions: CNS depressants, phenytoin, thioridazine Contraindications: DEMENTIA-RELATED PSYCHOSIS
Lorazepam CIV
Interactions: CNS depressants, probenecid, valproate Contraindicated: benzodiazepine hypersensitivity, narrow-angle glaucoma
Rosuvastatin
Interactions: CYCLOSPORINE, warfarin, gemfibrozil, ANTACIDS Contraindications: active liver disease, pregnancy/lactation PREGNANCY CATEGORY X
Buprenorphine w/ Naloxone CIII
Interactions: CYP 3A4 inhibitors/inducers, BZDP Contraindications: COPD, cor pulmonale, hypoxia, resp. depression
Nebivolol
Interactions: CYP2D6 (paroxetine, fluoxetine, propafenone, quinidine), digoxin, CCB Contraindications: Bradycardia, heart block > 1st degree, cardiogenic shock, decompensated CHF, sick sinus syndrome, severe hepatic impairment
Tiotropium
Interactions: CYP2D6/3A4 inhibitors Contraindications: Atropine sensitivity
Tolterodine
Interactions: CYP3A4 (azoles, erythromycin, clarithromycin, cyclosporine, vinblastine) Contraindications: Urinary retention, gastric retention, uncontrolled narrow-angle glaucoma, hypersensitivity
Simvastatin
Interactions: CYP3A4 Inhibitors, grapefruit Contraindications: Hypersensitivity, pregnancy/lactation, liver disease, strong CYP3A4 agents, excessive alcohol PREGNANCY CATEGORY X
Solifenacin
Interactions: CYP3A4 inh (azole, ritonavir, clarithromycin) Contraindications: Urinary retention, gastric retention, uncontrolled narrow-angle glaucoma; Caution - bladder outflow obstruction, QT prolongation
Alendronte
Interactions: Calcium, antacids, aspirin, NOTHING W/IN 30 MIN OF DOSE Contraindications: Esophageal abnormalities, cannot sit/stand upright for 30 min, hypocalcemia
Spironolactone
Interactions: Captopril, K+ sparing medications, K+ supplements, DIGITALIS Contraindications: Anuria, acute renal insufficiency, renal impairment, hyperkalemia, sulfonamide/spironolactone sensitivity
Lithium
Interactions: Carbamazepine, iodides, NSAIDS, ACEI, thiazides, urinary alkalinizers, HALOPERIDOL Contraindications: Renal/cardiovascular disease, severe debilitation, dehydration, Na depletion; Caution - diuretics, ACEI
Ziprasidone
Interactions: Carbamazepine, ketoconazole, dofetilide, sotalol, quinidine, Class Ia and III antiarrhythmics, -floxacin Contraindications: DEMENTIA-RELATED PSYCHOSIS, QT prolongation, recent MI, uncompensated HR, drugs prolonging QT interval; Caution - hypokalemia, hypomagnesemia, bradycardia
Oxcarbazepine
Interactions: Carbamazepine, phenobarbital, phenytoin, VPA, verapamil, estrogens/progestins Contraindications: Hypersensitivity to either carbamzepine or oxcarbazepine, stevens-johnson, toxic epidermal necrolysis, hyponatremia
Memantine
Interactions: Carbonic anhydrase inhibitors, sodium bicarb Contraindications: Hypersensitivity
Glipizide
Interactions: Chloramphenicol, alcohol, MAOIs, phenylbutazones, salicylates, sulfonamides, thiazide diuretics Contraindications: Juvenile, unstable or complicated diabetes mellitus, allergy to sulfa drugs, diabetic ketoacidosis w or w/o coma
Losartan w/ HCTZ
Interactions: Cimetidine, phenobarbital, DIGITALIS, diazoxide, NSAIDS, alcohol, barbituates, narcotics, cholestyramine Contraindications: Volume-depleted, pregnant, anuria, sulfonamide sensitivity, pregnancy
Pramipexole
Interactions: Cimetidine, ranitidine, CCB, quinidine/quinine Contraindications: Orthostatic hypotension, renal dysfunction
Cyanocobalamin
Interactions: Colchine, alcohol, antibiotics Contraindications: Early Lebers disease
Insulin Aspart, rDNA origin
Interactions: Corticosteroids, diltiazem, dobutamine, epinephrine, contraceptives, thiazides, thyroid, tobacco, alcohol, b-blockers, MAOIs Contraindications: Hypoglycemia
Sulfamethoxazole w/ Trimethoprim
Interactions: Cyclosporine, anticoagulants Contraindictions: Infants < 2 months, pregnancy/nursing, sulfa allergies, megaloblastic anemia
Diltiazem
Interactions: Cyclosporine, cimetidine, carbamazepine Contraindications: Sick sinus syndrome, second/third-degree AV block
Digoxin
Interactions: DIURETICS, AMIODARONE, QUINIDINE, PROPAFENONE, ERYTHROMYCIN, CYCLOSPORINE, TETRACYCLINES, VERAPAMIL Contraindications: V. fibb
Testosterone, CIII
Interactions: Decreased insulin requirements, anticoagulants, corticosteroids Contraindications: Males with carcinoma of breast/prostate, BPH, prostate cancer; Caution - CHF, hyperlipidemia PREGNANCY CATEGORY X
Esomeprazole
Interactions: Diazepam, ketoconazole, digoxin, cyanocobalamin, ampicillin, iron salts
Sotalol
Interactions: Disopyramide, quinidine, procainamide, amiodarone, CCB, reserpine, antacids Contraindications: Bronchial asthma, sinus bradycardia, second/third degree AV block, long QT syndromes, cardiogenic shock, uncontrolled CHF
Hydrochlorothiazide
Interactions: Electrolyte disturbances (digitalis) Contraindications: Anuria, sulfonamide hypersensitivity
Codeine w/ Guaifenesin, CIV
Interactions: Elevate VMA test, alcohol, CNS depressants Contraindications: Persistent cough; Caution - increased ICP, head injury, Addison's disease, hypothyroidism
Nitroglycerin
Interactions: Ergot, heparin, SILDENAFIL Contraindications: Intolerant to organic nitrates, anemia, closed-angle glaucome, postural hypotension, intracranial pressure, early MI, hypotension, hypovolemia, pericardial tamponade
Sumatriptan
Interactions: Ergot-containing drugs, MAOI Contraindications: Do not give IV, IHD, Prinzmetal's angina, uncontrolled hypertension, migraines
Cefuroxime
Interactions: Estrogen oral contraceptives, probenecid, urine glucose tests (false +) Contraindications: Penicillin/cephalosporin allergy; Caution - renal impairment
Metformin
Interactions: Furosemide, Cimetidine, Nifedipine, Alcohol Contraindications: Impaired renal function (male>1.5, female>1.4)
Lovastatin
Interactions: GEMFIBROZIL, grapefruit juice Contraindications: Pregnancy/lactation, active liver disease, elevated serum transaminases PREGNANCY CATEGORY X
Pravastatin
Interactions: Gemfibrozil, erythromycin, immunosuppressive agents Contraindications: Pregnancy/lactation, acute liver disease PREGNANCY CATEGORY X
Ezetimibe
Interactions: Gemfibrozil, fenofibrate, cholestyramine Contraindications: Hepatic insufficiency
Atorvastatin
Interactions: Grapefruit Contraindications: Pregnancy/lactation, liver disease, excessive alcohol PREGNANCY CATEGORY X
Carbidopa w/ Levodopa
Interactions: Hydantoins, pyridoxine, MAOI Contraindications: Narrow-angle glaucoma, skin lesion/melanoma, MAOI use or w/in 14 days; Caution - psychosis, cardiovascular/pulmonary disease, peptic ulcer, bronchial asthma
Lisinopril
Interactions: K supplements Contraindications: History of angioedema from ACE inhibitor treatment
Potassium Chloride
Interactions: K-sparing diuretics, K-containing medications/salt substitutes Contraindications: Hyperkalemia
Dexlansoprazole
Interactions: Ketoconazole, ampicillin, iron salts, digoxin, tacrolimus Contraindications: Hypersensitivity, long-term use (osteoporosis)
Guanfacine
Interactions: Ketoconazole, rifampin, antihypertensives, CNS depressants, VPA Caution: Severe coronary insufficiency, recent MI, CVD, renal/hepatic failure
Risperidone
Interactions: Levodopa, carbamazepine, fluoxetine, clozapine Contraindications: DEMENTIA-RELATED PSYCHOSIS, neuroleptic malignant syndrome
Insulin Lispro, rDNA origin
Interactions: Lots Contraindications: Hypoglycemia
Albuterol
Interactions: MAO inhibitors Contraindications: Hypersensitivity
Citalopram
Interactions: MAO inhibitors Contraindications: May increase suicidal thoughts in children, teenagers, w/in 14 days of MAO inhibitors
Sertraline
Interactions: MAO inhibitors, pimozide Contraindications: May increase suicidal thoughts in children, teenagers, w/in 14 days of MAO inhibitors, tasks requiring alertness
Methadone CII
Interactions: MAOI, rifampin, pentazocine, CNS depressants Contraindications: Injection use, acute asthma attack, COPD, resp. depression
Escitalopram
Interactions: MAOIs, CYP3A4 inhibitors, cimetidine, aspirin, NSAIDs Contraindications: 14 days of MAOIs
Bupropion
Interactions: MAOIs, L-dopa, alcohol, tricyclic antidepressants, paroxetine, fluoxetine, sertraline, haloperidol, risperidone, thioridazine, metoprolol (CYP2D6) Contraindications: Seizure disorder, history of bulimia or anorexia nervosa, 14 days of MAOIs
Amphet w/ Dextroamphet CII
Interactions: MAOIs, furazolidone, sodium bicarbonate, antihypertensives Contraindications: Advanced arteriosclerosis, cardiovascular disease, moderate hypertension, hyperthyroidism, agitated states, glaucoma, 14 days of MAOIs
Buspirone
Interactions: MAOIs, grapefruit juice
Paroxetine
Interactions: MAOIs, phenytoin, phenobarbital, cimetidine, WARFARIN, procyclidine, aspirin, NSAIDs Contraindications: Pregnancy, 14 days of MAOIs
Methylphenidate CII
Interactions: MAOIs, phenytoin, phenobarbital, warfarin, SSRIs, clonidine Contraindications: Anxiety, tension, agitation, glaucoma, motor tics, family history of Tourette's syndrome, 14 days of MAOIs
Nitrofurantoin
Interactions: Magnesium Contraindications: Anuria, oliguria, impaired renal function, infants < 1 mo; Caution - G6P deficiency, peripheral neuropathy, pulmonary disease
Oseltamivir
Interactions: NONE Contraindications: Not a substitute for influenza vaccine
Valsartan
Interactions: NSAIDS Contraindications: Pregnancy
Clopidogrel
Interactions: NSAIDS, CYP2C9 metabolites, OMEPRAZOLE, esomeprazole Contraindications: Bleeding
Methotrexate
Interactions: NSAIDS, phenytoin, sulfonamides, mercaptopurine, ABX, penicillin, theophylline Contraindications: Only indicated for life-threatening neoplastic disease, patients with psoriasis or RA, severe recalcitrant, disabling disease not responsive to other forms of therapy; alcoholism, liver disease, immunodeficiency syndrome, pre-existing blood dyscrasias PREGNANCY CATEGORY X
Mupirocin
Interactions: Nasal ointments Contraindications: Not for opthalamic use
Clindamycin
Interactions: Neuromuscular blocking agents, clindamycin, erythromycin Contraindications: Severe/persistent diarrhea
Losartan
Interactions: No major interactions
Pantoprazole
Interactions: No major interactions Contraindications: Hypersensitivity to components
Ondansetron
Interactions: None
Hydroxychloroquine
Interactions: None Contraindications: Hypersensitivity, visual disturbances (4-aminoquinolines), long-term use in children
Olmesartan
Interactions: None Contraindications: Hypersensitivity, volume depleted
Nystatin
Interactions: None Contraindications: Systemic mycoses
Glimepiride
Interactions: None; CYP450 2C9 Contraindications: Diabetic ketoacidosis w/ or w/o coma, aware of hypoglycemia
Naproxen
Interactions: Oral anticoag, lithium, methotrexate, NSAIDS Contraindications: NSAID sensitivity
Carbamazepine
Interactions: Oral anticoag, valproic acid, cimetidine, diltiazem, fluoxetine, verapamil, MACROLIDES, hydantoins, doxycycline, haloperidol, grapefruit juice Contraindications: Bone marrow depression, MAO w/in 14 days
Levothyroxine
Interactions: Oral anticoagulants Contraindications: Uncorrected adrenal cortical insufficiency, uncorrected thyrotoxicosis, acute MI
Mometasone Furoate
Interactions: Oral corticosteroids Contraindications: Caution - pregnancy/lactation, TB, fungal/bacterial/systemic/viral infections
Montelukast
Interactions: Phenobarbital
Oxycodone CII
Interactions: Phenothiazines, anesthetics, hypnotics, sedatives, alcohol, muscle relaxants Contraindications: Respiratory depression, bronchial asthma, paralytic ileus
Morphine CII
Interactions: Phenothiazines, anesthetics, sedatives, hypnotics, alchol, muscle relaxants, analgesics Contraindications: Respiratory depression, acute/sevre bronchial asthma, paralytic ileus
Donepezil
Interactions: Phenytoin, carbamazepine, phenobarbital, rifampin, dexamethasone, ketoconazole, quinidine Contraindications: Donepezil/piperidine derivative hypersensitivity
Lamotrigene
Interactions: Phenytoin, carbamazepine, phenobarbital, rifampin, valproic acid, ORAL CONTRACEPTIVES
Acyclovir
Interactions: Probenecid Contraindications: Hypersensitivity, renal impairment, dehydration
Valacyclovir
Interactions: Probenecid Contraindications: Renal impairment, dehydration
Rivaroxaban
Interactions: RIFAMPIN, PHENYTOIN, ST JOHNS WART, CARBAMAZEPINE, KETOCONAZOLE, RITONAVIR, CLARITHROMYCIN, enoxaparin, warfarin, aspirin, clopidogrel, NSAIDS Contraindications: Active pathological bleedings, hypersensitivity
Carvedilol
Interactions: Rifampin, cimetidine, CYP2C9 inhibitors Contraindications: Cardiac failure, asthma, AV block, sick sinus syndrome, cardiogenic shock, bradycardia Caution: Hepatic dysfunction, diabetics
Amlodipine
Interactions: Simvastatin
Ropinirole
Interactions: Smoking, omeprazole, ciprofloxacin, estrogens, dopamine antagonists Contraindications: Syncope, postural hypotension
Valsartan w/ HCTZ
Interactions: Sulfonylureas, DIGITALIS-induced arrhythmia from electrolyte disturbances, diazoxide, lithium, NSAIDS Contraindications: Anuria, pregnancy, salt-depleted/volume depleted PREGNANCY CATEGORY D (2/3 trimester)
Ipratropium w/ Albuterol
Interactions: Sympathomimetics, tricyclic antidepressants, MAOIs, non-potassium sparing diuretics Contraindications: Combivent-soybean or peanut sensitivity
Fluticasone Propionate
Interactions: Systemic Corticosteroids Cautions: Pregnant/lactating women, multiple infections
Triamcinolone
Interactions: Systemic corticosteroids Contraindications: Sensitivity
Budesonide & Formoterol
Interactions: Systemic corticosteroids, sympathomimetics, TCAs, MAOIs, B-blockers, CYP3A4 inhibitors Contraindications: Primary treatment of staticus asthmaticus, B2-AGONIST INCREASES RISK OF ASTHMA-RElATED DEATH
Propranolol
Interactions: Theophyllines, clonidine, rifampin, NSAIDS, VERAPAMIL, epinephrine, prazosin Contraindications: Cardiogenic shock, bronchial asthma, sinus bradycardia, >1st degree heart block, CHF
Metoprolol Tartrate
Interactions: Verapamil Contraindications: Sinus bradycardia, heart block>1st degree, cardiogenic shock, CHF, cardiac failure, HR<45 bpm, SBP<100 mmHg Cautions: Diabetes
Metoprolol Succinate
Interactions: Verapamil Contraindications: Sinus bradycardia, heart block>1st degree, cardiogenic shock, HF, sick sinus syndrome Cautions: Diabetes
Fenofibrate
Interactions: WARFARIN, HMG-CoA reductase inhibitors, cholestyramine Contraindications: Hepatic or renal dysfunction, primary biliary cirrhosis, preexisting gallbladder disease
Fluconazole
Interactions: Warfarin, phenytoin, midazolam, VORICONAZOLE, cyclosporine, antidiabetic meds, rifampin
Pioglitazone
Interactions: oral contraceptives, azoles, gemfibrozil, rifampin Contraindications: Class III/IV CHF, Type 1 DM, resumption of ovulation; Caution - hepatic dysfunction