Adipose tissue

adipoctyes are

- large cells - shapes include round oval or polyhedral

white adipose tissue

- predominate type in adults

internally fat is found

-around organs - in omentum - in mesenteries -bone marrow - feet axilla -orbits Fat A*s Mom say MOOO

brown adipocytes generate

heat

adipocytes differentiate from

unidifferentriated mesenchymal cells

what type of fat tissue forms a layer in the connective tissue under the skin called the hypodermis

white adipose

what type of adipose tissue is called unilocular

white adipose tissue - only one fat droplet

nucleus and cytoplasm in adipocytes are displaced by what?

large lipid droplets

hibernoma usually contain

a mix of white and brown fat - pure hibernomas are very rare

liposarcoma

a rare, malignant tumor of adipose tissue - tumor containing cell that are less differentiated are more aggressive and tend to metastasize

adipose tissue is composed of

adipocytes ( fat storing cells)

tissues that are primary composed of adipocytes are called

adipose tissue

thermogenic activity is regulated bu

an uncoupling protien found in mitochondria, UCP or thermogenin

brown adipose tissue in adults is localized to

areas around the kidney, adrenal glands, aorta, regions of the neck and mediastium

the movement of protons from the inner compartment of the mitochondria

dissipates the mitochondrial proton gradient, uncoupling respiration from ATP synthesis - and the energy produced by the mitochondria is used as heat

brown adipocytes

have a central nucleus, multiple fat droplets and abundant mitochondria

what is the characteristic appearance of adipose tissue

honeycomb

where are hibernoma usually found

in the periscapular region

adipocytes can be found as

individual cells and small groups of cells scattered throughout loose connective tissue

brown adipose tissue is divided

into lobes by connective tissue

adipose tissue

is a specialized highly vascular tissue

brown adipose tissue ( when in life is it present)

is present during fetal life and diminishes during the first decade after birth - also called multiocular = contains numerous fat droplets

lipoma

is the most common benign adipose tissue tumor

non-shivering thermogenesis

is the process by which hibernating animals produce heat ultizing brown fat cell

what happens when brown fat is oxidized

it produces heat, which warm the blood flowing through the tissue

UCP-1 or Thermogenin works by

it uncouples oxidation of fatty acids from the production of ATP

adipocytes in brown adipose tissue contain

lots of mitochondria

distribution of brown adipose tissue in newborns

multiocular adi[ose tissue constitutes 2- 5 % of the body weight and is as shown in the photo - the black areas indicate multiocular adipose tissue and shaded areas are a mixture of multiocular and uniolcular adipose tissue

non-shivering thermogenesis also occurs in

newborn humans to prevent extensive heat loss

the lipid droplet in adipoctytes are

not membrane bound

what transcription factor plays a roles in the differentiation of adipocytes and the initiation of lipid metabolism

peroxisome proliferation activated receptor gamma ( PPAR gamma)

hibernoma

rare, benign, slow growing tumors of BROWN FAT

the thickness of the hypodermis depends on what

the different parts of the body - depends on the sex of the individual

UCP-1 facilitates

the movement of protons across the inner mitochondrial membrane - that leads to the production of heat instead of ATP

there are two types of adipose tissue

white and brown