Adipose tissue
adipoctyes are
- large cells - shapes include round oval or polyhedral
white adipose tissue
- predominate type in adults
internally fat is found
-around organs - in omentum - in mesenteries -bone marrow - feet axilla -orbits Fat A*s Mom say MOOO
brown adipocytes generate
heat
adipocytes differentiate from
unidifferentriated mesenchymal cells
what type of fat tissue forms a layer in the connective tissue under the skin called the hypodermis
white adipose
what type of adipose tissue is called unilocular
white adipose tissue - only one fat droplet
nucleus and cytoplasm in adipocytes are displaced by what?
large lipid droplets
hibernoma usually contain
a mix of white and brown fat - pure hibernomas are very rare
liposarcoma
a rare, malignant tumor of adipose tissue - tumor containing cell that are less differentiated are more aggressive and tend to metastasize
adipose tissue is composed of
adipocytes ( fat storing cells)
tissues that are primary composed of adipocytes are called
adipose tissue
thermogenic activity is regulated bu
an uncoupling protien found in mitochondria, UCP or thermogenin
brown adipose tissue in adults is localized to
areas around the kidney, adrenal glands, aorta, regions of the neck and mediastium
the movement of protons from the inner compartment of the mitochondria
dissipates the mitochondrial proton gradient, uncoupling respiration from ATP synthesis - and the energy produced by the mitochondria is used as heat
brown adipocytes
have a central nucleus, multiple fat droplets and abundant mitochondria
what is the characteristic appearance of adipose tissue
honeycomb
where are hibernoma usually found
in the periscapular region
adipocytes can be found as
individual cells and small groups of cells scattered throughout loose connective tissue
brown adipose tissue is divided
into lobes by connective tissue
adipose tissue
is a specialized highly vascular tissue
brown adipose tissue ( when in life is it present)
is present during fetal life and diminishes during the first decade after birth - also called multiocular = contains numerous fat droplets
lipoma
is the most common benign adipose tissue tumor
non-shivering thermogenesis
is the process by which hibernating animals produce heat ultizing brown fat cell
what happens when brown fat is oxidized
it produces heat, which warm the blood flowing through the tissue
UCP-1 or Thermogenin works by
it uncouples oxidation of fatty acids from the production of ATP
adipocytes in brown adipose tissue contain
lots of mitochondria
distribution of brown adipose tissue in newborns
multiocular adi[ose tissue constitutes 2- 5 % of the body weight and is as shown in the photo - the black areas indicate multiocular adipose tissue and shaded areas are a mixture of multiocular and uniolcular adipose tissue
non-shivering thermogenesis also occurs in
newborn humans to prevent extensive heat loss
the lipid droplet in adipoctytes are
not membrane bound
what transcription factor plays a roles in the differentiation of adipocytes and the initiation of lipid metabolism
peroxisome proliferation activated receptor gamma ( PPAR gamma)
hibernoma
rare, benign, slow growing tumors of BROWN FAT
the thickness of the hypodermis depends on what
the different parts of the body - depends on the sex of the individual
UCP-1 facilitates
the movement of protons across the inner mitochondrial membrane - that leads to the production of heat instead of ATP
there are two types of adipose tissue
white and brown