BB Media Lab Quizes
All of the following are appropriate indications for the use of FFP , EXCEPT: a. volume expansion b. severe bleeding in the presence of significantly elevated PT secondary to vitamin K deficiency c. replacement component after plasma exchange in patients with TTP or HUS d. dilutional coagulopathy with significant active bleeding, and PT and PTT twice normal
a
When is weak D testing optional (not required) a. testing for weak D on potential transfusion recipient samples b. testing on donor RBCs c. testing cord blood on infants born to Rh-neg mom d. testing for Rh immune globulin workups
a
which is the incorrect statement about sample labeling requirements a. relabeled tubes should be used b. the label should have the patients first and last name c. the label should have a unique ID # d. the date of collection should be included
a
Which of the following antibodies causes the MOST severe cases of HDFN?
anti-D
which antibody is present in the blood of an individual with the bombay phenotype that will cause agglutination with any non-bombay individuals blood
anti-H
The serum from a patient of african american descent is reactive with all screening and panel cells. which antibody directed to a high incidence antigen is most likely present
anti-U
How are antibodies to the ABO blood group antigens unique ?
antibodies are naturally occurring to antigens that are absent from the RBC membrane
What is the correct description for group 2 discrepancies ?
between forward and reverse from weak/missing antigens
what does the hh genotype give rise to ?
bombay phenotype
A former patient had anti-E four years ago, but her antibody panel is now neg. since she now needs blood for surgery, what should the BB do?
crossmatch E-neg units
in order to avoid repeating pretransfusion testing on a neonate during 1 hospital admission, all of the following must be true, EXCEPT: a. received only ABO- compatible blood b. received only Rh- compatible blood c. no unexpected antibodies in serum or plasma d. has only received formula for nourishment
d
At what frequency must the temp of a chart recorder be compared to a thermometer?
daily
what is the fundamental purpose of the full, pretransfusion crossmatch?
detect antibodies in recipient serum/plasma that react with donor RBCS
At what frequency should quality control testing be performed on each lot of AHG to be in compliance with the FDA's current good manufacturing practices requirements ?
each day of use
IgG coated red cells are added to negative antiglobulin tests to detect which of the following sources of error:
failure to add AHG
what blood group are the RBC screening cells for antibody screens
group O
In an extreme emergency , if the ABO and Rh type are unknown which of the following should be given to the patient?
group O, Rh neg blood
Which of the following statements best describes Rh antibodies?
immune IgG
Which of the following patients are at risk for TA-GVHD and require irradiated cellular blood products ?
immunocompromised pt including neonates less than 4 months of ag & chemo pt
which of the following error could most likely occur in the preanalytical phase
incorrectly collected sample
According to CLIA'88 which of the following lab personal is responsible for ensuring the employment of qualified, competent testing personnel within a moderate to high complexity testing environment
lab director
Which of the following is generally considered equivalent to CMV seronegative RBCs for use in an exchange transfusion to a newborn?
leukoreduced RBCs
What term refers to the process that must be followed when notification is received that a donor of a unit transfused now tests positive for an infectious disease?
look back
_______ process involves the donation facility looking back at previous donations to ID recipients who received a blood product from a donor that is newly tested pos for an infectious disease (time frame vary by disease) * the goal is to ID recipients who are at risk of receiving this infected blood product
look back
What is the first line of TX for moderate to severe hemophilia A ?
lyophilized factor VIII component
(Major/Minor) crossmatch involves testing donor red blood cells & recipient serum for compatibility
major
Most antibodies present in cord blood are of _____ origin
maternal
(Major/Minor) crossmatch involves testing donor serum and recipient red blood cells for compatibility
minor
In theory, how difficult is it to find compatible blood unit and to ID the antibody in a patient with an antibody to a low frequency antigen?
not difficult to find compatible blood but difficult to ID
Why is weak D testing not performed on pregnant women?
not required as part of prenatal eval (bc not possible to differentiate weak D from partial D serotype)
How often are proof of competency evaluation supposed to occur AFTER the first year of employment according to CLIA?
once every year
when is a computer crossmatch acceptable?
patient has no HX or clinically significant Ab detected and the ABSC on current sample is neg
which of the following blood components would be MOST appropriate for a 9 y/o girl who is suspected of having idiopathic thrombocytopenic purpura (ITP), including a low platelet count & bleeding gums ?
platelets
which of the following would ensure positive patient ID prior to specimen collection ?
pt full name and hospital or medical record number
The rosette test is a __________ test to determine if a __________ has occurred
qualitative; fetal maternal hemorrhage
the KB test or fetal hemoglobin test is considered (qualitative/ quantitative)
quantitative
What characteristic best describes IgG antibodies produced against RBCs
react best at 37
what characteristic is usually associated with IgM antibodies directed against red cells?
react best at RT
In the Coombs phase of a crossmatch, what is the proper procedure to follow if the Check Cells give a negative reaction?
repeat procedure with new AHG reagent and check cell washer
How often is competency required in the first year of employed for a NEW staff member who is performed non-waived testing according to CLIA'88
semiannually
when administering FFP, which one of the following is considered standard blood bank practice ?
should be ABO compatible with the recipients RBCs
A bombay individual's blood specimen can be differentiated from a blood specimen of a group O person by which of the following ?
testing with anti-H lectin (ulex europeus)
which of the following is true of the classic bombay phenotype ?
two h genes are inherited at the H locus
Which of the following can be used to confirm if someone has the Bombay phenotype ?
ulex europaeus
A D-neg mother gives birth to a baby that tests as D-neg in the IS phase, what step should be performed ?
weak D test
Packed RBCs and whole blood are shipped on :
wet ice
A negative rosette determines; the fetal-maternal hemorrhage was probably not greater than 30ml (packed RBC/ whole blood) and 1 vial of RhIG will be sufficient
whole blood
The plant lectin obtained from the Dolichos biflorus plant will agglutinate which of the following?
A1 cells
Lectin Dolichos biflorus agglutinated which type of cells
A1B
What is/are considered an accrediting agency for quality and safety in the blood industry?
AABB
Which of the following fresh frozen plasma ABO types would be suitable for a transfusion to an AB neg patient?
AB neg and AB pos only
Units of A neg, B neg and O neg RBCs are shipped to your transfusion service. What testing MUST be performed by your facility prior to placing these units into your inventory?
ABO & Rh
Lectin from the seeds of Dolichos biflorus is a source of which of the following ?
Anti-A1
The BB is monitored by the _____ since blood products are considered similar to a "drug" given to a patients due to its therapeutic properties
FDA
Which blood product should be shipped on dry ice ?
FFP & cryo
Whole blood or RBC units will be shipped from the american red cross to the transfusion facility at what temp ?
1-10 C
A refrigerator used to store whole blood must be able to maintain a temp in the ranges of:
1-6 C
Red cells are noted at"
1-6 C
Platelets should be stored at what temp?
20-24 C
what is the proper temp for thawed cryo?
20-24 C
what is the max interval during which a recipient sample may be used for compatibility testing if the patient has recently been transfused or was pregnant within the past 3 months
3 days
donor and recipient blood samples must be kept for at least how long after transfusion
7 days
RhIG must be administered within ____ hours to prevent the formation of _____
72; anti-D
The A1 subgroup represents approx what % of group A individuals
75-80
Fresh frozen plasma and cryoprecipitate are stored at :
< -18C
Bandeiraea simplicifolia has specificity to the ____ antigen
B
What section of the clinical lab is regulated by the FDA?
BB
Which of the following choices best describes the primary function of antibodies?
Binds with antigen
when a group O patients serum is not compatible with donor O RBCs and the auto control is negative, what is the most likely cause?
Bombay phenotype
Which of the following D variants has the best likelihood to receive D pos RBCs without any adverse effects?
C in trans to RHD
All of the following are included in a quality control program, EXCEPT :a. protocol to ID problems in equipment b. protocol to correct problems in equipment c. protocol to monitor problems in equipment d. protocol to prove patient results are correct
D
A D-pos mother with a D-neg fetus eliminates the possibility of HDFN due to the:
D antigen
Essential compounds of compatibility testing include all of the following EXCEPT:
DAT (so it includes: ABSC on recipient serum, major/computer crossmatch, ABO and Rh typing of recipient)
What action should be taken if a large clot is noticed in a red blood cell unit while the product is being prepared for release to the patient ?
DO NOT issue product
What is a characteristic of a person who is weak D?
Demonstrates a reduced # of D antigen sites on the surface of red cell
Which of the following is the most common reagent source for anti-A1
Dolichos biflorus seed extracts
the major crossmatch is performed using:
Donor's red cells and recipient's serum or plasma
The immunoglobulin class responsible for the etiology of HDFN is:
IgG
Which class of antibody can agglutinate RBCs after AHG is added to the test tube?
IgG
ABO antibodies are classified as which of the two immunoglobulin classes?
IgG and IgM
The most significant blood group antibodies belong to which immunoglobulin classes?
IgG and IgM
Which kind of immunoglobulins are predominantly found in Rh immune globulin ?
IgG anti-D
The majority of lewis antibodies are of which immunoglobulin class?
IgM
which of the following is the predominant immunoglobulin class for anti-A and anti-B antibodies in group A and B individuals ?
IgM
IF a rosette test is positive; what test must be performed ?
KB
Iberis amara has specificity to the ____ antigen
M
Which of the following packed RBC ABO type would be appropriate for transfusion to an O neg patient of child bearing age
O neg only
platelets ar shipped at"
RT
A patient with Multiple Myeloma has the following ABO typing discrepancies due to :
Rouleaux
HLA antibodies are responsible for which of the following transfusion reactions?
TRALI
