Biology 122 - Semester 2 - Week 1 Quiz

Pharmacokinetics refers to Select one: a. Absorption, distribution, metabolism and excretion of drugs b. Exploring the herbal sources of various drugs c. How a drug alters the functioning of the body d. The changes in cell membranes that occur as a result of the binding of a drug to a specific receptor e. Toxic effect of drugs only

a. Absorption, distribution, metabolism and excretion of drugs

A drug that binds to a cell receptor and affects a response is called Select one: a. An agonist b. A receptor blocker c. A channel blocker d. An antagonist

a. An agonist

Adrenaline binds to adrenergic receptors and causes an increase in heart rate. An adrenergic agonist will Select one: a. Bind to adrenergic receptors and cause an increase in heart rate b. Bind to adrenergic receptors and cause no change in heart rate c. Bind to adrenergic receptors and cause a decrease in heart rate d. Bind to adrenergic receptors and block them e. Bind to adrenergic receptors and destroy them

a. Bind to adrenergic receptors and cause an increase in heart rate

Bleeding associated with co-administration of aspirin with warfarin is an example of Select one: a. Pharmacodynamic drug interaction b. Pharmacokinetic drug interaction c. Antagonism d. Type I hypersensitivity e. All of the above

a. Pharmacodynamic drug interaction

Most drugs and metabolites are excreted by Select one: a. The kidneys b. The lungs c. Saliva d. Bile

a. The kidneys

Drugs act on carrier molecules by Select one: a. blocking the carrier molecules b. competitively inhibiting the carrier molecule c. destroying the carrier molecule d. acting as agonists e. acting as antagonists

a. blocking the carrier molecules

How many phases of hepatic metabolism are there? Select one: a. 1 b. 2 c. 4 d. 10

b. 2

A pro-drug is Select one: a. A drug given in its active form b. A drug given in its inactive form, requiring metabolism c. A drug given to promote growth d. A drug given to prevent metabolism of another drug

b. A drug given in its inactive form, requiring metabolism

Which of the following is a plasma protein? Select one: a. Protamine b. Albumin c. Prostacyclin d. Meatamine

b. Albumin

An antagonist can be Select one: a. Competitive and comparative b. Competitive and non-competitive c. Competitive and complimentary

b. Competitive and non-competitive

A pharmacodynamic factor that modifies responses to drugs includes Select one: a. Body water composition b. Receptor number c. Age d. Liver and kidney disease e. Heart disease

b. Receptor number

Pharmacodynamics is defined as Select one: a. The effect our body has on drugs b. The effect a drug has on our bodies c. The movement of a drug around the body d. The action of the liver on drug molecules

b. The effect a drug has on our bodies

Drug X decreases the metabolism of drug Y. Which of the following are true? Select one: a. This is a pharmacodynamic drug interaction. b. This is a pharmacokinetic drug interaction. c. The bioavailability of drug Y would decrease. d. The bioavailability of drug X would increase. e. None of the above.

b. This is a pharmacokinetic drug interaction.

Which of the following is true for Type A adverse drug reactions (ADRs) Select one: a. Type A ADRs are bizarre and unpredictable b. Type A ADRs are an exaggeration of the drug effects c. Drug allergies belong to this category d. Type A ADRs produce a delayed response e. Type A ADRs relate to withdrawal from a drug

b. Type A ADRs are an exaggeration of the drug effects

Infants and children may experience systemic effects from topically administered drugs because of their Select one: a. higher heart rate b. increased surface area to mass ratio c. greater blood flow to skin d. thicker subcutaneous fat layer e. higher body temperature

b. increased surface area to mass ratio

The four processes in pharmacokinetics are Select one: a. Receptors, ion channels, transport systems and enzymes b. Administration, absorption, metabolism and elimination c. Absorption, distribution, metabolism and excretion d. Stomach, liver, kidney and lungs

c. Absorption, distribution, metabolism and excretion

What route should drugs subject to first pass metabolism not be given by? Select one: a. Sublingual b. IM c. Oral d. IV

c. Oral

The main method of renal elimination of a drug is by Select one: a. Active glomerular filtration b. Selective reabsorption c. Passive distal excretion d. Active secretion into the collecting duct

c. Passive distal excretion

The half-life time of drugs administered to elderly people typically Select one: a. decreases due to a decreased ability to metabolise drugs. b. decreases due to an increased ability to metabolise drugs. c. increases due to a decreased ability to metabolise drugs. d. increases due to an increased ability to metabolise drugs. e. this cannot be determined from the information provided.

c. increases due to a decreased ability to metabolise drugs.

The development of bacterial resistance Select one: a. always results in resistance to all antibiotics b. can only be achieved through plasmid transfer c. is often facilitated by Health Care Professionals d. occurs as a result of the antibiotic, not the bacteria e. occurs as a result of incorrect manufacturing practices

c. is often facilitated by Health Care Professionals

Which of the following variables are decreased in neonates in comparison to adults? Select one: a. Drug metabolism b. Drug excretion c. Drug absorption d. A and B are correct e. A B and C are correct

d. A and B are correct Drug metabolism and Drug excretion

In which of the following is the liver most significant? Select one: a. distribution of blood‐borne drugs b. absorption of orally administered drugs c. excretion of water‐soluble drugs d. bioavailability after oral administration e. excretion following parenteral administration

d. bioavailability after oral administration

Drugs can act on which of the following proteins? Select one: a. Receptors. b. Enzymes. c. Ion channels. d. Carrier molecules. e. All of the above.

e. All of the above.

Drug A and B are the same drug and are given at the same time and dose, except that drug A is administered orally, and drug B is administered sublingually. Which of the following statements about drug A and B is correct? Select one: a. The bioavailability of drug A will be higher than the bioavailability of drug B b. The hepatic first-pass only affects drug B and not drug A c. The absorption rate of drug A will be faster than drug B d. The excretion rate of drug A will be faster than drug B e. Drug B will bypass the liver and be absorbed directly into the blood plasma

e. Drug B will bypass the liver and be absorbed directly into the blood plasma

Which of the following does NOT have an effect on drug absorption? Select one: a. Size of drug molecule b. Drug dissolution rate c. Lipid solubility of drug d. Surface area of absorbing membrane e. Drug bioavailability

e. Drug bioavailability