DNA Mutation and RepairA bulge in the DNA double strand width occurs when 2 _______________________ occur across from each other.
In each repair system, ____________________________ seals the gap after the correct nucleotide has been added.
DNA Ligase
The enzyme __________________________________ has 3' - 5' exonuclease activity.
DNA Polymerase III
________________________________ is a helicase used in nucleotide excision repair.
UvrD
If a mutation occurs in the DNA such that guanine is across from uracil, then the most likely repair system to recognize and correct this mutation would be _______________________________ .
base excision repair
A single base substitution in the coding region of a gene that exchanges one amino for a stop codon is called a ______________________ mutation.
nonsense
Xeroderma pigmentosum is caused because of a defect in the ____________________________________________ repair system.
nucleotide excision repair
A bulge in the DNA double strand width occurs when 2 _______________________ occur across from each other.
purines
In mismatch repair, ______________________________ recognizes and binds to the methylated adenine on the parental DNA strand.
MutH
A deletion of 4 nucleotides from the coding region of a gene would result in a _________________________ mutation.
frameshift
CAG encodes the amino acid ____________________________ and when the number of CAG repeats exceeds _____________ then neurological symptoms appear consistent with Huntington's disease.
glutamine, 35
Exposure to radiation and chemicals is responsible for causing _______________ mutations.
induced