DNA Mutation and RepairA bulge in the DNA double strand width occurs when 2 _______________________ occur across from each other.

In each repair system, ____________________________ seals the gap after the correct nucleotide has been added.

DNA Ligase

The enzyme __________________________________ has 3' - 5' exonuclease activity.

DNA Polymerase III

________________________________ is a helicase used in nucleotide excision repair.

UvrD

If a mutation occurs in the DNA such that guanine is across from uracil, then the most likely repair system to recognize and correct this mutation would be _______________________________ .

base excision repair

A single base substitution in the coding region of a gene that exchanges one amino for a stop codon is called a ______________________ mutation.

nonsense

Xeroderma pigmentosum is caused because of a defect in the ____________________________________________ repair system.

nucleotide excision repair

A bulge in the DNA double strand width occurs when 2 _______________________ occur across from each other.

purines

In mismatch repair, ______________________________ recognizes and binds to the methylated adenine on the parental DNA strand.

MutH

A deletion of 4 nucleotides from the coding region of a gene would result in a _________________________ mutation.

frameshift

CAG encodes the amino acid ____________________________ and when the number of CAG repeats exceeds _____________ then neurological symptoms appear consistent with Huntington's disease.

glutamine, 35

Exposure to radiation and chemicals is responsible for causing _______________ mutations.

induced