Exam 2 Hematology Ch. 8 - Lymphocytes - Quiz & Review Questions

The adult reference interval for peripheral blood lymphocytes is: A. 0.2-0.8 X 10^9/L B. 1.0-4.8 X 10^9/L C. 2.0-7.0 X 10^9/L D. 3.9-10.6 X 10^9/L

1.0-4.8 X 10^9/L

Which of the following describes the components used to construct an immunoglobulin? 5 heavy chains 2 identical heavy chains with 2 identical light chains 2 light chains 5 identical heavy chains with 2 identical light chains

2 identical heavy chains with 2 identical light chains

Lymphocyte concentrations in the peripheral blood are highest at what age level? A. 6 months B. 5 years C. 25 years D. 75 years

6 months

Which of the following describes the distribution of lymphocytes within the body? 80% are short-lived, 20% are long lived 75% exist in peripheral blood, 25% in lymph nodes and spleen 50% exist in the circulating pool, 50% in the marginating pool 95% are found in the lymph nodes and spleen, 5% in the peripheral blood

95% are found in the lymph nodes and spleen, 5% in the peripheral blood

Natural killer cells recognize and kill antigens with attached IgG. This mechanism is described as: Phagocytosis Innate immune response Cyanosis Antibody-dependent cellular activity

Antibody-dependent cellular activity

The function of the lymphocyte is: A. Phagocytosis B. Antigen recognition C. Hypersensitivity D. Allergic response

Antigen recognition

Which of the following is considered the "pan-B" antigen? CD8 CD10 CD19 CD4

CD19

Which of the following is found on early T-cell precursors? CD8 CD4 CD2 CD34

CD34

Which two CD markers are used to differentiate helper T cells and cytotoxic T cells? BCR and TCR CD4 and CD8 CD10 and CD19 CD1 and CD3

CD4 and CD8

The lymphoid progenitor that gives rise to T, B, and NK lymphocytes is recognized as which of the following? CFU_GM CLP CFU-T CMP

CLP

Which of the following is a characteristic of T lymphocytes? Cytokine secretion Phagocytosis of bacteria Few in number within peripheral blood Antibody synthesis

Cytokine secretion

What cell has CD8 on its surface? Cytotoxic T cell T-helper cell Macrophage B cell

Cytotoxic T cell

T, B, and NK lymphocytes can be differentiated by: Cytochemistry Flow cytometry Morphology Cytogenetic karyotype

Flow cytometry

Reactive lymphocytes differ from normal lymphocytes in that the reactive form: Has a condensed nuclear chromatin, eccentric nucleus, and deep blue cytoplasm Is larger with an increase in basophilic cytoplasm, vacuoles, and scalloped cell shape Has a condensed nuclear pattern with light pink cytoplasm Has many granules, deep basophilic cytoplasm, and blast-like nucleus

Has a condensed nuclear chromatin, eccentric nucleus, and deep blue cytoplasm

Which cell line matures and differentiates upon exposure to antigen? Monocytic Lymphocytic Neutrophilic Basophilic

Lymphocytic

Which cell line matures and differentiates upon exposure to antigen? Monocytic Neutrophilic Basophilic Lymphocytic

Lymphocytic

Which of the following terms describes an absolute increase in the number of lymphocytes? Lymphocytosis Eosinophilia Leukocytosis Neutropenia

Lymphocytosis

Which of the following are cells of the innate immune system? A. Plasma cells B. Natural killer cells C. B lymphocytes D. T lymphocytes

Natural killer cells

Which description best fits the plasma cell? A. High N:C ratio, nuclear chromatin lacy and fine, nucleoli present, agranular cytoplasm B. Nucleus eccentric, chromatin in a cartwheel arrangement, deeply basophilic cytoplasm C. Decreased N:C ratio, nucleus irregular, abundant cytoplasm indented by erythrocytes D. Round nucleus, abundant cytoplasm, cytoplasm contains large pink granules

Nucleus eccentric, chromatin in a cartwheel arrangement, deeply basophilic cytoplasm

A patient with infectious mononucleosis would most likely produce which of the following? Polyclonal antibodies Monoclonal antibodies IgE antibodies IgD antibodies

Polyclonal antibodies

A cell on a Wrights stain peripheral blood smear was observes with a stretched or irregular nucleus; occasional nucleoli were present. The cytoplasm was abundant and scalloped around the erythrocytes. This description best fits the: A. Plasma cell B. Lymphoblast C. Reactive lymph D. Monocyte

Reactive lymph

The commitment of a lymphocyte precursor cell to a T lymphocyte can be defined based on: Rearrangement of the immunoglobulin gene Presence of CD 19 and CD 10 by flow cytometry Rearrangement of the gene loci for the TCR Presence of TdT

Rearrangement of the gene loci for the TCR

An 80% lymphocyte count with a total WBC count of 4.4 X 10^9/L on an adult indicates a: A. Relative and absolute decrease in lymphocytes B. Relative decrease in lymphocytes but an absolute number within the reference interval. C. Relative increase in lymphocytes but an absolute number within reference interval D. Relative and absolute increase in lymphocytes

Relative increase in lymphocytes but an absolute number within reference interval

Lymphocytes can be differentiated from monocytes because lymphocytes have: A. Cytoplasm with fine granules and a lobulated nucleus B. Lacy chromatin pattern with a low N:C ratio C. Low N:C ratio with intense cytoplasmic basophilia D. Round dense chromatin nuclear pattern and sky-blue cytoplasm

Round dense chromatin nuclear pattern and sky-blue cytoplasm

Which of the following is a characteristic of B lymphocytes? A. Regulate immune response B. Synthesize antibody C. Secrete cytokines D. Are majority of peripheral blood lymphocytes

Synthesize antibody

A blood sample from a 5-month-old infant indicates a WBC count of 12.5 × 109/L with 65% lymphocytes. What can you conclude from this? The infant is normal. There is not enough information to draw accurate conclusions. The infant has a malignancy in the lymphocyte lineage. The infant has an infection as indicated by the elevated WBC count

The infant is normal.

The identity of immunoglobulins is determined by: The specificity of the variable region The complexity of the antibody The number of B cells containing the antibody The isotype of the heavy chain

The isotype of the heavy chain

A blood sample from a 40-year-old white female has a WBC count of 10.2 × 109/L and a lymphocyte percentage of 47%. What can be concluded from this? The patient has only an absolute lymphocytosis. The relative and absolute counts are normal. The patient has only a relative lymphocytosis. The patient has both a relative and an absolute lymphocytosis.

The patient has only a relative lymphocytosis.

An instrument printout shows a normal WBC count with a lymphocyte count of 30%. What can be concluded from this? There is a normal lymphocyte concentration. The patient is suffering from an infection. The patient is an infant. The patient has leukemia.

There is a normal lymphocyte concentration.

Which of the following is a characteristic of NK cells? They are capable of antibody synthesis They phagocytize bacteria. They are made up the majority of lymphocytes in peripheral blood. They function in the innate immune response.

They phagocytize bacteria.

The first immunoglobin heavy chain produced in the maturing B lymphocyte is: A. A B. B C. u D. y

u