exam3 - MELATONIN 4
(MELATONIN) MOA
(in the blind) -delay the circadian rhythm when given in the morning 모닝 딜레이 -advance the circadian rhythm when administered in the evening 이브닝 어드벤스
(MELATONIN) DRUG INTERACTION (≥ moderate)
-ANTICOAGULANT/ANTIPLATELET -ANTICONVULSANTS -ANTIDIABETES DRUGS -ANTIHYPERTENSIVE -BENZODIAZEPINES -CAFFEINE -CNS DEPRESSANTS -CONTRACEPTIVE DRUGS -CYTOCHROME P450 1A2 (CYP1A2) -CYTOCHROME P450 2C19 (CYP2C19) -FLUVOXAMINE -IMMUNOSUPPRESSANTS -METHAMPHETAMINE -NIFEDIPINE GITS -SEIZURE THRESHOLD LOWERING -DRUGS -VERAPAMIL (Calan, Covera, Isoptin, Verelan)
(MELATONIN) Interactions w/ Diseases or Conditions
-BLEEDING DISORDERS -CANCER -DEPRESSION -DIABETES -HYPERTENSION -SEIZURE DISORDERS -TRANSPLANT RECIPIENTS
(MELATONIN) USE
-Circadian rhythm sleep disorders in blind children and adults (orphan drug) -Delayed sleep phase syndrome (DSPS) -Sleep-wake cycle disturbances in children and adolescents with developmental disorders
(MELATONIN) part
-hormone from synthetic, animal, or plant -Melatonin from animal sources should be avoided due to the possibility of contamination
(MELATONIN) A/E
-transient depressive symptoms -mild tremor -mild anxiety -abdominal cramps -irritability -reduced alertness -confusion -nausea -vomiting -hypotension *eosinophilia-myalgia syndrome* *Melatonin from animal sources* - *CONTAMINATED*
(MELATONIN) COMMON A/E
-well-tolerated -(NOT frequently than with placebo) daytime drowsiness (20%) headache (7.8%), and dizziness (4%).
(MELATONIN) dose
0.5-5 mg
(MELATONIN) People should not drive or use machinery for
4 to 5 hours after taking melatonin
(MELATONIN) Effectiveness
LIKELY EFFECTIVE
(MELATONIN - short term) SAFETY
LIKELY SAFE (up to 2 months)
(MELATONIN) melatonin secretion
Light inhibits melatonin secretion and darkness stimulates secretion
(MELATONIN) Melatonin suppression by light and age
Melatonin suppression by light is not affected by age 나이와 상관없음
(MELATONIN) Scientific Name
N-acetyl-5-methoxytryptamine Pineal Hormone
(MELATONIN) Nocturnal serum melatonin levels and age
Nocturnal serum melatonin levels naturally decline with increasing pubertal stages
(MELATONIN - long-term) SAFETY
POSSIBLY SAFE (up to 2 years)
(MELATONIN) CHILDREN
POSSIBLY UNSAFE
(MELATONIN) PREGNANCY
POSSIBLY UNSAFE
(MELATONIN) LACTATION
avoid using
(MELATONIN) jet lag, cancer
evening dose
(MELATONIN) bipolar I disorder
melatonin response to light appears to be abnormal
(MELATONIN) Melatonin release peaks between what ages?
one to three years of age
(MELATONIN) melatonin is also produced in
pineal gland and gut
