Med 1 Block 1
smooth
muscle type found in the walls of blood vessles, the GI tract, respiratory tract, and urogenital systems
arrector pili
muscular appendages of the dermis that interact with sympathetic nerve fibers
osteogenesis imperfecta
mutations causing reduced production of type I collagen or production of faulty type I collagen result in this heterogenous group of disorders
cranial nerves
myasthenia gravis is usually observed in muscles affected by these nerves
frontal, maxillary, sphenoid, ethmoid
names of the paranasal sinuses
ATP
negative effector of isocitrate dehydrogenase of TCA cycle
ATP, citrate
negative effectors of PFK-1 of glycolysis
Vx=60 log ([xo]/[xi])
nernst equation
neural ectoderm
nervous tissue is a derivative of what germ layer
Type IV, Type VII
network forming collagen types
substance P
neuropeptide involved in pain relay
opioid peptides, endorphins, vasoactive intestinal peptide
neuropeptide neurotransmitters
opioid peptides
neuropeptides found in the brain and spinal cord; receptors can be bound by morphine and codein
Ach
neurotransmitter of the neuromuscular junction
serotonin
neurotransmitter produced in the GI tract and by neurons of the CNS; acts as a vasoconstrictor, and plays a role in pain perception, sleep regulation, appetite, mood, and anger
Ach
neurotransmitter which is destroyed in the cleft, rather than recycled
synaptic vesicles
neurotransmitters are stored in _______________ near nerve terminals
4th week
neurulation occurs during this week
α1-antitrypsin
neutrophil elastase inhibitor
conductive system
no exchange of gas occurs in this portion of the respiratory system
proteins, cholesterol
non phospholipid membrane components
osteoarthritis
non-inflammatory degenerative joint disease; characterized by pain and stiffness
heme
non-protein prosthetic group of hemoglobin
vasopressin
nonapeptide secreted by posterior pituitary; regulates fluid balance
oxytocin
nonapeptide, secreted by the posterior pituitary, causes uterine contractions
vasopressin
nonapeptide; functions in the regulation of water excretion by kidneys
axoaxonic, somatosomatic, dendritodendritic
nonclassical synapse types
proteasomes
nonmembranous organelle found in the cytoplasm and nucleus; involved in the degradation of proteins
endometrium
normal implantation occurs in the __________ layer of the uterus
posterior superior wall
normal implantation occurs in the____________ of the uterus
telophase
nuclear lamina reassembles during this phase of mitosis
azidothymidine (AZT)
nucleotide analog which terminates chain during DNA synthesis from RNA template (reverse transcriptases)
dideoxyinosine, arabinoside
nucleotide analogs used as chemotherapy for cancer
notochord
nucleus pulposus of intervertebral discs arises from the
145
number of bp which wrap around a histone octamer when histone H1 is not present
8
number of cervical somites
8-10
number of coccygeal somites
5
number of lumbar somites
4
number of occipital somites
5
number of sacral somites
12
number of thoracic somites
diaphysis
nutrient artery of long bone supplies blood to this segment
capacitation
occurs in the female reproductive tract; sperm are incapable of fertilization until it is complete
angiotensin II
octapeptide; hypertensive agent
angiotensin II
octapeptide; stimulates release of aldosterone from adrenal cortex
neural crest
odontoblasts are derived from the
CN I (olfactory)
olfactory receptors converge into this cranial nerve
neural tube
oligodendrocytes are derived from what embryonic feature?
renal abnormalities, renal agenesis
oligohydramnios can indicate
-1/Km
on a lineweaver-burk plot (double reciprocal), the X intercept
1/vmax
on a lineweaver-burk plot (double reciprocal), the Y intercept
Km/vmax
on a lineweaver-burk plot (double reciprocal), the slope
the properties of their side chains
on what basis are amino acids classified?
primary structure
only aspect of protein structure that is not disrupted by denaturation
hysterectomy
only method to remove placenta in placenta accretia
unilateral
only on one side
primary oocytes
oogonia enter meiosis I and undergo DNA replication to form __________
voltage gated channels
open in response to a change in membrane potential
beta-endorphin, enkephalins, dynorphin
opioid peptides
contralateral
opposite sides
nucleus
organelle housing genetic information, has a dual-layered membrane
pancreas, intestines, lungs
organs most commonly affected in Cystic Fibrosis
paraxial mesoderm
origin of somitomeres and somites (35 pairs)
intramembranous
ossification between layers of a membrane; flat bones of the skull are formed this way
endochondral
ossification withing cartilage; long bones are formed by this method
trophoblast
outer cell mass of blastocyst
metaphase II
ovulation occurs when the secondary oocyte has reached this phase of meiosis II
Cystine (disulfide bridge)
oxidation of two adjacent Cysteine units forms this
cystine or disulfide bridge
oxidation of two spatially adjacent cysteine residues forms what?
myoglobin
oxygen storage protein with similar structure to hemoglobin
pI
pH at which an amino acid exists in zwitterionic form
pI
pH where a protein carries a net charge of zero
9.5
pK of an alpha-amino group
2.0
pK of an alpha-carboxyl group
3.9
pK of the beta-carboxyl group of aspartate
10.5
pK of the epsilon-amino group of lysine
4.3
pK of the gamma-carboxyl group of glutamate
12.5
pK of the guanidino group of arginine
6.0
pK of the imidazole group of histidine
neural crest
parasympathetic ganglia of the GI tract are derived from the
increasing potassium permeability at rest
parasympathetic stimulation decreases heart rate by
domatic mesoderm
parietal serosa, dermis of ventral boy, connective tissues of joints and limbs are derived from this layer
cheese, pickled herring, red wine
patients on MAOI should avoid these in their diet
placental abruption
peeling of plaacenta from the uterine wall before birth
enkephalin
pentapeptide; in the brain, can inhibit sense of pain
3-5
percent of hydatiform mole which develop into gestational trophoblastic neoplasia
prosthetic groups
permanently associated coenzymes
CC16
phospholipid secreted by clara cells of terminal bronchi
dephosphorylated
phosphorylase b kinase is inactive when it is in its ______________ state
heat, mixing, xrays, UV radiation
physical causes of denaturation
gases, nutrients, andibodies
placenta exchanges these vital substances between mother and fetus
placenta previa
placenta implants close to cervical os or covers cervical os
progesterone, extrogen, hCG
placenta produces these hormones
formation of primary chorionic villi
placental development by the end of second week
active site
pocket or cleft in enzyme where a reaction takes place
ohabe
poison targeting the sodium/potassium pump
GI abnormalities, esophageal or duodenal atresia, anencephaly
polyhydramnios can indicate
sympathetic
portion of the PNS responsible for increasing cardiac output and dilating pupils, in response to stress
sympathetic
portion of the PNS with ganglia close to the CNS
axial
portion of the skeletal system consisting of skull, spinal column, and bones of the rib cage
appendicular
portion of the skeletal system consisting of the appendages and the shoulder and pelvic girdles
fructose 2,6-biphosphatase
positive effector of PFK-1 of glycolysis
ADP
positive effector of isocitrate dehydrogenase of TCA cycle
protein and RNA
possible strucural components of enzymes
spermiogenesis
postmeiotic series of morphological changes which transform spermatids into sperm
tropoelastin
precursor of elastin, synthesized in RER
acetyl CoA and acetoacetyl CoA
precursors of acetoacetate
elastin
predominant protein of connective tissue
hydatiform mole
preeclampsia during first trimester, elevated hCG, enlarged uterus with bleeding indicate
cleavage of signal sequence
prepro alpha-chains of collagens undergo this change in the RER to become pro alpha-chains
diaphysis
primary ossification center of long bone
agonist
prime mover muscle
infection, heritable mutation
prion causative agents
RER
pro alpha-chains of collagen are synthesized into the lumen of this organelle
spliceosomes
process majority of pre-mRNA; ribonucleoprotein
decatenation
process of untangling entwined DNA fragments after circular DNA replication
gastrulation
process which established the three primary germ layers
gastrulation
process which is first indicated by the formation of the primitive streak within the epiblast
suncytiotrophoblast
produces hCG
product inhibition
product of an enzyme inhibits the enzyme
RU-486, mifepristone, mifeprex
progesterone receptor antagonist
secretory
progesterone stimulates the endometrium of the uterus to enter the _________________ phase
nucleoids
prokaryote DNA is packaged with proteins into structures called
342 glu->lys
prominent abnormality in α1-antitrypsin deficiency
misoprostol, cytotec
prostaglandin E1 analogue
ribosomes
protein factories
hemoglobin
protein that serves in a transport capacity
ferritin
protein; storage form of iron
prion
proteinaceous infectious agent
glycoproteins
proteins found only on the exoplasmic surface
native
proteins must be in this conformation to be active/functional
enzymes
proteins that play a catalytic role
albumin, hemoglobin
proteins that play a role in buffering of extracellular (intravascular) fluid
prothrombin, fibrinogen
proteins that play a role in coagulation
lamin
proteins which line the internal nuclear membrane
cleavage stimulation factor (CstF) and polyadenylation specificity factor (CPSF)
proteins which travel with RNA pol II until the recognize and bind to the stop sequence
actin, myosin, troponin
proteins with a mechanical (motor) function
hormones
proteins/polypeptides that have a regulatory function
Selenocysteine
proteogenic amino acid not coded for by DNA
ferrous ion
proximal His associates to this
Graafian
FSH stimulates the development of a secondary follicle to a ____________ follicle within the ovary
Glutamate replaced by lysine at 6th position of beta chain
Hemoglobin mutation causing HbC
Histidine replaced by tyrosine
Hemoglobin mutation causing HbM
Glutamate replaced by Valine at 6th position of beta chain
Hemoglobin mutation causing HbS (sickle cell anemia)
pH=pKa + log ([A-]/[HA])
Henderson-hasselbach equation
tryptophan is abundant in environment
Trp operon is always expressed except under these conditions
Hydroxyproline, Hydroxylysine
Two modified amino acids found in collagen
barr body, centromeres, telomeres
constitutive heterochromatin examples
nucleoplasm
contents surrounded by inner nuclear membrane
aromatic aa decarboxylase
converts 5-hydroxytryptophan to 5-hydroxytryptamine (5-HT; serotonin)
SS dehydrogenase
converts succinate semialdehyde to succinate, in GABA breakdown pathway
mismatch repair
corrects misincorporated bases during DNA replication; binds at misincorporated base and scans for end of okazaki fragement to determine which strand is incorrect
epithelium
covers/lines all body surfaces (internal and external
neural crest
cranial nerve ganglia are derived from the
protein synthesis
antibiotics acting on the bacterial ribosome inhibit this vital intracellular process
PCNA
antibody staining for this protein, associated with DNA replication, is used for grading the stages of cancer growth
5-fluorouracil
anticancer drug that inhibits thymidylate synthase
dopamine D2 receptors
antipsychotics (phenothizines, haloperidol) inhibit these receptors
acyclovir
antiviral that works by inhibiting viral DNA polymerases
lumen or external enviroment
apical surface of an epithelial tissue faces the
nucleolus
appears as a dot within the nucleus
goldman equation
application of nernst equation using the gradients of each ion and weighted by permeability
doppler
application of ultrasound technology used to visualize vascular structures
prochordal plate
area where the epiblast and hypoblast fuse; future site of the mouth
phenylalanine, tryptophan, tyrosine, histidine
aromatic amino acids
terminal arteries
arteries that lack anastomoses; blockage causes tissue death
alzheimer disease
associated with misfolded beta-amyloid precursor protein accumulations in brain
placenta previa
associated with repeated episodes of bright red bleeding in third trimester
placenta accretia
associated with vaginal bleeding at second trimester or later
type A spermatogonia
at purberty, primordial germ cells deifferentiate into
secondary spermatocytes
at the end of meiosis I, primary spermatocytes split to form 2
tertiary chorionic villi/definitive placental villus
at the end of the third week, small capillaries arise in the mesodermal core of the secondary chorionic villi forming
origin
attachment of muscle that is fixed during contration
insertion
attachment of muscle that moves during contraction
multiple sclerosis
autoimmune attack on oligodendrocytes of the CNS, irreversible, progressive, terminal
guillian-barre syndrome
autoimmune attack on the schwann cells of the PNS; reversible
myasthenia gravis
autoimmune disease of the neuromuscular junction in which Ach receptors are destroyed by antibodies
achondroplasia
autosomal dominant skeletal anomaly characterized by retarded bone growth in the limbs with normal sized head and trunk
zellweger syndrome
autosomal recessive disease caused by inability to assemble normal cellular peroxisomes; range of disorders characterized by neurological abnormalities
distal
away from the attachment
dorsum
back of foot or hand
nucleosome
basic unit of organization of DNA; wrapped around a histone octamer
cell
basic unit of the body
inferior/caudal
beneath, anatomically
chordoma
benign or malignant tumor arising from the remnants of the notochord; usually intercranial or sacral and more common in men>50yo
ultrasound
best first radiological exam in the pediatric population, when appropriate
interediate mesoderm
between paraxial and lateral plate mesoderm
diazepam (benzodiazepines)
bind to GABA receptors and cause potentiation of the response to endogenous GABA
metabotropic
binding of neurotransmitters can be G coupled receptors and may use second messengers to affect ion channels indirectly
ionotropoid
binding of neurotransmitters causes flow of ions through a channel in this receptor class
SSB single strand binding protein
binds to ssDNA to protect it from nucleases during replication
enzymes
biological catalysts
bilipid membrane
biological membrane composed of two layers of lipid
alpha latrotoxin
black widow spider venom component
eight-cell
blastomeres are considered totipotent up to this stage
retinal
blockage of this artery results in blindness
histamine
blockers of these amines tend to have a sedative effect
bilateral
both sides
plantar
bottom surface of foot
valine, leucine, isoleucine
branched chain amino acids
5-hydroxyindole acetic acid (5-HIAA)
breakdown product of serotonin; secreted in urine
acetylcholine esterase
breaks down acetylcholine
osteogenesis imperfecta
brittle bones, blue sclera, abnormal tooth development, and hearing abnormalities are associated with
histidine
buffering action of hemoglobin is attributed to this amino acid residue
epicondyle
bump near a condyle
collagen
bundled into parallel fibers i tendons to provide strength
first degree
burn affecting only the superficial part of the epidermis
second degree
burn extending into the dermis
third degree
burn which extends past dermis to fascia, muscle, or bone
cytotrphoblast
by the end of the 4th month, this component of the placenta disappears
44
by the end of the 5th week, ______________ pairs of somites form
ultrasound
can be used for real-time biopsies, and to distiguish cystic vs solid lesions
nucleotide analogs
can be used to block DNA sythesis
Sanger's reagent (FDNB) or Dansyl Chloride
can be used to identify the N terminal amino acid
carcinoma
cancer of epithelial tissue
8-28 hours
cardiac troponins peak __________ hours after MI
7 days
cardiac troponins return to normal _______ days after MI
4-6 hours
cardiac troponins rise _____ hours after MI
cAMP
catabolic activator protein (CAP) of lac operon system needs this cofactor to bind to the promotor
sympathetic
catabolic portion of the PNS
dopamine, norepinephrine
catecholamine neurotransmitters of the brain and ANS
sirenomelia
caudal dysgenesis is also called
mutations, nutritional deficits, viral or bacterial pathogens
causative agents of enzyme deficiency
thin sclera shows veins
cause of blue sclera observed in some forms of osteogenesis imperfecta
tetany of diaphragm; respiratory arrest
cause of death from black widow bites in children and small animals
paralysis, respiratory arrest
cause of death in botox poisoning
Ehler's-danlos syndrome
caused by deficiency of collagen processing enzymes, or mutation of amino acid sequences for collagen types I, III, or V
idopathic (perhaps genetic), pesticides, manganese, antipsychotics, head trauma
causes of parkinson's disease
delay in reopening of Na+ inactivation gates
causes the absolute refractory period
hyperpolarization due to open K+ channels
causes the relative refractory period
meiosis
cell division that occurs only during the production of gametes
intercalated disc
cell to cell gap junctions in myocardium
germ cells, stem cells, lymphocytes
cell types where telomerases are normally present
squamous epithelium, clara cells, brush cells
cells found in the lining of the respiratory bronchus
clara cells
cells of terminal bronchi which secrete CC16
astrocytes
cells of the CNS which form the blood brain barrier
schwann cells
cells of the PNS, many of which myelinate a single axon
hypoblast
cells of this layer migrate and line the inner surface of the cytotrophoblast, forming the yolk sac
fibroblasts, chondroblasts, osteoblasts
cells responsible for synthesis of collagen polypeptide precursors
wbc's, macrophages, fibroblasts, mast cells, neutrophils, plasma cells, adipose cells
cells that can be found in areolar tissue
ependymal
cells which line the ventricles of the CNS
axons, muscles
cells with excitable membranes
chloride and fluid secretory capacity
cellular function disrupted in Cystic Fibrosis
tRNA
central to protein synthesis as adapters between mRNA and amino acids
2-α1, 1-α2
chain composition of type I collagen
3-α1
chain composition of type II collagen
glycine and proline
chains of collagen are rich in these two amino acids
nuclear pores
channels for communication and transport from nucleus to cytoplasm and vice versa
pores
channels which increase permeability for specific substances
acids, alkali, organic solvents, heavy metal salts
chemical causes of denaturation
acetylations, methylations, phosphorylations, rearrangements, copy numbers
chromatin modifications playing a role in gene control
mitochrondria
citric acid cycle and fatty acid oxidation occur in the lumen of this organelle
chaperonins
class of chaperones that use energy from ATP to facilitate folding
Axosomatic, Axodendritic
classic synapse types
central, peripheral, autonomic, ganglia, nerves, neurons, glia
classifications of nervous tissue
bruising on limbs, connective tissue fragility
clinical signs of scurvy
bursae
closed, fibrous sacs that form where tendons rub against bone
homeodomain proteins
coded by HOX genes; regulate genes responsible for development
PLP
coenzyme of ALT
NADP+
coenzyme of Glucose-6-PDH
NAD+
coenzyme of LDH
cobalamin
coenzyme of methionine synthase
TPP
coenzyme of transketolase
copper, manganese
cofactors of superoxide dismutase
cross linking
collagen fibrils must undergo this process to become mature collagen
scurvy, ehlers-danlos syndrome, osteogenesis imperfecta
collagenopathies of clinical importance
alkylation, oxidation, deamination, cytosine to uridine, adenine to hypoxanthine
common chemical changes to DNA
hyaline cartilage, synovial membrane, synovial fluid, fibrous capsule, ligaments
common components of a synovial joint
TATAAT
common consensus sequence in prokaryotes, also called Pribnow box
SSRI, MAOI, 5-HT supplements
common drug classes used in treatment of depression
US, radiograph, CT, MRI, PET
common imaging modalities
CAAT, TATA boxes
common promotor sequences in eukaryotes
retrouterine pouch (pouch of douglas)
common site for ectopic abdominal pregnancy
right side near median plane
common site of lateral folding defects
cigarette smoke, byproducts of metabolism, foods, reactive oxygen species, radiation
common sources of DNA damage
syncytium
communicating tube between adjacent cardiac muscle cells
increasing substrate concentration
competitive inhibition can be overcome by doing this
dicumarol
competitive inhibitor of Vitamin K epoxide reductase used as an anticoagulant
methotrexate
competitive inhibitor of dihydrofolate reductase used in treatment of cancers
sulfanilamide
competitive inhibitor of dihydropteroate synthase which prevents bacterial synthesis of folic acid; used as antibiotic
clomiphene citrate
competitive inhibitor of estrogen in the adenohypophysis
captopril, enalapril
competitive inhibitors of Angiotensin converting enzyme used to lower blood pressure
statins
competitive inhibitors of HMG CoA reductase used to treat hypercholesterolemia
synergist
complements action of prime mover muscle
dislocation
complete displacement of bones at a joint
3 allysyl, 1 lysyl
components of a desmosine cross link
type II collagen, elastic fibers, aggrecan
components of elastic cartilage extracellular matrix
types I and II collagen, versican
components of fibrocartilage extracellular matrix
ferrous ion and protoporphyrin IX
components of heme
type II collagen, aggrecan
components of hyaline cartilage extracellular matrix
psudostratified ciliated columnar epithelium with goblet cells, basement membrane, lamina propria, muscularis mucosa
components of mucosa of secondary and tertiary bronchi
pseudostratified ciliated columnar epithelium, basal lamina, lamina propria
components of mucosa of trachea
myofibers, myofibrils, myofilaments, sarcomeres, sarcolemma, sarcoplasm, sarcplasmic reticulum
components of muscle tissue
sustentacular (columnar) cells, basal cells, nerve cells, glands
components of olfactory epithelium
DNA, helicase, SSB
components of prepriming complex in prokaryotic DNA replication
ectoderm, mesoderm, endoderm
components of the trilaminar embryonic disk
small layer of connective tissue
components of the tunica adventitia of small arteries
squamous epithelium, basal lamina
components of the tunica intima of arterioles
1-2 layers of smooth muscle
components of the tunica media of small arteries
sigma factor, RNA polymerase
components of transcription complex in prokaryotes
emery-dreifuss muscular dystrophy
condition that chiefly affects muscles; characterized by progressive contractures which develop in childhood; result of a mutation to emerin protein, which is a part of the nuclear lamina
trauma, stroke, severe convulsions, huntington's chorea
conditions which can cause increased extracellular glutamate
bowel gas, large body habitus, examiner skill
conditions which can interfere with ultrasound exam quality
saltatory
conduction that "jumps" from node to node
FAD
conenzyme of D-AA oxidase
FMN
conenzyme of L-AA oxidase
Lipoic acid
conenzyme of PDH complex
CoA
conenzyme of Thiokinase
FH-4
conenzyme of formyl transferase
Biotin
conenzyme of pyruvate carboxylase
neural crest
connective tissue and bones of the face and skull are derived from the
mesenchyme
connective tissue is a derivative of what germ layer?
begin with GU, end with AG
consensus sequences for splicing, in eukaryotes
exon skipping, truncated exons
consequences of splicing errors
stratified squamous
consists of multiple layers of flattened cells, the deepest layer of which consists of basal cells, which are attached to the basal lamina
ramus
curved portion of bone (like a ram's horn)
lewy bodies
cytoplasmic inclusion bodies seen in substantia nigra in parkinson's disease
fluid surrounding cellular organelles
cytosol
high serum CC16
damage to the terminal bronchiole is indicated by this value
reactive oxygen species
damaged mitochondria release these, in excitotoxicity
zygote
day 0 of development, fetus is called
kalladin
decapeptide vasodilator
oligohydramnios
decreased amniotic fluid; less than 400mL
repression
decreases the rate of enzyme biosynthesis
hereditary nonpolyposis colon cancer (lynch syndrome)
defect in mismatch repair makes affected persons prone to colon, stomach, intestinal, and ovarian cancers
vascular ehler-danlos syndrome
defect of type III collagen causes arterial rupture in this more severe form of an autosomal dominant collagenopathy
ataxia telangiectasia
defective detection of DNA breaks; affected persons show neurological, immunological and developmental problems and have and increased risk of cancer
gastroschisis; epigastric hernias
defective development of anterior abdominal wall with abdominal contents herniating through the gap
xeroderma pigmentosum
defective nucleotide excision repair; UV damage and bulky adducts cannot be repaired, making sufferers sensitive to sun exposure and prone to skin cancer
repair of DNA strand breaks
defective process in BRCA1 and BRCA2
DNA strand break detection
defective process in ataxia telangiectasia
mismatch repair
defective process in hereditary nonpolyposis colon cancer (lynch syndrome)
nucleotide excision repair
defective process in xeroderma pigmentosum
BRCA1, BRCA2
defective repair of DNA strand breaks increases risk of breast, ovarian, and prostate cancers
liver, cirrhosis
defective α1-antitrypsin may undergo polymerization in this organ resulting in this associated disease
impairs interchain hydrogen bond formation, prevents crosslinking of collagen fibrils
deficiency of Vitamin C has two specific end effects on collagen formation
dopamine, serotonin
deficiency of aromatic aa decarboxylase causes deficiency of these two neurotransmitters
tyrosine hydroxylase
deficiency of this enzyme can be treated with administration of L-dopa with peripheral aromatic amino acid decarboxylase ihibitor
vasopressin (ADH)
deficiency of this is associated with diabetes insipidus
alveoli of lungs
deficiency of α1-antitrypsin can have negative effects on this particular anatomical structure
emphysema
deficiency or dysfunction of α1-antitrypsin is associated with this type of COPD
homovanillic acid
degradation product of dopamine
peroxisome
depending on cell type, this organelle can participate in many of the same functions as the SER, including cholesterol synthesis and alcohol detoxification
ectoderm, mesoderm, endoderm
derivatives of epiblast
wall of digestive and respiratory tracts (not epithelium), visceral serosa, heart, and blood vessels
derivatives of splanchic mesoderm
epithelial lining of glands, digestive, and respiratory tracts
derivatives of the endoderm
notochord, somites, intermediate mesoderm, lateral plate mesoderm
derivatives of the mesoderm
parietal serosa, dermis of ventral body, connective tissues of limbs (bones, joints, ligaments)
derivatives of the somatic mesoderm
neural crest
dermis and smooth muscles of blood vessels of the face, neck, and forebrain are derived from the
dermatome
dermis of the dorsal body region arises from the ______________ layer of the somites
gametes
descendents of primordial germ cells
alzheimer's
destruction of the nucleus basilis has been linked with this disease
feedback inhibition
end product of a pathway inhibits a key enzyme earlier in the pathway
death from cardiac arrest
end result of blocking of sodium activation gates by tetrotoxin
NADH-metHb reductase
enzyme responsible for converting heme ferric ions to ferrous ions
HAT
enzyme responsible for histone acetylation
HDAC
enzyme responsible for histone deacetylation
lysil hydroxylase
enzyme responsible for hydroxylation of lysine residues
prolyl hydroxylase
enzyme responsible for hydroxylation of proline residues
MAO
enzyme that breaks down serotonin (5-hydroxytryptamine; 5-HT)
catalase
enzyme that converts hydrogen peroxide to water and oxygen
glucose oxidase
enzyme that reacts with glucose and provides an expedient method for the measuring of blood or urine glucose
ALP
enzyme useful in diagnosis of bone disorder
5'nucleotidase 5'NT
enzyme useful in the diagnosis of obstructive jaundice
DNA topoisomerase IV
enzyme which cuts and re-seals double stranded DNA in prokaryotes; completes decatenation after replication
phenylethanolamine N-methyl transferase (PNMT)
enzyme which methylates noreipinephrine to epinephrine
transition state
enzymes generally stabilize this state, resulting in a reduced activation energy barrier and speeding progression towards equilibrium
collagenases
enzymes responsible for breakdown of collagen
CK-MB, LDH-1, AST
enzymes useful in diagnosis of MI
amylase, lipase
enzymes useful in diagnosis of acute pancreatitis
ALP, GGT
enzymes useful in diagnosis of cholestasis
total LDH
enzymes useful in diagnosis of hemolytic anemias, cancers
ALT, AST, LDH
enzymes useful in diagnosis of hepatitis
ACP, PSA
enzymes useful in diagnosis of prostatic carcinoma
total CK
enzymes useful in the diagnosis of muscle dystrophies
isoenzymes
enzymes which catalyze the same reaction
monoamine oxidase (MAO) and catechol O-methyl transferase (COMT)
enzymes which degrade dopamine in the synaptic cleft
phosphorylases
enzymes which perform dephosphorylation
kinases
enzymes which perform phosphorylation
metanephrine
epinephrine is converted to _____________ by COMT
dihydroxymandelic acid
epinephrine is converted to ______________ by MAO
proteins
epithelial cells are anchored to the basement membrane by these
endoderm
epithelial lining of glands, digestive, and respiratory tracts are derived from this layer
simple epithelium
epithelium consisting of a single layer of cells
proliferative
estrogen stimulates the endometrium of the uterus to enter the ____________ phase
cancer
eukaryote topoisomerase inhibitors are used primarily for the treatment of
gene expression
eukaryotic cells are differentiated based on
Trp operon
example for negative control of transcription in prokaryotes
Nicotinic Ach receptor
example of a ionotropoid receptor
shoulder, hip
example of ball and socket joint
Lac operon
example of both positive and negative control in prokaryotes
metacarpophalangeal joint
example of condyloid joint
tendons
example of dense regular connective tissue
epiphyseal plate, first chondrosternal joint
example of primary cartilaginous joints
first metacarpal joint
example of saddle joint
aorta, pulmonary artery
examples of elastic arteries
immunoglobulins, transferrin, ceruloplasmin, TSH
examples of glycoproteins
elbow, ankle, interphalangeal
examples of hinge joints
dermis, submucosa
examples of irregular dense connective tissue
HDL, LDL
examples of lipoproteins
radial, ulnar veins
examples of medium sized veins
beta-adrenergic, muscarinic Ach receptors
examples of metabotropic receptors
Transferrin, ceruloplasmin, hemoglobin
examples of metalloproteins
radial, ulnar, femoral, tibial
examples of muscular arteries
superior radio-ulnar joint, atlanto-axial joint
examples of pivot joints
sternoclavicular, acromioclavicular
examples of plane joints
alpha helix, beta sheets, turns
examples of protein secondary structure
hemoglobin, lactate dehydrogenase, immunoglobin, insulin receptor
examples of proteins exhibiting quaternary structure
alpha-keratin, hemoglobin, myoglobin
examples of proteins with extensive alpha helical structure
symphysis pubis, manubriosternal, intervertebral joints
examples of secondary cartilaginous joints
superior and inferior vena cava
exaples of large veins
excitotoxicity
excess extracellular glutamate can lead to
polyhydramnios
excess of amniotic fluid; 1500-2000mL
mitochondria
excessive intracellular Ca++ causes damage to this organelle, in excitotoxicity
voltage gated
excitable cells posess _____________ channels
fibrocartilage
forms sternoclavicular and temporomandibular joints
hyaline cartilage
forms the articular surfaces of synovial joints
intermediate mesoderm
forms urogenital system
avulsion
fracture where bone is torn away from its attachment point
classical ehler-danlos syndrome
fragile, stretchy skin, loose joints, easy bruising
N-terminal amino acid of globin chains
free glucose binds here to form HbA1C
snRNA
function in a variety of nuclear processes, including the splicing of pre-mRNA
inhibition, facilitation
functions of axoaxonic synapses
channels, receptors, linkers, enzymes
functions of membrane proteins
gene
fundamental unit of heredity located in the chromosome
23
gametes have _______________ chromosomes
communication
gap junctions on extended processes allow osteocytes to perform this function
NO, nitric oxide
gas neurotransmitter
lateral folds
gastroschisis and epigastric hernias are due to faulty development of
3rd week
gastrulation occurs during this week
choline
general chemical class of phospholipid CC16
lipoprotein
general chemical class of surfactant
premature aging, cancer
general consequence of DNA repair mechanism failure
mucosa, submucosa, cartiage
general layers of tissue in secondary and tertiary bronchi
recognition, excision, replacement, ligation
general mechanism of DNA repair
Gly-X-Y
general structure of AA sequence of a collagen chain
proline
generally follows glycine in AA sequence of collagen chain
Hutchinson Gilford progeria
genetic condition characterized by the dramatic, rapid appearance of aging beginning in childhood; associated with a mutation of Lamin A, part of the nuclear lamina
dopamine
genetic defects in the enzymes of the synthesis pathway for this catecholamine result in progressive gait disorder and infantile parkinsonism
mesoderm (mesenchyme)
germ layer from which bone arises
sweat glands
glandular appendages of the dermis that secrete a thin, watery fluid that functions in homeostasis of body temperature
sebaceous glands
glandular appendages of the dermis that secrete an oily, lubricating substance
microglia
glial cells of the CNS that respond to tissue damage by forming large amoeboid phagocytic cells
oligodendrogliocytes
glial cells of the CNS which are destroyed in multiple sclerosis
oligodendrogliocytes
glial cells of the CNS; myelinate multipe axons
α1-antitrypsin
globulin plasma protein synthesized in liver; inhibits proteolytic enzymes such as trypsin and elastase
NMDA
glutamate receptors involved in excitotoxicity
A1C
glycated hemoglobin
phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine
glycerophospholipids
dephosphorylated
glycogen phosphorylase is inactive when it is in its ______________ state
phosphorylated
glycogen syntase is inactive when it is in its ______________ state
hCG
glycoprotein produced by the syncytiotrophoblast
estrogen
granulosa cells of the secondary and graafian follicle secrete
sulcus
groove, crevice, or furrow in bone
complete hydatiform mole
gross edema of chorionic vill forming grape-like, transparent vesicles, hyperplastic proliferation of trophoblastic cells, absence of fetus
amyloidosis
group of diseases arising due to deposition of amyloid proteins in organs or tissues
motor unit
group of muscle fibers enervated by the axonal terminals of a single nerve
charcot-marie-toothe
group of varied inherited disorders of the peripheral nervous system characterised by progressive loss of muscle tissue and touch sensation across various parts of the body
plus end
growing end of a microtubule assembly
syncytiotrophoblast
grows into the endometrium to make contact with endometrial blood vessels and glands
phrenic nerve
guillian barre can result in respiratory failure due to demyellination of what nerve?
day 8
hCG can be detected in blood on
day 10
hCG can be detected in urine on
several years
half life of collagen molecules
nails
hard keratinized appendages of the dermis
arteriosclerosis
hardening of arteries
anserine
has an antioxidant effect 5x greater than its relative, carnosine
ATP
helicase uses energy from this source to separate DNA strands
R
hemoglobin form that favors oxygen binding
T
hemoglobin form that favors oxygen dissociation
creutzfeldt-jacob disease
heritable prion disease, caused by mutation
neural tube defects, body wall defects
high alpha fetoprotein on amniocentesis can indicate
transition state
high energy intermediate that occurs during the formation product
low
high enzyme affinity for substrate is characterized by _______ Km
hCG
high levels can indicate multiple pregnancy, hydatiform mole, gestational trophoblastic neoplasia (choriocarcinoma)
arteries
high pressure vessels which carry oxygenated blood from heart; except pulmonary
terminal bronchiole
high serum CC16 indicates damage to what structure
H1
histone associated with linker DNA; involved with formation of heterochromatin from euchromatin
chromatin assembly factors (CAF1) and nucleosome assembly proteins (NAP1)
histone chaperones which mediate reassembly of histones after replication
lys, arg
histones are rich in these aa residues
gonadotropin-releasing hormone (GnRH)
hormone secreted by the hypothalamus; regulates female reproductive cycle
dephosphorylated
hormone sensitive lipase is inactive when it is in its ______________ state
limit unproductive folding
how do chaperones facilitate recovery of native structure?
oxidative damage to methionine residues prevents binding of α1-antitrypsin to elastase
how does smoking cause emphysema?
densities
how findings on CT are described
1000
how long is a typical AA chain of collagen?
141
how many AA in alpha chain of Hb?
146
how many AA in beta chain of Hb
4
how many amino acids are usually present in a turn?
2
how many arteries in a normal umbilical cord
3
how many capillary types are there?
4
how many heme per molecule of Hb?
2
how many hydrogen ions does hemoglobin transport from the peripheral tissues to the lungs?
4
how many layers is the air-blood barrier
1
how many oxygen can myoglobin store?
4
how many oxygen can one hemoglobin transport?
12
how many pairs of cranial nerves
31
how many pairs of spinal nerves
8
how many pairs of spinal nerves originate in the cervical segment
5
how many pairs of spinal nerves originate in the sacral region
8, 4 on each side
how many paranasal sinuses are there
3.6
how many residues per turn in alpha helix
1
how many spinal nerve pairs exit at the coccygeal level
12
how many spinal nerve pairs originate in the thoracic segment
1
how many veins in a normal umbilical cord
5
how may spinal nerve pairs originate in the lumbar segment
polyadenylation
how the "tail" of mRNA is formed
long bone
humerus and phalanges fall in this general class of bone
beta sheets
hydrogen bonds between adjacent peptide segments stabilize this secondary structure
4th
hydrogen bonds occur between every _________ peptide in the linear sequence to form alpha helix
ascorbate
hydroxyl group donor for synthesis of norepinephrine from dopamine
tetrahydrobiopterin
hydroxyl group donor in the first step of serotonin synthesis
dopamine beta hydroxylase
hydroxylates dopamine to form norepinephrine
tryptophan hydroxylase
hydroxylates tryptophan in the first step of serotonin synthesis
Ascorbic Acid, Vitamin C
hydroxylation of lysine and proline residues of collagen is dependent on this vitamin
gallstones
hyperechoic structures within the gallbladder on ultrasound
complete hydatiform mole
hyperplastic proliferation of trophoblast after death of embryblast; caused by "empty egg" being fertilized by a haploid sperm which then duplicates (46,XX)
partial hydatiform mole
hyperplastic proliferation of trophoblast after fertilization of egg by two sperm (69,XXX or XXY)
prolactin
hypothalamic dopamine inhibits release of this by anterior pituitary
proline
imino acid
placenta accretia
implantation in the myometrium
allactose
in Lac operon mechanics, this substance binds to the repressor, releasing it from the Lac operon and allowing transcription
brain
in a head CT, this serves as the density of reference (isodense)
PCNA proliferating cell nuclear antigen
in eukaryotes, clamps DNA pol delta and epsilon to DNA, increasing processivity
Ligase I
in eukaryotes, joins DNA fragments
RNAse H
in eukaryotes, removes RNA primer
ORC origin recognition complex
in eukaryotes, this complex binds to the origin of replication
polymerase delta
in eukaryotes, this polymerase elongates the lagging strand; has proofreading capability
polymerase epsilon
in eukaryotes, this polymerase elongates the leading strand; has proofreading capability
polymerase beta
in eukaryotes, this polymerase functions in DNA repair; lacks 3' to 5' exonuclease activity
polymerase alpha
in eukaryotes, this polymerase is complexed with a primase; initiates replication; lacks 3' to 5' exonuclease activity
polymerase gamma
in eukaryotes, this polymerase replicates mitochondrial DNA; has proofreading capability
prophase I
in females, primary oocytes are dormant in _________ until puberty
oogonia
in females, primordial germ cells differentiate into _________ after arriving in the ovary at week 4
week 4
in females, primordial germ cells from the wall of the yolk sac arrive in the ovary at what week of embryonic development
sarcoplasmic reticulum
in muscle cells, the SER is modified to perform the specialized function of calcium ion storage and is called
A and T
in prokaryotes, the oriC (origin of replication) is usually rich in these nucleotides
DNA pol I
in prokaryotes, this polymerase excises RNA primer and replaces it with DNA
DNA pol I
in prokaryotes, this polymerase has 5' to 3' exonuclease activity and functions in DNA repair
DNA pol III
in prokaryotes, this polymerase has high processivity and functions mostly in DNA replication
DNA pol II
in prokaryotes, this polymerase has moderate processivity and can reinitate a replication fork stalled by repair; also functions in DNA repair
DNA pol III
in prokaryotes, this polymerases adds nucleotides onto the short RNA primer
FSH and LH
in response to GnRH, the adenohypophysis secretes
SER
in response to challenge with lipophilic drugs, hepatocytes increase the size of this organelle
brown
in severe cases of methemoglobinemia, the blood of the affected individual will be this color
nucleus
in the CNS, a collection of cell bodies
ganglion
in the PNS, a collection of nerve cell bodies
week 4
in the male, primordial germ cells from the wall of the yolk sac arrive in the testes at ________ of embryonic development
puberty
in the male, primordial germ cells remain dormant until
cuboidal epithelium
in the terminal bronchi, the pseudostratified ciliated columnar epithelium of the tertiary bronchi transitions into
hypoxia-high altitude, pulmonary obstructive disorders, chronic anemia
in these conditions, concentration of 2,3-BPG is increased
parkinson's disease
in this disease, dopamine defiiency results in progressive termor, bradykinesia, rigidity, and postural instability
MRI
in this exam, the scanner creates a strong magnetic field which sends radiofrequency pulses through body tissues
negative control
in this type of gene expression control, a repressor binds to a sequence within the promotor, preventing binding of transcription complex
positive control
in this type of gene expression control; transcription is mediated by activators, without which little or no transcription takes place
subluxation
incomplete or partial separation of a joint; contact between articular surfaces is retained
pheochromocytoma
increased urinary excretion of vanillylmandelic acid and metanephrines is diagnostic for
induction
increases the rate of enzyme biosynthesis
A1C
indicator of average blood sugar over preceding two months
lymphadenitis
inflammation of lymph nodes
lymphangitis
inflammation of lymphatic vessels
rheumatoid arthritis
inflammatory autoimmune joint disease, characterized by joint swelling, stiffness, and pain
autosomal dominant
inheritance pattern of ehler's danlos syndrome
autosomal dominant
inheritance pattern of osteogenesis imperfecta
camptothecin
inhibitor of eukaryote type I topoisomerases
etoposide
inhibitor of eukaryote type II topoisomerases
allopurinol
inhibitor of xanthine oxidase used in the treatment of gout
suicide inhibitors
inhibitors which participate in an intermediate step of a catalytic reaction and become converted to a more effective inhibitor
glycine
inhibitory neurotransmitter in the spinal cord, brainstem, and retina; co-agonist with glutamate for NMDA receptors
penicillin
inhibits enzyme transpeptidase involved in bacterial cell wall synthesis
RU-486, mifepristone, mifeprex
initiates menstruation when taken within 8-10 weeks of the start of last menstrual period
embryoblast
inner cell mass of blastocyst
fibrillin
interacts with elastin in connective tissues
C-terminal
interchain disulfide bonds at this site start the assembly of collagen quaternary structure
Glial fibrillary protein (GFAP)
intermediate filament of brain astrocytes and glial cells
vimentin
intermediate filament of mesoderm and fibroblasts; present in connective tissues
desmin
intermediate filament of muscle
perhiperin
intermediate filament of peripheral nerve cells
lamin
intermediate filament which lines the internal nuclear membrane
keratin
intermediate filament; found in nails and hair
neurofilaments
intermediate filaments of varying sizes present in the nervous system
cytosol
intracellular colation of glycolysis, HMP shunt, and FA synthesis
Nucleus
intracellular location of DNA and RNA synthesis
lysosome
intracellular location of degradation of complex macromolecules
smooth
involuntary, nonstriated muscle
hydroxylysine
involved in the enzymatic glycosylation of collagen
sarin
irreversible inhibitor of acetylcholinesterase
disulfam
irreversible inhibitor of aldehyde dehydrogenase used in the treatment of alcoholism
no
is calcification a normal process in adults?
secondary cartilaginous
joints comprised of fibrocartilage, even in adults
temperature
kinetic energy in biological systems is expressed in terms of
trochanter
large, blunt, bump-like projection; larger than a tuberosity
tuberosity
large, rounded or oblong projection; smaller than a trochanter but larger than a tubercle
somatic/parietal
lateral plate mesoderm covering of the amnion
splanchic/visceral
lateral plate mesoderm covering of the yolk sac
somatic and splanchic mesoderm
lateral plate mesoderm gives rise to
ectoderm
layer from which brain and spinal cord, and neural crest are derived
ectoderm
layer from which epidermis, hair, nails, and glands of skin are derived
mesoderm
layer from which notochord, somites, intermediate and lateral plate __________ arise
endothelial cells, incomplete basal lamin
layers of lymphatic vessels
extraembryonic somatic mesoderm, cytotrophoblast, syncytiotrophoblast
layers of the chorion
pseudostratified ciliated columnar epithelium with goblet cells, basement membrane, lamina propria
layers of tissue at the level of the nostrils
mucosa, submucosa, cartilage
layers of trachea
corona radiata, zona pellucida
layers which must be penetrated by the sperm for fertilization to occur
50cm
length of normal umbilical cord at term
alpha-synuclein
lewy bodies are composed of aggregates of ______________ in the substantia nigra
capillary bed
lies between arterioles and venules
spine
like a crest but raised higher; sharp, pointed, slender projection of bone
NMJ
likely location of problem when strength is decreased, tone/reflexes are normal, and strength rapidly decreases with use (fatigueability)
langers/tension/cleavage lines
lines created by collagen in the skin; exploited by surgeons to reduce scarring
extraembryonic somatic mesoderm
lines the cytotrophoblast, forms connecting stalk, covers the amnion
extraembryonic visceral mesoderm
lines the outer portion of the yolk sac
beta chains
location of 2,3-BPG binding sites
centrosome
location of centrioles
ampulla of the uterine tube
location of fertilization
between substantia nigra and corpus striatum
location of nigrostriatal fibers
PNS
location of problem when strength is decreased and tone/reflexes are reduced
CNS
location of problem when strength is decreased but tone/reflexes are increased
F8
location of proximal His in Hb
liver, spleen, bone marrow
locations of discontinuous capillaries
kidney glomerulus, gallbladder, intestines, and endocrine glands
locations of fenestrated capillaries
neostigmine
long acting inhibitor of acetylcholinesterase
amyloids
long fibrillary insoluble protein aggregates with extensive beta pleated structures
fissure
long, crack or hole on a bone in which a blood vessel and nerve would usually sit
areolar
loose connective tissue is also called
Cystic Fibrosis
loss of a single phenylalanine in the CFTR protein causes this disease
high
low enzyme affinity for substrate is characterized by ________ Km
hCG
low levels can indicate spontaneous abortion or ectopic pregnancy
veins
low pressure blood vessels with unidirectional valves; usually carry deoxygenated blood
nervous system
lysosomal storage disorders affect this system catastrophically
dust cells
macrophages of the alveoli are also called
sodium-potassium pumps
maintain the Na/K dispersion across living membranes
GABA
major inhibitory neurotransmitter of the CNS
glycerophospholipids, sphingolipids
major membrane phospholipid types
nucleus basilis
major producer of Ach
rRNA
makes up about 80% of RNA in cells
heat shock proteins
many chaperones belong to this class of proteins
decidua basalis
maternal portion of the placenta
action potential
means of signal amplification in biological membranes to prevent diminishment of a signal as it travels around the membrane
prolactin
measurement of serum __________ is useful in monitoring of central dopamine correction
Levodopa/carbidopa; dopamine receptor agonists, MAO-B inhibitors, dopamine reuptake inhibitors
medication classes for treatment of parkinsons
limbs
medium veins have one way valves in these areas
lysosome
membrane bound organelle with single membrane; membrane has proton pumps which lower the pH inside the organelle
lysosome
membrane bound organelle; contains digestive enzymes
phosphatidylserine
membrane phospholipid found exclusively in the inner leaflet
phosphatidylinositol, phosphatidylethanollamine
membrane phospholipids found mostly in the inner leaflet
phosphatidylcholine, sphingomyelin
membrane phospholipids found mostly in the outer leaflet
peroxisome
membraneous organelle that serves as an alternative site for oxidation of fatty acids (not mitochondria)
peroxisome
membranous organelle responsible for detoxification of reactive oxygen species
neural crest
meminges of the forebrain and melanocytes are derived from the
less than 10 million per mL
men with sperm counts at this level are considered sterile
down syndrome
mental retardation, epicanthal folds, brushfield spots, simian creases, and decreased alpha fetoprotein are findings consistent with
paraxial, intermediate, and lateral layers
mesoderm gives rise to
lateral plate mesoderm
mesoderm which divides into somatic and splanchic mesoderm
mRNA
messengers, code for proteins
zinc
metal cofactor of carbonic anhydrase, alcohol dehydrogenase, and carboxypeptidase
iron
metal cofactor of cytochrome oxidase, catalase, peroxidase
Manganese
metal cofactor of dipeptidase, superoxide dismutase (SOD)
Cu++
metal cofactor of dopamine beta hydroxylase
selenium
metal cofactor of glutathione peroxidase
Magnesium
metal cofactor of hexokinase, G-6-phosphatase, and enolase
calcium
metal cofactor of lipase
Chloride
metal cofactor of salivary amylase
copper
metal cofactor of tyrosinase, SOD
molybdenum
metal cofactor of xanthine oxidase
vanillylmandelic acid
metanephrine is converted to ________ by MAO
cyanosis
methemoglibinemia is characterized by this easily recognizable sign
suicide inhibition
method of inhibition displayed by sarin
passive conduction
method of signal transduction from motor end plate to excitable membrane areas
Edman's degradation
method to elicit amino acid sequence of a polypeptide
S-adenosyl methionine
methyl group donor for synthesis of epinephrine from norepinephrine
capillaries
microscopic vessels which from a network between arterioles and venules
phosphatidylinositol, phosphatidic acid
minor membrane phospholipids
37
mitochondrial DNA codes for how many genes
electron transport chain
mitochondrial DNA codes for proteins and RNA involved in this mitochondrial function
prozac
model SSRI
Type III Osteogenesis imperfecta
moderate severity form of this disorder; results in multiple fractures at birth, short stature, spinal curvature, and blue sclera
crest
moderately raised, prominent border or ridge of a bone
retinacula
modified deep fascia which forms a fibrous band; holds structures in place in the region of joints
neurotransmitters
molecules that act as chemical signals between nerve cells
chaperones
molecules that facilitate folding of some proteins
MRI
more sensitive and specific, of CT or MRI
phospholipids
most abundant membrane lipids
collagen
most abundant protein; forms 30% of protein mass
sodium and chloride
most chemical neurotransmitters activate channels on the postsynaptic terminal for these ions
helix-turn-helix
most common DNA binding motif
Type I
most common collagen type in humans
glutamate
most common excitatory neurtransmitter of the CNS
ampulla of uterine tube
most common location of ectopic pregnancy
reuptake
most common path for clearance of neurotransmitter from synaptic cleft
thymine dimers
most common type of pyramidine dimer
Type I Osteogenesis imperfecta
most common type of this disorder; causes mild bone fragility, hearing loss, and blue sclera
synovial
most evolved joint type
bilaminar disk
most important feature of week 2 of development
gastrulation
most important feature of week 3 of development
alveoli, arteries, skin, elastic ligaments
most important locations of elastin
beta sheets
most prion proteins exhibit what major secondary structure after misfolding?
Type II Osteogenesis imperfecta
most severe form of this disorder; results in fractures in utero and is lethal in perinatal period
diffusion
movement from an area of high concentration to an area of low concentration
bulk flow
movement of particles similar to turning on a garden hose; respiration and cardiovascular circulation are examples
whartons jelly
mucoid connective tissue of umbelical cord
polyribosome complex
multiple proteins can be simultaneously from the same transcript due to the formation of these structures
mesoderm
muscle is a derivative of what germ layer?
electromyography
muscle testing by electrical stimulation of muscles
simple columnar epithelium
this type of epithelium lines the GI tract and gallbladder; functions in absorption and secretion of digestive enzymes
squamous epithelium
this type of epithelium lines the capillary beds
pseudostratified ciliated columnar
this type of epithelium lines the trachea and the bronchi
competetive
this type of inhibition does not affext vmax
connective tissue
this type of tissue forms the basement membrane and extracellular matrix
1 hour
time for sarin gas to become lethal
primary structure
total number and linear sequence of amino acids in a polypeptide chain
proximal
towards the attachmet
Tetrotoxin (TTX)
toxin found in pufferfish organs
tetra-ethyl-ammonium (TEA)
toxin which blocks potassium activation gates
activators
trans acting factors; can be coded on any chromosome; can work together synergistically to enhance DNA expression
RNA pol II
transcribes all protein encoding genes, as well as snoRNA genes, miRNA gens, siRNA genes, and most snRNA genes
RNA pol III
transcribes all tRNA genes, 5S rRNA gens, some snRNA genes, and other small RNA genes
cosubstrates
transiently associated coenzymes
prions
transmissible spongiform encephalopathies belong to what class of infections agents
IV or INH α1-antitrypsin
treatment of emphysema
glutathione
tripeptide of glutamate, cystine, and glycine
glutathione
tripeptide; essential component required for RBC membrane integrity
myotome
trunk and limb musculature arises from the ___________ layer of the somites
meatus
tube like opening or channel extending within a bone
synovial sheath
tubular sheath that surrounds a tendon
acoustic neuroma
tumor arising in the schwann cells of the vestibulo-cochlear nerve (CN VIII) in the cerebello-pontine angle
sacrococcygeal teratoma
tumor at base of coccyx derived from remnants of the primitive streak; more frequently in females
pheochromocytoma
tumors of adrenal medulla or autonomic nervous system
pheochromocytoma
tumors which secrete high levels of catecholamines
siRNA
turn off gene expression by directing degradation of selective mRNA's and establishing compact chromatin structures
endocrine, exocrine
two general classes of glands
T and R
two hemoglobin conformations
intramembranous and endochondral
two methods by which bone is formed
membranous, non-membranous
two types of cytoplasmic organelles
regular and irregular
two types of dense connective tissue
spatial, temporal
two types of impulse summation
mitosis
type A spermatogonia undergo
primary spermatocytes
type B spermatogonia enter meiosis I and undergo DNA replication to form
translocations, recombinations
types of DNA rearrangements playing a role in gene control
loose, dense, cartilage, bone, blood, adipose
types of connective tissue
isodense, hypodense, hyperdense
types of densities when describing CT
promotors, enhancers, silencers
types of gene control DNA sequences
NMDA, AMPA, Kainite
types of glutamate receptors
microsatellite, minisatellite, satellite
types of noncoding DNA
cartilage, bone, adipose tissue, blood
types of specialized connective tissue
apoptosis
ultimate result of excitotoxicity
helicase
unwinds AT rich sequence at origin to separate DNA strands
carcinoid syndrome
urinary excretion of 5-hydroxyindole acetic acid (5-HIAA) is diagnostic for
intermediate mesoderm
urogenital system, kidneys, and gonads arise from this
Actinomycin D
used as chemotherapy; binds to DNA double helix and prevents unwinding
carboamino Hb
when hemoglobin is carrying CO2, it is called this
4th week
when when heart begins to beat
brain, spinal cord, lungs
where are continuous capillaries found?
above and below the plane
where are the R groups in beta sheet secondary structure
heart and skeletal muscles
where is myoglobin found?
venule
where most absorption takes place (near capillaries)
wall of the yolk sac
where primordial germ cells orignate
respiratory brochus
where squamous epithelium of lower airway begins to appear
MRI
which dye is less likely to cause allergic reaction of CT or MRI
veins
which has the larger lumen, veins or arteries?
arteries
which has thicker walls, veins or arteries?
CT
which is faster of CT and MRI
venous
which is larger, venous or arterial blood volume?
MRI
which is more expensive of CT or MRI
outer
which membrane of the mitochondria is more porous?
partial double bond character prevents free rotation
why is a peptide bond rigid and planar?
epiblast
within this layer, clefts develop and coalesce to form the amniotic cavity
epiphyseal plate
young bone has this layer of cartilage; in adults it is ossified
beta sheets
zigzag pleated pattern of secondary structure with highly extended peptide backbone
basic aa
zinc finger binding regions are rich in this class of amino acids
endothelial cells, basal lamina, very little smooth muscle
structural components of a venule
super-secondary structures
structural motifs forming the core region of the molecule are
collagen, elastin, alpha-keratin
structural proteins
primary chorionic villi
structures formed by the cytotrophoblast which protrude into the syncytiotrophoblast
carriers
structures which can bring larger molecules through a membrane
catalyst
substance which increases the rate of a chemical reaction without being changed by the reaction
Km
substrate concentration when the rate is 1/2 of vmax
heart (H) and muscle (M)
subunit types of LDH
-ase
suffix of most enzymes
cysteine, methionine
sulfur containing amino acids
modified cardiac muscle
the conducting system of the heart consists of what types of cells?
biotin
the conenzyme of pyruvate carboxylase is derived from
microfilaments
the contractile proteins of muscles are composed of this class of filaments
5' to 3'
the direction of DNA replication
epiblast and hypoblast
the embryoblast differentiates into
bilaminar embryonic disk
the epiblast and hypoblast together are called the
cristae
the folds of the inner mitochondrial membrane are called
~25000
the human genome codes for how many genes
trisomy 21
the incidence of this increases with advanced age of the mother
trachea
the layers of tissues in the primary bronchi are the same as the layers in this structure
body
the main portion of a bone
short bone
the metacarpals and metatarsals fall in this general class of bone
9
the number of essential amino acids
RER
the outer nuclear membrane is contiguous with what other membranous organelle?
arteries, veins, pain fibers, lymph vessels
the periosteum contains these fibers and vessels
apoenzyme
the protein part of an enzyme with a non-protein prosthetic group or coenzyme
flat bone
the sternum and cranial bones fall in this general class of bone
cytotrophoblast and syncytiotrophoblast
the trophoblast differentiates into the
ATP, adenosine
purine neurotransmitters
adenine, guanine
purines
inhibits aromatic amino acid decarboxylase in tissues
purpose of carbidopa in treatment of parkinson's disease
prevents alveolar collaps
purpose of surfactant
thymine, cytosine, uracil
pyramidines
phosphorylated
pyruvate dehydrogenase is inactive when it is in its ______________ state
PET
radioactively labelled glucose is tracked by CT; used for diagnosis of malignancies
process
raised area or projection of bone
familial partial lipodystrophy
rare genetic disorder characterized by selective, progressive loss of adipose tissue from various areas of the body; caused by a mutation of Lamin A, part of the nuclear lamina
phenyl isothiocyanate
reagent of edman's degradation method
Frederick Sanger
received a Nobel prize for determination of the primary structure of insulin
rhodopsin, LDL receptors
receptor proteins
neuropeptides
receptors for these neuroactive substances are G-coupled, metabotropic, and slow acting
major groove
recognition helices bind to DNA at this site after "recognizing" a specific DNA sequence
B cells
recombination of DNA to produce different antibodies plays an important role in these immune cells
increases diversity
recombination of antibody genes in B cells accomplishes this purpose
gene control
refers to the ability of eukaryotic organisms to turn genes off or on, or to regulate the amount of expression by particular genes
epinephrine, norepinephrine
regulate carbohydrate and lipid metabolism; mediate "fight or flight" stress response
miRNA
regulate gene expression typically by blocking translation of selected mRNA's
DNA
regulation of gene expression is coded in
2,3-BPG
regulatory molecule affecting O2 binding to Hb
Topoisomerase type II
relaxes supercoiled DNA by cleaving both strands; ATP dependent
Topoisomerase type I
relaxes supercoiled DNA by cleaving one strand; not ATP dependent
epinephrine, norepinephrine
released from adrenal medulla in response to stress
nucleus pulposus
remnants of the notochord present in the __________________ of adults
cortical reaction
renders the secondary oocyte impermeable to sperm after 1 sperm has penetrated the zona pellucida
homologous recombination
repairs double stranded DNA breaks accurately using information from sister chromatids; only after DNA replication
nonhomologous end joining
repairs double stranded DNA breaks; can result in either base deletion or insertion at break site
telomere
repetitive DNA at the end of a chromosome which protects the chromosome from deterioration
telomerases
replenish telomere repeats; contain a stretch of RNA template and a reverse transcriptase
Ascorbic acid, Fe++, O2
required comonents for hydroxylation of pro alpha-chains of collagen
dynein
responsible for bending motion of cilia
kinesin
responsible for straightening motion of cilia
RNA pol I
responsible for transcription of 5.8S, 18S, and 28S rRNA genes
refractory periods
responsible for unidirectional transmission of impulses along axons
-70mV
resting membrane potential of most living cells
-95mV
resting potential if membrane was only permeable to K+
+60mV
resting potential if membrane was only permeable to Na+
transmissible spongiform encephalopathies
result from deposition of insoluble protein aggregates in neural cells after prion infection
dizygotic twins
result from fertilization of two separate secondary oocytes by two separate sperm
conjoined twins
result from incomplete separation of embryblast during formation of monozygotic twins
monozygotic twins
result from splitting of a single embryoblast into two
parkinson's disease
results from degradation of nigrostriatal fibers in the brain
hereditary nonpolyposis colorectal cancer
results from dysfunction of DNA mismatch repair and microsatellite instability
anencephaly
results from failure of closure of the neural tube at the cranial region
spina bifida cystica
results from failure of closure of the neural tube in the lumbosacral region
holoprosencephaly
results from high doses of alcohol during gastrulation; small forebrain with failure to develop into two hemispheres
noncompetetive
reversible inhibition which does not affect Km but does lower vmax
noncompetetive
reversible inhibitors which do not bind at the active site ad do not resemble the substrate
alpha helix
right handed helix coiled around central axis with side chains projecting radially outwards
collagen
rigid structural fiber made up of three alpha polypeptide chains
endometriosis, PID
risk factors for ectopic pregnancy
facet
smooth, flat articular surface of a bone
type B spermatogonia
some type A spermatogonia further differentiate into
sclerotome, myotome, dermatome
somites differentiate into these three layers
3rd-5th week
somites form during these weeks
craniocaudal
somites form in this sequence
intermembranous space
space between outer and inner nuclear membrane
pediatric, pregnant women
special populations in which used of ionizing radiation should be avoided
centromere
specialized area of a chromosome which binds to spindle during mitosis
bone
specialized connective tissue which served a protective function, provides the basis for movement, and also serves as a storage for calcium
olfactory epithelium
specialized epithelium in the roof of the nostrils; allows for sense of smell
sphingomyelin
sphingolipid
introns
splicing of mRNA removes these sequences
AP site
spontaneous loss of nucleotide base leaves this
hydrogen bonds
stabilize the structure of alpha helix
hydroxyproline
stabilizes triple helical structure of collagen by participating in hydrogen bonding
collagen
stacked in cornea to transmit light with minimum scattering
ultrasound
standard method of evaluating fetal growth and development
fixator
steadies proximal part of a limb while movement occurs at a distal part
SER
steroid synthesis occurs in the lumen of this organelle
hCG
stimulates production of progesterone by the corpus luteum until week 8
depolarization
stimulation of Ach nicotinic receptor has this effect on the post-synaptic membrane
cardiac
striated, involuntary muscle
first order kinetics
the velocity of a reaction is directly proportional to the substrate concentration
zero order kinetics
the velocity of the reaction is unaffected by a change in concentration
end of 3rd week
the villous system is ready to supply the embryo with nutrients and oxygen by this time
30ml
there should be this much amniotic fluid at 10 weeks
450ml
there should be this much amniotic fluid at 20 weeks
800-1000ml
there should be this much amniotic fluid at 37 weeks
proline, glycine
these amino acid residues tend to disrupt alpha helix formation
bone, CNS, teeth
these areas lack lymphatic circulation
functional terminal arteries
these arteries have ineffectual anastomoses; blockage of the primary artery results in slow death of tissue
plasma cells
these cells of connective tissue are important in the production of antibodies
fibroblasts
these cells of connective tissue are important in wound healing and the formation of scar tissue
mast cells
these cells of connective tissue secrete histamine
goblet cells
these cells of pseudostratified epithelium secrete mucous
fibroblasts
these cells secrete the collagen fibers of connective tissue
glycolipids
these ceramide based membrane components are minor but essential; exclusive to outer leaflet
fibroblasts
these connective tissue cells secrete collagen and reticular and elastic fibers
III, VII, IX, X
these cranial nerves are part of the parasympathetic nervous system
allosterically regulated enzymes
these enzymes show sigmoid curves on a michaelis-menten plot
DNA Topisomerases
these enzymes unwind and separate supercoiled DNA strands; can also supercoil DNA in prokaryotes
gangliosides
these glycosphingolipids are components of the cell plasma membrane which modulate cell signal transduction events
competetive
these inhibitors are reversible and bind to the active site of an enzyme
primary cartilaginous
these joints begin as cartilage but are later replaced by bone
glycosphingolipids
these membrane components function in cellular ABO blood group antigen recognition
hydroxyproline and hydroxylysine
these modified amino acids are generally in the third position of the repeating sequence of collagen AA chains
Homocysteine, homoserine
these non-protein amino acids are present as intermediates of metabolism
centrioles
these nonmembranous organelles are composed of microtubules and play an important role in separation of genetic material during mitosis/meiosis
microtubules
these nonmembranous organelles self-assemble to form the cytoskeleton
SER, RER, Golgi, Lysosome, peroxisome
these organelles are bound by a single membrane
nucleus, mitochondria
these organelles are bound by double membranes
brain, liver, kidney, spleen, intestines
these organs are supplied by functional terminal arteries
lysine and hydroxylysine
these residues are oxidatively deaminated by a copper containing enzyme to facilitate covalent cross-linking of collagen fibrils
S2-S4
these sacral nerves are part of the parasympathetic nervous system
promotors
these sequences are found upstream of genes, and function in initiation of transcription
L1-L2
these spinal nerves allow flexion and bending at the hip joint
T6-T12
these spinal nerves control movements of the abdominal muscles
T1-T8
these spinal nerves control movements of the chest muscles
S2-S5
these spinal nerves control the anal and bladder sphincters
C3-C5
these spinal nerves enervate the diaphragm
T1-L2
these spinal nerves make up the sympathetic nervous system
type II pneumocytes
these squamous (pseudocuboidal) cells of the alveoli secrete surfactant
type I pneumocytes
these squamous cells of the alveoli do not undergo mitosis
type I pneumocytes
these squamous cells of the alveoli mediate gas exchange
type II pneumocytes
these squamous cells of the alveoli undergo mitosis to replace both pneumocyte cell types
collagen and reticular fibers, blood vessels, nerve fibers
these structures are found in the lamina propria
thyroid, gonads
these structures in pediatric patients are particularly sensitive to ionizing radiation
tropocollagen
these triple helical molecules spontaneously associate to form collagen fibrils in the extracellular space
lysine and hydroxylysine
these two residues in adjacent collagen fibrils form the crosslinks of mature collagen
areolar and lamina propria
these two types of connective tissue make up the connective tissue proper
continuous
these type of capillaries are found in the brain, spinal cord, and lungs
continuous
these types of capillaries form barriers, such as the blood-brain barrier
leak
these types of channels are responsible for resting membrane potential and are present in all cells
myosin
thick filaments of muscle
actin
thin filaments of muscle
pyramidine dimers
this DNA damage occurs as a result of exposure to UV light; can happen between any adjacent pyramidines
HbF
this Hb form has a much higher affinity for oxygen than HbA
RITS
this RNA mediated silencing complex induces formation of heterochormatin
RISC
this RNA mediated silencing complex shuttles mRNA to P-bodies for degradation
lys
this amino acid is important in the formation of desmosine cross-links of elastin
glycine
this amino acid neurotransmitter can be syntheized from CO2 and NH3
lys
this amino acid undergoes oxidative deamination and combines with three other side chains to form a desmosine cross link in elastin
PAM
this antidote can "mop up" sarin before it reaches critical levels of acetylcholinesterase destruction
tertiary structure
this aspect of protein structure refers two the three dimensional conformation assembled from features of secondary structure
multiple myeloma
this bone cancer can cause amyloidosis due to misfolding of light chain of immunoglobulin
sesamoid
this bone type is completely enclosed within a tendon; the patella is an example
methylene blue
this can be used to treat methemoglobinemia caused by deficiency of NADH-MetHb reductase
lymph
this circulatory system is vital in the body's immunologic defense
fibril forming
this class of collagen has high tensile strength
fibril associate
this class of collagen links collagen fibrils to one another and to other components of extracellular matrix
siRNA
this class of small, noncoding RNA binds with argonaute and other proteins to form RITS
microRNA
this class of small, noncoding RNA is associated with RISC complexes, and regulates approximately 1/3 of genes
siRNA
this class of small, noncoding RNA is produced when nuclease Dicer chops up an invading dsRNA
siRNA
this class of small, noncoding RNA must form an exact, complementary match of its ~23 bp sequence with targeted RNA
cartilage
this component of the upper airways disappears entirely at the level of the terminal bronchi
deep fascia
this dense connective tissue is devoid of fat and lies deep to the fatty layer beneath the dermis
epithelial tissue
this diverse tissue can function as a barrier, or mediate absorption, secretion, selective permeability, sensory perception, and excretion
cytosolic
this face of a membrane faces the cytosol, nucleoplasm, or mitochondrial matrix
exoplasmic
this face of a membrane faces the extracellular space or the lumen of an organelle; intermembrane spaces of double membrane organelles
euchromatin
this form of DNA packing is available for replication, transcription, and translation
zwitterionic
this form of amino acid has a charge on both the amino and carboxyl group, but has a net charge of zero
CK-3 or CK-MM
this form of creatinine kinase is found in both skeletal and cardiac muscle
CK-2 or CK-MB
this form of creatinine kinase is found in cardiac muscle
CK-1 or CK-BB
this form of creatinine kinase is found in the brain
Methemoglobin (MetHb)
this form of hemoglobin has a ferric ion
thymus
this gland is often the cause of autoimmune destruction of Ach receptors at the NM junction in young patients
HbA
this hemoglobin composes ~90% of adult hemoglobin
HbA2
this hemoglobin variant comprises 2-5% of total hemoglobin
HbA1C
this hemoglobin variant is conjugated with glucose, and forms 3-9% of adult hemoglobin
lys acetylation
this histone modification always turns on expression of associate genes
lys methylation
this histone modification can turn on or off gene expression; can be done up to 3 times on a single residue
ADP-ribosylation on arg
this histone modification has a role in DNA repair
ubiquitination of lys
this histone modification may have a role in gene expression, but does not, as in some cases, target histones for degradation
phosphorylation of ser and thr
this histone modification plays a role in DNA repair and mitotic chromosome condensation
LH
this hormone stimulates ovulation
decompression sickness or "the bends"
this illness is the result of nitrogen bubbles forming as a person experiences a decrease in pressure; usually seen in divers
ultrasound
this imaging modality produces gray-scale images using sound waves and can be used on abdominal and pelvic structures and the heart
Ca++
this ion enters the presynaptic neuron after an action potential and mediates release of neurotransmitter vesicles
cAMP
this is produced in prokaryotes in low glucose conditions
5' methyl cap
this is the first modification made to eukaryote pre-mRNA, and is added soon after transcription begins
lamina propria
this layer of connective tissue lies below the basement membrane of epithelia
dermis
this layer of dense connective tissue lies deep to the epidermis and contains nerves and vessels for blood and lymph
lamina propria
this layer of epithelial tissue sits beneath the basal lamina
cholesterol
this major membrane component interdigitates between phospholipids in both leaflets; maintains structural integrity of the membrane at temperature extremes
base excision repair
this mechanism repairs base modifications and AP sites
nucleotide excision repair
this mechanism repairs pyramidine dimers and bulky DNA adducts
methylguanosine
this modified RNA forms the "cap" at the 5' end of mRNA
CO
this molecule has an affinity for Hb 220x higher than that of O2
smooth
this muscle type consists of long, spindle shaped cells arranged in bundles
white muscle
this muscle type produces a short contraction per action potential (2-5ms)
red muscle
this muscle type produces sustained contraction from a single action potential (100ms+)
vasoactive intestinal peptide
this neuropeptide acts in the intestine to inhibit smooth muscle contraction; causes dilation of secretory glands
gallbladder
this organ can be visualized with ultrasound, and should be dilated while fasting and shrink after meals
mitochondria
this organelle has a dual membrane, and generates most of the ATP for intracellular processes
mitochondria
this organelle has its own DNA
mitochondria
this organelle is more abundant in muscle and nerve cells in order to meet their higher energy needs
golgi
this organelle is well developed in secretory cells
golgi
this organelle packages propeptide collagen into secretory vesicles
RER
this organelle serves as the site of synthesis for proteins targeted for membranes or for excretion from the cell
eukaryotic
this organism type does not have genes organized in operons
di-isopropyl fluorophosphate
this pesticide inhibits acetylcholinesterase, and was the prototype for poisonous gas, sarin
curare
this poison is a competetive inhibitor of Ach at the neuromuscular junction
parasympathetic
this potion of the PNS increases GI motility, decreases heart rate when at rest
alternative splicing
this process in mRNA results in different proteins being produced by the same gene
gastrulation
this process was disrupted in caudal dygenesis
gastrulation
this process was disrupted in sacrococcygeal teratoma
poly-A binding protein
this protein binds to the 3' end of mature RNA, preventing premature degradation
siRNA
this small, noncoding RNA is effective in silencing ANY gene in cells and animals
microRNA
this small, noncoding RNA is transcribed as introns of mRNA by RNA pol II
microRNA
this small, noncoding RNA must hybridize at least 7 of its ~23 nucleotides to mRNA to achieve silencing
T1
this spinal nerve allows abduction/adduction of the 4th and 5th digits of the hand
C5
this spinal nerve allows bending of the elbow (biceps)
L5
this spinal nerve allows dorsiflextion of the great toe
C8
this spinal nerve allows gripping of the hand
C7
this spinal nerve allows straightening of the elbow (triceps)
C6
this spinal nerve allows wrist movement
L4
this spinal nerve powers dorsiflexion of the foot
L3
this spinal nerve powers leg straightening (quadriceps)
S1
this spinal nerve powers plantar flexion of the foot
muscularis mucosa
this structure of the secondary and tertiary bronchi is increased in the terminal bronchi
thymectomy
this surgical treament for myasthenia gravis is sometimes effective in younger patients
electrophoresis
this technique can be used to separate serum proteins and hemoglobin variants
epithelial tissue
this tissue is derived from all three germ layers
nervous tissue
this tissue type functions in excitability and conductivity
connective tissue
this tissue type serves nutritive, immune, healing, and fat storage roles
muscle tissue
this tissue type serves the function of contractility
alpha latrotoxin
this toxin causes a massive increase in Ach secretion (may increase Ca++ permeability at the terminal)
botulinum
this toxin is taken up at the presynaptic terminals and prevents binding and release of Ach vesicles
hemoglobin
this transport protein has a structure described as a tetramer of dimers
biphosphonates
this treatment for osteogenesis imperfecta inhibits osteoclast activity
glutathione
this tripeptide is a comonent of the cellular antioxidant defense system
acoustic neuroma, schwannoma
this tumor of the brain causes general deficits in balance, and loss of strength and sensation on the left side of the face, and loss of hearing in the left ear
discontinuous
this type of capillary allows for the liver to process substances absorbed during digestion
discontinuous
this type of capillary allows removal of RBC's from circulation by the spleen
fenestrated
this type of capillary has gaps, through which cells and substances can pass
fenestrated
this type of capillary is found in the kidney glomerulus, gallbladder, intestines, and endocrine glands
disontinuous
this type of capillary is found in the liver, spleen, and bone marrow
elastic cartilage
this type of cartilage does not undergo calcification
fibrocartilage
this type of cartilage has fibroblasts
fibrocartilage
this type of cartilage lacks a perichondrium
elastic
this type of cartilage provides flexible support
hyaline
this type of cartilage resists compression
fibrocartilage
this type of cartilage resists deformation under stress
primitive (mesenchyme)
this type of connective tissue is present in embryonic tissue
transitional epithelium
this type of epithelium consists of layers of morphologically different cells
stratified epithelium
this type of epithelium consists of multiple layers and generally serves a protective function
stratified squamous
this type of epithelium forms the lining of the anus and vagina
stratified squamous
this type of epithelium forms the lining of the esophagus
transitional epithelium
this type of epithelium forms the lining of the urinary tract
stratified squamous
this type of epithelium forms the skin, the lining of the pharynx, and the lining of the oral cavity
pseudostratified ciliated columnar
this type of epithelium has cilia, and has goblet cells interspersed throughout
transitional epithelium
this type of epithelium is characterized by its ability to allow stretching
simple squamous epithelium
this type of epithelium lines all blood vessels, the peritoneum, and the glomerulus of the kidney
simple cuboidal epithelium
this type of epithelium lines ducts, the surface of the overies, and the kidney tubules
macrophage
M
osteon
M
white ramus
M
sympathetic ganglion
O
hepatitis
ALT testing is useful in the diagnosis of:
neck
a section of bone between the head and the body
line
a smaller version of a crest, in bone
Phosphorylated
Acetyl-CoA carboxylase is inactive when it is in its ______________ state
glutamic acid, aspartic acid
Acidic amino Acids
sympathetic
"fight or flight"
parasympathetic
"rest and digest"
endothelial cell
F
A
1 letter, Alanine
R
1 letter, Arginine
N
1 letter, Asparagine
D
1 letter, Aspartate
C
1 letter, Cysteine
E
1 letter, Glutamate
Q
1 letter, Glutamine
G
1 letter, Glycine
H
1 letter, Histidine
I
1 letter, Isoleucine
L
1 letter, Leucine
K
1 letter, Lysine
M
1 letter, Methionine
F
1 letter, Phenylalanine
P
1 letter, Proline
S
1 letter, Serine
T
1 letter, Threonine
W
1 letter, Tryptophan
Y
1 letter, Tyrosine
V
1 letter, Valine
blastula
1-16 cell stage of embryonic development
fourth ventricle
F
air blood barier
1. Simple squamous epithelium of alveoli 2. Basal lamina of alveoli 3. Basal lamina of capillary 4. Simple squamous endothelium of capillary these 4 structures form what?
internal elastic membrane
F
large
F
medium-sized
F
satellite
14-500bp repeaets of 20-100kbp in length
minisatellite
15-100bp repeats from 1-5kbp in length
signal peptide
15-60 amino acid sequence at the N-terminus which halts protein synthesis and directs ribosome to the RER
morula
16-32 cell stage of embryonic development
nicotinic Ach receptor
2 acetylcholine bind one each to the alpha subunits of this five-subunit ion channel
glycolysis
2,3-BPG is formed from an intermediate of this intracellular process
short tandem repeats
2-5 bp repeats of less than 150 bp in length
nebulin
F
oblique fissure
F
glucagon
29 aa polypeptide, increases blood glucose levels
glucagon
29 aa polypeptide, secreted by alpha cells of islets of langerhans in the pancreas
desmosine crosslink
3 allysyl and 1 lysyl chains combine to form this in elastin
Ala
3 letter, Alanine
Arg
3 letter, Arginine
Asn
3 letter, Asparagine
Asp
3 letter, Aspartate
Cys
3 letter, Cysteine
Glu
3 letter, Glutamate
Gln
3 letter, Glutamine
Gly
3 letter, Glycine
His
3 letter, Histidine
Ile
3 letter, Isoleucine
Leu
3 letter, Leucine
Lys
3 letter, Lysine
Met
3 letter, Methionine
Phe
3 letter, Phenylalanine
Pro
3 letter, Proline
Ser
3 letter, Serine
Thr
3 letter, Threonine
Trp
3 letter, Tryptophan
Tyr
3 letter, Tyrosine
Val
3 letter, Valine
proofreading
3' to 5' exonuclease activity of DNA polymerases is mostly associated with this function
Primary, Secondary, Tertiary, Quaternary
4 levels of protein structure
ventral rootlets
F
viseral layer of serous pericardium
F
insulin
51 aa polypeptide, decreases blood glucose levels
insulin
51 aa polypeptide, secreted by beta cells of the islets of langerhans in the pancreas
volkmann's canal
F
transcription control, RNA processing control, RNA transport and localization control, translation control, mRNA degradation control, protein activity control
6 stages at which gene expression can be regulated
Riboflavin (B2)
FAD is derived from
Lateral ventricle
A
Manubrium
A
Osteonal artery
A
Z line
A
aorta
A
dorsal horn
A
elastic fiber
A
endocardium
A
nasal cavity
A
nucleus
A
olfactory vesicle
A
tunica adventitia
A
multiple sclerosis
A chronic disease of the central nervous system marked by damage to the myelin sheath. Plaques occur in the brain and spinal cord causing tremor, weakness, incoordination, paresthesia, and disturbances in vision and speech
ser, tyr
AA residues commonly phosphorylated/dephosphorylated in enzyme regulation pathways
L
All amino acids are found in this chiral configuration
Glucogenic
All amino acids except lysine and leucine share this property
Isoleucine, Phenylalanine, tryptophan, tyrosine
Amino acids that are both Glucogenic and ketogenic
Ketogenic
Amino acids that can be converted to acetoacetate or one of its precursors are said to be...
Glucogenic
Amino acids that can be converted to pyruvate or one of the other intermediates of the citric acid cycle are said to be...
smooth muscle of terminal and respiratory bronchi
Asthma and COPD affect these structures of the lower respiratory tract
It is dissociated (carboxylate ion)
At physiologic pH (7.4), what happens to the carboxyl group of an amino acid?
It is protonated
At physiologic pH(7.4), what happens to the amino group of an amino acid?
Folic acid
FH-4 is derived from
Riboflavin (B2)
FMN is derived from
SA node
B
smooth muscle cells
J
collagen fibers
B
fibroblast
B
intraventricular foramen (of Monro)
B
junctional complex
B
myocardium
B
nasopharynx
B
sarcolemma
B
superior vena cava
B
tropomysin
B
tunica media
B
ventral horn
B
Lysine, Arginine, Histidine
Basic Amino Acids
A Band
C
spinal nerve
J
cilia
C
collagen
C
epicardium
C
interstitial lamellae
C
lateral horn
C
oropharynx
C
right atrium
C
right main bronchus
C
terminal cisterna of sarcoplasmic reticulum
C
third ventricle
C
tunica intima
C
neural crest
C cells of the thyroid and conotruncal septum of the heart are derived from the
3-6 hours
CK-MB begins to rise _____________ hours after MI
12-24 hours
CK-MB peaks _____________ hours after MI
2-3 days
CK-MB returns to nomal _________ days after MI
Pantothenic acid (B5)
CoA is derived from
B12
Cobalamin is derived from
metaplasia
Conversion of normal cells into less differentiated types in response to chronic stress/ injury
AV node
D
H Band
D
T tubule
D
tropomodulin
J
left ventricle
M
central canal
D
endothelial cells
D
horizontal fissure
D
inner circumferential lamellae
D
larynx
D
median aperture (foramen of Magendie)
D
pericardium
D
plasma cells
D
supporting (sustentacular) cell
D
histones
DNA associated proteins
semiconservative
DNA replication uses a parent strand as a template and is thus __________
enhancers
DNA sequences that increase the rate of transcription; bind activator proteins
silencers
DNA sequences that prevent transcription of a gene; bind repressor proteins
1.65
DNA wraps around histone octamer this many times (in absence of H1)
more than 6.5%
Diabetic A1C
Lateral aperture (foramen of Luschka)
E
M line
E
adipose tissue
E
axon
E
basal lamina
E
bundle of His, AV bundle
E
dorsal rootlets
E
endosteum
E
mast cell
E
mitochondria
E
right atrium
E
trachea
E
Purkinje fibers
F
T tubule
F
basal cell
F
diaphragm
F
"diad"
G
alveoli
G
cerebral aqueduct (of Sylvius)
G
dorsal root
G
elastic lamella
G
fibroblast
G
inferior vena cava
G
lamellae of bone
G
lymphocytes
G
olfactory (bowman's) gland
G
parietal layer of serious pericardium
G
reticular and fine collagen fibrils
G
right bundle branch
G
titin
G
unmyelinated nerves
G
F actin
G actin monomers combine to form these filaments
glutamate
GABA is synthesized from ____________ by glutamate decarboxylase (PLP conenzyme)
benzodiazepines, barbituates
GABA receptor agonists
anxiety
GABA receptor agonists can be used to treat
alpha ketoglutarate to glutamate
GABA-glutamate transaminase converts __________ to ___________ while breaking GABA down to succinate semialdehyde
M line
H
Z Line
H
adipose cell
H
alveolar sacs
H
diaphragm/liver
H
elastic lamellae
H
fibroblast
H
fibrous pericardium
H
left bundle branch
H
olfactory cell
H
osteonal endosteum
H
smooth muscle cells
H
unmyelinated nerves
H
ventral root
H
phosphorylated
HMG-CoA reductase is inactive when it is in its ______________ state
1480
How many amino acids in CFTR protein?
191
How many amino acids in Growth Hormone?
153
How many amino acids in Myoglobin?
141
How many amino acids in the alpha chain of hemoglobin?
146
How many amino acids in the beta chain of hemoglobin
serine, threonine, tyrosine
Hydroxylic amino acids
H band
I
alpha-actinin
I
alveolar ducts
I
aortic arch
I
basal lamina
I
blood vessel
I
bundles of smooth muscle
I
dorsal root ganglion
I
eosinophil
I
external elastic membrane
I
haversian canal
I
macrophage
I
pericardial cavity
I
Total CK
In MI and skeletal muscle disorders, this is elevated
vmax
In michaelis-menten kinetics, the reaction rate when enzymes are saturated with substrate
amino and carboxyl groups
In peptide bond formation, these two groups of adjacent amino acids are combined
Mitochondria
Intracellular location of TCA cycle, FA oxidation, and pyruvate oxidation
Sarcoplasmic reticulum
J
collagen fibers
J
collagen fibrils
J
elastic fibers
J
macrophage
J
microvilli
J
osteocyte and lacuna
J
pericardium
J
pulmonary trunk
J
respiratory broncioles
J
Z line
K
bronchioles
K
collagen fibers
K
collagen fibrils
K
dorsal ramus
K
left main bronchus
K
myelinated nerve
K
myomesin
K
periosteum
K
right ventricle
K
Leucine, Isoleusine, phenylalanine, tryptophan, tyrosine, lysine
Ketogenic amino acids
C protein
L
T tubule
L
bronchi
L
bundle of smooth muscles
L
elastic
L
left atrium
L
muscular
L
outer circumferential lamella
L
right atrium
L
ventral ramus
L
heart, RBC's
LDH1-HHHH locations
kidney, RBC, heart
LDH2-HHHM locations
brain, kidney
LDH3-HHMM locations
spleen, lungs, kidney
LDH4-HMMM locations
liver, skeletal muscle
LDH5-MMMM locations
serotonin
LSD and ecstasy target receptors in this neurotransmitter system
E7
Location of distal His in hb
denaturation
Loss of secondary, tertiary, quaternary structure of a protein is called
actin
M
aorta
M
elastic fibers
M
fibroblast
M
nitrates
Methemoglobinemia can be caused by administration of this class of antianginal drugs
20
Number of Amino Acids coded for by DNA
300
Number of Amino Acids occurring in nature
blood vessel
O
1-3 hours
Myoglobin rises _________ hours after MI
alpha-actinin
N
gray ramus
N
myelinated nerve
N
oblique fissure
N
unmyelinated nerves
N
anserine
N-methyl carnosine, found in muscle and brain; can reduce fatigue
Niacin (B3)
NAD+ is derived from
Niacin (B3)
NADP+ is derived from
Ca++
NMDA receptors are ___________ channels
4-5.6%
Nomal A1C
Glycine, Alanine, Valine, Methionine, Leucine, Isoleucine, Proline, Phenylalanine, Tryptophan
Nonpolar amino acids
collagen fibrils
O
diaphragm
O
Glycine
Only amino acid that is not optically active
Proline
Only amino acid with a secondary amino group on the alpha carbon
left costophrenic angle
P
smooth muscle cells
P
unmyelinated nerves
P
Pyridoxine (B6)
PLP is derived from
Serine, Threonine, Asparagine, Glutamine, Cysteine, Tyrosine
Polar, Uncharged amino acids
5.7-6.5%
Prediabetic A1C
cleavage of C and N terminal non-helical portions
Procollagen undergoes this process extracellularly to become tropocollagen
fibroblast
Q
gastric bubble
Q
ribozymes
RNA enzymes
ribozymes
RNA molecules with catalytic activity
DNA breaks
Radiation and cosmic rays often cause this type of DNA damage
S-adenosyl homocysteine
S-adenosyl methionine is converted to ____________ when it donates its methyl group
buffer
a solution that resists change in pH following the addition of acid or base
Glycine, Alanine
Straight chain amino acids
Thiamine (B1)
TPP is derived from
Lipoic acid
The conenzyme of PDH complex is derived from this vitamin
histones
These DNA associated proteins can be methylated, phosphorylated, or acetylated to regulate gene expression
hydrophobic, hydrogen bonding, disulfide bidges, elecrostatic
These forces serve to stabilize the three-dimensional arrangement of a folded protein
Triiodothyronine (T3), Thyroxine (T4)
These non-protein amino acids are hormones functioning in metabolic regulation
Ornithine, Citrulline, Arginosuccinic Acid
These non-protein amino acids are intermediates in the synthesis of urea
HbF
This hemoglobin, prominent during gestation, comprises less than 2% of adult hemoglobin
Lamin B
This lamin is phosphorylated during prophase
Gamma-amino butyric acid (GABA)
This non-protein amino acid functions as a neurotransmitter in some cells
Taurine
This non-protein amino acid is a component of bile acids
S-adenosyl methionine
This non-protein amino acid serves as a methyl group donor
parasympathetic
This portion of the PNS has ganglia close to the target organs
Prothrombin
This posttranslationally modified protein contains gamma-carboxyglutamic acid and is required for blood clotting
D
This rarely naturally occurring chiral amino acid configuration is found in antibiotics and some bacterial cell walls
denatures them, making them digestible
What function does HCl of gastric juice perform on dietary proteins?
absolute specificity
When an enzyme acts only on a single substrate, the enzyme is said to have
at the N terminus
Where does numbering of a poly-peptide begin, by convention?
schwannoma
a benign, usually slow-growing tumor that develops from the balance and hearing nerves supplying the inner ear. The tumor comes from an overproduction of Schwann cells
angle
a corner, composed of bone
plasticity
ability of nearby neurons to take over the functions of damaged neurons by making new connections to replace lost ones
ectopic pregnancy
abnormal uterine bleeding, unilateral pelvic pain, increased hCG in unknown pregnancy or low hCG for gestational age, first trimester bleeding are signs of
superior/cranial
above, anatomically
lymphedema
accumulation of interstitial fluid due to failure or obstruction of lymph system
neostigmine, pyrostigmine
acetylcholine esterase inhibitors used in the treatment of myasthenia gravis
antagonist
acts in opposition to prime mover muscle
7-methylguanosine
added to 5'end of pre-mRNA to form cap
plasmid
additional, closed, circular DNA fragments; can carry genes for antibiotic resistance and are able to be transferred between bacteria
fast, portable, small radiation dose, triage for surgery
advantages of pain radiographs
ovum
after fertilization, the secondary oocyte completes meiosis II, forming a mature
zygote
after fusion of the male and female pronucleus, a ________ is formed
progesterone
after ovulation, granulosa lutein cells of the corpus luteum secrete
sinus
air-filled cavity within a bone
SER
alcohol is detoxified in the membrane of this organelle
cytoplasm
all components inside of a cell membrane
mother
all mitochondrial DNA is inherited from this parent
protein
all nonmembranous organelles are composed of this substance
epithelial tissues
all of this type of tissue, which lines all body surfaces, is avascular
fifth month
all primary oocytes are formed by the _____________ month of fetal development
cyanide
allosteric inhibitor of chytochrome oxidase of electron transport chain
Fluoride
allosteric inhibitor of enolase of glycolysis
Lead
allosteric inhibitor of ferrochelatase and ALA dehydratase of heme synthesis
anastomoses
allow for continued blood supply if the primary vessel is blocked
alternative splicing
allows eukaryotes to form multiple different proteins from the same gene
crossover
allows exchange of maternal and paternal genetic material during meiosis I
subcutaneous tissue
also called superficial fascia, this loose areolar tissue has abundant adipose storage and lies deep to the dermis
vasopressin
alternate name for antidiuretic hormone
basal lamina
always lies underneath epithelial tissue
acetylcholine, dopamine, epinephrine, norepinephrine, serotinin, histamine
amine neurotransmitters
Glutamate, aspartate, glycine, GABA
amino acid neurotransmitters
IU
amount of enzyme that catalyzes conversion of 1 μmole of substrate to product per minute
20-100 million/mL
amount of sperm produced by fertile males
copy number
amplification of a gene in the DNA sequence increases this, and ultimately results in greater expression of the gene
parasympathetic
anabolic portion of the PNS
alpha fetoprotein
anmiocentesis is performed to measure
palmar
anterior surface of hand, in the anatomical position
Aspirin, NSAIDS
anti-inflammatory drugs that irreversibly inhibit cyclooxygenase
novobiocin
antibiotic acting on bacterial type II topoisomerases; blocks binding of ATP to gyrase
rifampin
antibiotic; binds to beta subunit of prokaryotic RNA polymerase
nalidixic acid, ciprofloxacin, levofloxacin (quinolones)
antibiotics acting on bacterial type II topoisomerases; prevent rejoining of DNA after breaks
10 micron
diameter of intermediate filaments
20 micron
diameter of microtubules
5 micron
diameter of thin filaments (microfilaments)
osmosis
diffusion of water through a semi-permeable membrane
vanillylmandelic acid
dihydroxymandelic acid is converted to ____________ by COMT
carnosine
dipeptide of alanine and histidine that is present in the muscle and brain
aspartame
dipeptide of aspartate and phenylalanine; used as artificial sweetener
carnosine
dipeptide with antioxidant effect that is used in anti-aging therapy
barbituates
directly stimulate GABA receptors in the absence of GABA
radiation, low contrast, 2 dimensional
disadvantages of plain radiographs
sinusoids
discontinuous capillaries are also called
scurvy
disease caused by deficiency of Vitamin C
gout
disease of the joints caused by buildup of uric acid in the tissues
oxygen
distal His associates to this
frontal/coronal
divides body into anterior/posterior
sagittal
divides body into left and right
transverse
divides body into upper and lower
no
does cartilage have blood vessels?
voluntary movements
dopamine in the basal gangia controls this
emotional responses, memory
dopamine in the limbic system controls this
bromocriptine
dopamine receptor agonist used in treatment of parkinson's disease
neural crest
dorsal root ganglia are derived from the
thoracic duct
drains the lower extremities and lower trunk, left upper trunk and left arm
right lymphatic duct
drains the right arm and upper right trunk
dynein
drive intracellular transport toward the minus end of microtubules
kinesin
drive intracellular transport toward the plus end of microtubules
hydrogen bonding
driving force of secondary structure folding
methylation and snoRNA
driving forces of rRNA maturation
clomiphene citrate
drug used for treatment of anovulation in women
anode (+)
during protein electrophoresis, which pole do proteins migrate toward?
secondary oocyte
during the ovarian cycle, a primary oocyte completes meiosis I and becomes a
secondary chorionic villi
during the third week, extrembryonic somatopleuric mesoderm cells penetrate the primary villi, forming
proteasome
dysfunction of this organelle is suspected when proteins are stored and accumulate within the cell
leaflet
each half of the phospholipid bilayer is called a
feedforward activation
earlier pathway intermediate activates enzyme
neuroectoderm, neural crest
ectoderm gives rise to
margin
edge of a flat bone
favors T form
effect of 2,3-BPG on hemoglobin
blocks sodium activation gate
effect of Tetrotoxin
slow repolarization
effect of blocking potassium activation gates
1/1000
efficiency of endogenous DNA repair mechanisms means only this fraction of base changes remain as permanent mutations
gly, ala, pro, and val
elastin is rich in these amino acid residues
3rd-4th
embryonic folding happens during these weeks
epiphysis
end part of a long bone, usually has a larger diameter than the shaft
epiblast
extraembryonic mesoderm is derived from the
ptosis
eye drooping
proline
facilitates helical structure of collagen alpha chain by inducing kinks
O2, CO2, pH, 2,3-BPG
factors affecting loading and unloading of oxygen to hemoglobin
temperature, pH, substrate concentration
factors affecting the rate of an enzyme-catalyzed reaction
repressors
factors which shut down gene expression; often work with HDAC
mad cow disease
famous infectious prion disease
villous chorion
fetal portion of the placenta
Type IX, XII
fibril-associated collagen types
Type I, Type II, Type III
fibril-forming collagen types
syndesmosis
fibrous connection between radius and ulna
gomphosis
fibrous connection that holds teeth to bones
raphe
fibrous or tendinous band; pterymandibular, pharyngeal, and scrotal are examples
appendicitis
finding that the wall of the appendix appears thickened on ultrasound supports this diagnosis
tyrosine-> dihydroxyphenylalanine (DOPA) by tyrosine hydroxylase
first step of dopamine synthesis
minus end
fixed end of microtubule assemble (close to centrosome)
aponeuroses
flat fibrous sheets or expanded broad tendons; connect muscle to bone
belly
fleshy, contractile portion of musle
CK-2 or CK-MB
following MI, this creatinine kinase is elevated in the blood stream
hydrogen bonds
force that holds together the triple helix of collagen
hydroxyapatite
form of calcium phosphate in the bones
H2A, H2B, H3, H4
form the "bead" around which a nucleosome is wound
rRNA
form the basic structure of the ribosome and catalyze protein synthesis
microtubules
form the structural framework for cilia and flagella
amnion
formed at week 2 from the epiblast
blastocyst
formed when fluid secreted within the morula forms a cavity
sclerotome
forms cartilage and bone, derivative of somite
elastic cartilage
forms cartilages of larynx: epiglottis, corniculate, and cuneiform cartilages
hyaline cartilage
forms costal cartilages, cartilages of nasal cavity, larynx
hyaline cartilage
forms fetal skeletal tissue, epiphyseal plates, articular surface of synovial joints
collagen
forms gel in extracellular matrix and vitreous humor of eye
fibrocartilage
forms insertion of tendons
fibrocartilage
forms intervertebral discs, symphysis pubis
fibrocartilage
forms meniscus and triangular cartilage complex of wrist
myotome
forms muscle; derivative of somite
elastic cartilage
forms pinna of external ear, external acoustic meatus, eustachian tube
hyaline cartilage
forms rings of trachea and plates in bronchi
paraxial mesoderm
forms somites
foramen
round hole of bone through which blood vessels, nerves, or ligaments pass
tubercle
round nodule or warty outgrowth of bone
condyle
rounded bump or large rounded prominence of a bone
head
rounded projection of bone that forms part of a joint
tendon
rounded, fibrous, noncontractile muscle portion that connects to the bone
median
sagittal plane passing through nose, mouth, navel
calcium phosphate
salt contributing to hardness of bone
ipsalateral
same side
neural crest
schwann and glial cells are derived from the
neural crest
schwann cells are derived from what embryonic feature?
ligase
seals nicks in DNA backbone; joins Okazaki fragments
DOPA->dopamine by aromatic amino acid decarboxylase
second step of dopamine synthesis
fertilization
secondary oocytes complete meiosis II at _____________
spermatids
secondary spermatocytes complete meiosis II to form 4
golgi tendon organ
senses changes in muscle tension. It is a proprioceptive sensory receptor organ that is at the origins and insertion of skeletal muscle fibers into the tendons of skeletal muscle
AAUAAA
sequence which signals the end of a gene to RNA pol II
hallucinogens
serotinin agonists are often ______________
enterochromaffin cells
serotonin producing tumors can arise from the ___________________ of the GI tract, causing carcinoid syndrom
operon
several genes controlled by same promotor in prokaryotes
diaphysis
shaft of a long bone
fossa
shallow depression, in bone
edrophonium (tensilon)
short acting inhibitor of acetylcholinesterase
simple cuboidal epithelium
single layer of epithelial cells in which height of each cell is approximately equal to the width
simple columnar epithelium
single layer of epithelial cells in which the height of each cell is greater than the width
simple squamous epithelium
single layer of flattened epithelial cells
cardiovascular defects
single umbilical artery indicates 20% chance of these
beneath stratified squamous epithelium
site if type VII collagen
lumen of RER
site of Y position proline and lysine hydroxylation
peroxisome
site of breakdown of uric acid
hydroxylyxine
site of glycosylation of pro alpha-chains of collagen
rER
site of histone synthesis
nucleus
site of mRNA processing, capping, polyadenylation
nucleolus
site of rRNA synthesis
basement membrane
site of type IV collagen
cartilage
site of type IX collagen
lys and arg peptide bonds
sites of hydrolysis by enzyme trypsin
Skin, bone, tendon, blood vessels, cornea
sites of type I collagen
cartilage, intervertebral disc, vitreous body
sites of type II collagen
blood vessels, fetal skin
sites of type III collagen
tendon, ligaments, other tissues
sites of type XII collagen
ectoderm
skin is derived from this germ layer
neuropeptides
small peptides shown to influence neural function
arteriole
smallest arteries
chorionic cavity
the conceptus is suspended by the connecting stalk within the
fibrous
sutures, syndesmosis, and gomphosis are examples of this type of joint
neural crest
sympathetic chain and preaortic ganglia are derived from the
increasing Ca++ permeability during slow repolarization
sympathetic stimulation increases heart rate by
norepinephrine
sympathetic synapses use neurotransmitter ____________ at the end organ synaptic terminal
flushing, increased HR, abdominal pain, diarrhea
symptoms of carcinoid syndrome
ionotropic
synaptic response is fast, doesn't last
metabotropic
synaptic response is slow, lasts longer, uses second messengers
achondroplasia, marfans syndrome
syndromes associated with advanced paternal age
condyloid
synovial joint composed of a convex surface articulating with a concave surface; permits movement in two axes
hinge
synovial joint composed of one convex and one curved surface; permits movement in only one axis
ball and socket
synovial joint comprised of a globular head and a cup-shaped socket; permits movement in many axes
saddle
synovial joint comprised of two concavo-convex surfaces; permits movement in two axes
pivot
synovial joint with central bony pivot surrounded by osseoligamentous ring; permits twisting movement in one axis
plane
synovial joint with flat surface; permits gliding/sliding movements
primase
synthesizes a short RNA primer for DNA replication
mifepristone/misoprostol
taken in conjunction, 96% effective at terminating pregnancy
amniotic bands
tears in the amnion which can encircle parts of the fetus; causes amputation, deformities
AGGGTT
telomere sequence in humans
minisatellite
telomeres fall in the ___________ category of noncoding DNA
rho dependent
termination which depends on formation of a hairpin structure to slow transcription
golgi
the "post office" of the cell
Valine, Methionine, Leucine, Isoleucine, Phenylalanine, Tryptophan, Threonine, Histidine, Lysine
the Essential amino acids
permeability
the ability of a substance to move across a membrane
neural crest
the adrenal medulla is derived from the
quaternary structure
the association of two or more polypeptide chains into a single functional protein is referred to as what?
black widow
the bite of this spider causes tetany in adults, but is not usualy lethal except in children and small animals
irregular bone
the bones of the face and the spine fall in this general class of bone
dense regular connective tissue
the collagen fibers of this connective tissue are numerous and arranged in orderly, parallel bundles
irregular dense
the collagen fibers of this connective tissue are numerous and randomly oriented
scaRNA
used to modify snoRNA and snRNA
snoRNA
used to process and chemically modify rRNA's
xray
uses photons to acquire images at a single point in time
chondroblasts and chondrocytes
usual cells of cartilage
Myoclonic Epilepsy with ragged red fibers
usually caused by mutation of mitochondrial DNA, this condition causes weakness, muscle spasms, and spasticity
notch
v shaped depression in the margin or edge of a flat area of bone
valve failure
varicosities of medium veins are caused by this
sclerotome
vertebrae and ribs arise from the ___________ layer of the somites
0.54nm
vertical length of each turn in an alpha helix
RNA viruses
viruses which use reverse transcriptases to synthesize DNA
folic acid
vitamin which prevents neural tube defects
skeletal
voluntary, striated muscle type
splanchic mesoderm
wall of digestive and respiratory tracts (not epithelium), visceral serosa, heart, and blood vessels are derived from this layer
atrophy
wasting of muscle tissue
blastocyst
week 1 of development, fetus is called
8
week when fetus resembles baby
10
week when genitalia are expressed
4
week when hear has 4 chambers
4
week when heart begins to beat
4
week when limb buds form
3-8
weeks when organogenesis occurs
continuous, fenestrated, discontinuous
what are the three types of capillaries?
proteins
what forms the junctions between epithelial cells?
breaks up into cartilaginous plates because more flexibility is needed due to lung movement
what happens to the cartilage as you descend from primary bronchi into secondary and tertiary bronchi? Why?
charge/mass ratio
what is the basis of separation observed in protein electrophoresis?
trans
what is the configuration of a peptide bond?
PrPsc is misfolded, PrPc is natively occurring protein (usually alpha helix)
what is the difference between PrPc and PrPsc?
high mutation rates
what is the expected outcome when an RNA virus uses a polymerase lacking proofreading activity?
keeps trachea and primary bronchus patent
what is the function of the cartilage of the trachea and primary bronchus?
within one unit of pKa
what is the ideal range of a buffer
c-shaped
what is the shape of the cartilage of the trachea?
98
what percent of the human genome is noncoding?
lacuna
what structures do the chondrocytes of cartilage sit in
proline, glycine
what two amino acids are frequently associated with bends and turns?
2
when H1 is present, DNA wraps around histone octamer this many times
stereospecificity
when an enzyme acts on only L or D isomers, it is said to have
isomeric specificity
when an enzyme acts only on either cis or trans bonds, it is said to have
group specificity
when an enzyme can act on a few related substrates, it is said to have
heteroptropic
when an enzyme effoector is different from the its substrate it displays ___________ regulation
homotropic
when an enzyme is regulated by its substrate it displays ______________ regulation
carboxy Hb
when hemoglobin is carrying CO, it is called this