Pharmacology Exam 4 Quizzes

Choose the drug which is a H2-receptor antagonist. Omeprazole Zegerid OTC Lansoprazole Ranitidine

Ranitidine

You developed an adrenergic agonist to be used as a vasodilator. Which of the following characteristics does your drug have? It activates the relaxation of smooth muscle in blood vessels It activates beta 2 receptors in smooth muscle It activates phosphorylation of MLC kinase All of the above a and b

all of the above

Stimulation of which receptors causes vasoconstriction? Beta-1 receptors Beta-2 receptors Alpha receptors None of the above

alpha receptors

H1 histamine receptor is present in _____________. Endothelial cells Smooth muscles Gastric mucosa 1 and 2 All of the above

1 and 2

Metoprolol decreases oxygen demand because _________. It decreases phase 4 depolarization in SA node cells It decreases the activity of calcium channels in SA node cells It increases contractility of cardiomyocytes All of the above 1 and 2

1 and 2

Which statement is CORRECT concerning ephedrine? Ephedrine is transported into secretory vesicles by VMAT Ephedrine is taken up by the neuron using NET Ephedrine increases NE release by activating exocytosis Ephedrine binds to adrenergic receptors 1 and 2 None of the above

1 and 2

Which statement is CORRECT concerning the postganglionic neurons in the adrenergic system? They are long neurons They release NE and E They are short neurons 1 and 2 2 and 3

1 and 2

What statement is CORRECT about the β3 receptor? It couples to the Gq family of G proteins increasing calcium It activates adenylate cyclase, producing an increase of cAMP levels It is coupled to the Gs family of G proteins 1 and 2 2 and 3

2 and 3

Which effect IS NOT caused by a selective beta-1 antagonist in the cardiovascular system? A decrease in intracellular calcium in heart cells A decrease in blood pressure An increase in O2 demand Bradycardia

An increase in O2 demand

A new drug was introduced into the marker that decreases blood pressure due to a decrease in the level of NE at the synapse. This new drug is an__________ and has specificity for _________. Adrenergic antagonist; alpha-2 postsynaptic receptor Adrenergic agonist; beta-2 receptor Adrenergic agonists; alpha-2 presynaptic receptor Adrenergic antagonists; alpha-1 postsynaptic receptor None of the above

Adrenergic agonists; alpha-2 presynaptic receptor

Which adrenergic receptor is an excitatory receptor? β2R β1R α1R All of the above None of the above

All of the above

Which effect is produce by beta-2-receptor agonist? They cause a decrease in blood pressure They cause epinephrine release They can cause muscle tremor All of the above None of the above

All of the above

Which statement is CORRECT regarding the effects of Beta-1 receptor agonists on AV node cells? They increase calcium current They increase the AV rate of conduction They increase phase 4 depolarization All of the above 1 and 2

All of the above

The __________presynaptic receptors decrease the release of Norepinephrine. Beta 2 Alpha 2 Beta 1 Alpha 1

Alpha 2

Which adrenergic antagonists are used for the management of pheochromocytoma? Selective beta2-receptor antagonists Nonselective beta-receptor antagonists Indirect-acting adrenergic antagonists Alpha receptor antagonists

Alpha receptor antagonists

Norepinephrine increases intracellular calcium levels by acting on___________. Alpha-1 receptor Alpha-2 receptor Beta-1 receptor Beta-2 receptor

Alpha-1 receptor

The binding of an adrenergic agonist to __________ in the radial muscle in the eye will produce_______________. Alpha-1 receptor; Pupil constriction (miosis) Beta-2 receptor; Accommodation for close vision Alpha-1 receptor; Pupil dilation (mydriasis) Alpha-1 receptor; Pupil dilation and far vision Beta-2 receptor; Pupil constriction and loss of accommodation

Alpha-1 receptor; Pupil dilation (mydriasis)

__________ is the predominant receptor in the heart. Alpha 1 Alpha 2 Beta 1 Beta 2

Beta 1

What adrenergic receptor is the main receptor present in the heart? Beta 1 receptor Alpha 1 receptor Beta 2 receptor Alpha 2 receptor

Beta 1 receptor

Norepinephrine can act directly on these receptors to increase heart rate. Beta-1 receptors Beta-2 receptors Alpha-1 receptors Alpha-2 receptors

Beta-1 receptors

You develop an agonist that increases blood pressure by increasing the levels of NE at the synapse. To what receptor your drugs will bind to? Beta-1 receptor Beta-2 receptor Alpha-2 presynaptic receptor Alpha-1 receptor Beta-2 presynaptic receptor

Beta-2 presynaptic receptor

A drug was developed to delay premature labor. The drugs has specificity for _____. Beta-2 receptors in the uterus Alpha-2 receptors in the uterus Alpha-1 receptors in the uterus Beta-1 receptors in the uterus

Beta-2 receptors in the uterus

Which agent could significantly impair the ability to drive a car? Ergotamine Fexofenadine Diphenhydramine Ranitidine

Diphenhydramine

Which effect IS NOT produce by an alpha-receptor antagonists? They cause a fall in peripheral resistance and blood pressure They cause epinephrine reversal Bronchoconstriction They may cause postural hypotension and reflex tachycardia

Bronchoconstriction

Which antihistaminic drug is used as prophylaxis for motion sickness? Fexofenadine Loratadine Cyclizine Cetirizine

Cyclizine

Which enzyme forms a methylderivative of NE and E during catecholamine metabolism? MAO enzyme Dopamine beta-monooxygenase COMT enzyme DOPA decarboxylase

COMT enzyme

You develop a drug that activates alpha-2 presynaptic receptor. This drug will___________. Increase the release of NE at the synapse Decrease the release of NE at the synapse Not change NE levels at the synapse None of the above

Decrease the release of NE at the synapse

Phenylephrine is applied to the nasal mucosa because it ________ by ________. Decreases mucus secretion; blocking histamine receptors Increases mucus secretion; inducing vasodilation Decreases mucus secretion; inducing vasoconstriction Increases blood pressure; blocking beta-2 receptors

Decreases mucus secretion; inducing vasoconstriction

Which H1 antihistaminic has high anti-cholinergic activity? Fexofenadine Diphenhydramine Loratadine Cyclizine

Diphenhydramine

Which enzyme catalyzes the conversion of norepinephrine to epinephrine? Dopamine beta-monooxygenase Phenylethanolamine N-methyltransferase Tyrosine Hydroxylase Dopa decarboxylase

Dopamine beta-monooxygenase

What is the primary negative feedback signal for gastric phase secretion? Somatostatin Gastrin Acetylcholine All of the above None of the above

Either Somatostatin or Acetylcholine

___________ is an indirect-acting sympathomimetic drug. Epinephrine Phenylephrine Ephedrine Isoproterenol

Ephedrine

Alpha 1 selective antagonist has a significant effect on blood pressure. True False

False

An advantage of using diphenhydramine HCl (Benadryl) in the treatment of allergic reactions is its insignificant antimuscarinic activity. True False

False

An antihistaminic is very effective at treating an asthma attack. True False

False

Collateral ganglia innervate organs located above the diaphragm. True False

False

Fexofenadine is a first generation antihistaminic that produces drowsiness as a side effect. True False

False

Postganglionic neurons that innervate the thorax synapse with preganglionic neurons at a collateral ganglion. True False

False

A highway truck drive has rhinorrhea, watery eyes and sneezing. Which drug will you prescribe to him? Diphenylhydramine (Benadryl) Cyclizine (Marezin) Fexofenadine (Allegra) None of the above

Fexofenadine (Allegra)

A 24 year-old patient is diagnosed with allergic rhinitis. In addition to a decongestant what other drug could you recommend to counteract the effects of histamine without producing CNS side effect? Cyclizine Chlorpehniramine Diphenhydramine Fexofexadine

Fexofexadine

Which effect is not block by an H1 receptor antagonist? Vasoconstriction Gastric acid secretion Increased permeability Bronchoconstriction

Gastric acid secretion

Nizatidine (Axid) inhibits gastric acid secretion indirectly stimulated by ______ and _______. Gastrin; acetylcholine Histamine; gastrin Prostaglandins; somatostatin None of the above

Gastrin; acetylcholine

Which of the following histamine receptor increases the release of gastric acid? H1 receptor H2 receptor H3 receptor H4 receptor

H2 receptor

Alpha adrenergic receptor subtypes are associated with all of the following tissues, EXCEPT____. Heart Blood vessels Prostate Pupillary dilator muscle

Heart

Which enzyme is essential for the conversion of histidine to histamine? Histidine amylase Histidine hydrolase Histidine decarboxylase Histidine phosphorylase

Histidine decarboxylase

Which statement is CORRECT concerning somatostatin? Inhibits histamine release by gastrin Activates histamine release by gastrin Inhibits the H+ pump Activates the H+ secretion

Inhibits histamine release by gastrin

Desipramine increases the levels of NE at the synapses because_________. Increases the synthesis of NE by activating tyrosine hydroxylase Inhibits MAO enzyme decreasing the metabolism of NE Inhibits the NET transporter decreasing the re-uptake of NE None of the above

Inhibits the NET transporter decreasing the re-uptake of NE

Reserpine abolishes the effects produced by amphetamine because________. It increases the metabolism of catecholamines It inhibits the uptake of amphetamine It depletes norepinephrine at the nerve terminal It increases the transport of norepinephrine into neurons

It depletes norepinephrine at the nerve terminal

Which statement is INCORRECT concerning Dobutamine? It has a short duration of action It produces vasoconstriction It increases heart rate It increases contractility

It has a short duration of action

Which statement is INCORRECT concerning Carvedilol (Coreg)? It is a beta1-selective antagonist It produces a decrease in heart rate It produces vasodilation by blocking alpha-1 receptors It can produce bronchoconstriction

It is a beta1-selective antagonist

Which statement is INCORRECT concerning histamine? It is a bronchodilator Large concentration may cause a fall in blood pressure Large concentration may cause a fall in blood volume Its release contributes to the symptoms of anaphylaxis

It is a bronchodilator

Tums is effective to treat intermittent heartburn because__________. It activates H2 histamine receptor It neutralizes gastric acid producing MgCl2, CaCl2, CO2 and water It neutralizes gastric acid producing NaCl, CO2 and water It neutralizes gastric acid producing CaCl2, CO2, and water

It neutralizes gastric acid producing CaCl2, CO2, and water

What effect would a histamine H2 antagonist have on the release of gastric acid? It would increase secretion It would decrease secretion It would have no effect It would stop secretion completely

It would decrease secretion

Which of the following beta receptor antagonists is preferable in patients with asthma? Propranolol Metoprolol Nadolol Timolol

Metoprolol

Gastric acid secretion is under the indirect control of ________. Histamine Acetylcholine Gastrin 1 and 2 2 and 3 All of the above

NOT: All of the above, 1 and 2, Gastrin

All the following tissues are innervated by both cholinergic and sympathetic system, EXCEPT________. Ventricles in the heart Smooth muscle in the bladder Smooth muscle in the blood vessels Iris dilator or radial muscle 3 and 4

NOT: Smooth muscle in the blood vessels, Ventricles in the heart, Iris dilator or radial muscle

_____ is a proton pump inhibitor. Pirenzepine Ranitidine Omeprazole Trimethaphan

Omeprazole

Which is a common side effect of a selective alpha-1 antagonists? Orthostatic hypotension Mydriasis Hypertension Bradycardia

Orthostatic hypotension

___________is an alfa-receptor antagonist that irreversible blocks the receptor and has a long duration of action. Phentolamine Phenoxybenzamine Ergotamine Prazosin

Phenoxybenzamine

Which drug is a nonselective alpha receptor antagonist? Prazosin Phentolamine Metoprolol Reserpine

Phentolamine

In the adrenergic system, acetylcholine is released by__________. Preganglionic neuron Postganglionic neuron Both Pre and Postganglionic neurons None of the above

Preganglionic neuron

NE increases blood pressure by producing vasoconstriction. What statement is CORRECT concerning the effect of reserpine in the vascular system? Reserpine blocks alpha-1 receptors in blood vessels decreasing blood pressure Reserpine decreases the storage of NE depleting NE at the synapse Reserpine decreases blood pressure by decreasing NE release at the synapse 1 and 2 2 and 3 1, 2 and 3

Reserpine decreases the storage of NE depleting NE at the synapse Reserpine decreases blood pressure by decreasing NE release at the synapse

The termination of NE effects at the synapse is mainly due to_________. Metabolism Diffusion of NE away from synapse Hydrolysis at the synapse Reuptake into presynaptic nerve terminal

Reuptake into presynaptic nerve terminal

Sensitization of mast cells requires___________. The release of histamine from the mast cells The binding of IgE to receptors on mast cells The binding of allergen to mast cells 1 and 2 2 and 3

The binding of IgE to receptors on mast cells

Which statement is INCORRECT concerning the effects produced at higher doses of histamine in the vascular system? Vasodilation is produced through the activation of H2 receptors There is an increase in intracellular cAMP There is a slow onset of vasodilation due to the activation of H1 receptors The activation of H2 receptors promotes the activation of protein kinase A

There is a slow onset of vasodilation due to the activation of H1 receptors

Which statement is CORRECT regarding the effects of Beta-1 receptor blockers on the heart? They increase heart rate They decrease contractility They increase rate of conduction of AV node They increase phase 4 depolarization

They decrease contractility

Acetylcholine can produces an increase of the release of NE. True False

True

Antacids are weak bases that react with gastric hydrochloric acid to form salt and water. True False

True

Common side effect of first-generation H1 antagonists is sedation. True False

True

____________catalyzes the rate limiting step in the synthesis of catecholamines. Dopa decarboxylase Phenylethanolamine N-methyltransferase Tyrosine hydroxylase Dopamine beta-monooxygenase

Tyrosine hydroxylase

Terbutaline is used to treat asthma because________. It activates Beta-2-adrenergic receptors in bronchial smooth muscle It produces bronchodilation It activates Beta-1 receptors in bronchial smooth muscle a and b b and c

a and b

You developed an agonist to be used in an emergency situation as a short term treatment for heart failure. Which of the following characteristics does your drug have? It increases force of cardiac contraction It activates Beta-1 receptors It decreases heart rate a and b b and c

a and b

A Beta-1 adrenergic agonist increases heart rate because it decreases phase 4 by increasing calcium current in SA Node cells. True False

false

A new adrenergic agonist has been introduced into the market to treat urinary incontinence. This drug also produces vasodilation as a side effect. The side effect is due to the activation of Beta-2 receptors and PLC in blood vessels, decreasing the level of intracellular calcium in smooth muscle cells. True False

false

Alpha-1 antagonists are used to treat hypertension because they completely reverse the vasoconstriction produced by epinephrine. True False

false

NE and E are metabolized at the synapse by MAO and COMT enzymes producing vanillylmandelic acid. True False

false

Release of epinephrine from chromaffin cells in the adrenal medulla is produce following the release of ACh from postganglionic neuron synapsing with the cells. True False

false

Silodosin (Raplafo) is used to produce a decrease in blood pressure because it block alpha-1 receptors. True False

false

Activation of alpha-1 receptor in the radial muscle in the eye promotes___________. Pupil dilation Far vision Pupil dilation and far vision Pupil constriction

pupil dilation

What is the main clinical use for β1 antagonists? Treatment of glaucoma treatment of hypertension Treatment of asthma Treatment of pain

treatment of hypertension

Cocaine increases heart rate because it increases the levels of NE at the synapse. True False

true

In anaphylaxis, you use epinephrine instead of NE because it stimulates Beta-2 receptors at a relatively lower dose. True False

true

MAO inhibitors potentiate the effect of amphetamine. True False

true

The antidepressant Desipramine inhibits the norepinephrine transporter, increasing the effect of norepinephrine at the synapse by interfering with the metabolism of NE. True False

true

The main regulatory pathway of gastric acid secretion could be inhibited by blocking CCK receptors on ECL cells. True False

true

Epinephrine decreases intracellular cAMP levels by acting on____________. α1 receptor α2 receptor beta1 receptor beta2 receptor

α2 receptor