Psy330 exam 2

dopamine drugs

Cocaine (indirect agonist - blocks reuptake), Amphetamine (indirect agonist - blocks reuptake and enhances release), Haloperidol/Haldol (competitive antagonist - D2 receptor), Chlorpromazine/Thorazine (competitive antagonist - D2 receptor), Clozapine/Clozaril (competitive antagonist - D4 receptor)

dopamine receptors

D1, D2, D3, D4, D5

Serotonin Associated Disorders

Depression

indirect agonist

Indirect-binding agonists enhance the neurotransmitter actions by stimulating neurotransmitters' release, increasing the emissions. An example of an indirect-binding agonist is cocaine. Enhances actions of the actual neurotransmitter. Drug to stop addiction such as stopping heroine.

Serotonin drugs

LSD (direct agonist), Ecstasy (indirect agonist - blocks reuptake and enhances release), Fluoxetine/Prozac (indirect agonist - blocks reuptake), Sertraline/Zoloft (indirect agonist - blocks reuptake), Paroxetine/Paxil (indirect agonist - blocks reuptake)

Glutamate Main Functions

Major Excitatory Neurotransmitter, Learning and Memory

Serotonin major functions

Mood, Sleep Regulation

Glutamate Receptors

NMDA, AMPA, Kinate, mGluR'

acetylcholine receptors

Nicotinic ACh receptor, Muscarinic ACh receptor

Norepinephrine and Epinephrine drugs

Propanalol/Inderal (competitive antagonist - β1, β2 receptor), Clonidine (direct agonist α2 receptor)

dopamine disorders

Schizophrenia, Drug Abuse, Parkinson's Disease, OCD

Norepinephrine and Epinephrine Main Functions

Sympathetic Nervous System Activation

direct agonist

The first acts just like a neurotransmitter, binding directly to the receptor site - this direct bind allows the recipient to experience the effects of the drug as if they were released directly into the brain. Examples of direct-binding agonist drugs include dopamine, apomorphine, and nicotine. Mimic's actions of neurotransmitter. Heroine, drug giving you these effects.

agonist

a chemical or a drug that binds to receptors in the brain and causes a reaction. Has a biological Effect. Agonist drugs mimic the effects of neurotransmitters naturally found in the human brain.

acetylcholine associated disorders

alzheimer's disease

non-competitive antagonist

binds to an allosteric (non-agonist) site on the receptor to prevent activation of the receptor. it changes/alters shape of binding site and prevents it to interact. Refer to as deadbolt. prevents action from happening because the activation is never taken on and it prevents it from interacting. surrounds it to mis-form the shape so it cannot bind

competitive antagonist

binds to the same site as the agonist but does not activate it, thus blocks the agonist's action. wrong key in lock but still fits. prevention action from happening because of blocking. attaches and blocks

antagonists

chemical or drug that binds to receptors in the brain and prevents an agonist from having a reaction. No biological effect.

acetylcholine drugs

icotine (direct agonist - Nicotinic Receptor), Rivastigmine/Exelon (indirect agonist - prevents metabolism), Donepazil/Aricept (indirect agonist - prevents metabolism), Botox (noncompetitive antagonist - prevents release)

acetylcholine major functions

memory, neuromuscular functions

pharmacokinetics

process that drugs are absorbed, transported, metabolized, and then eliminated. How drugs more through your system and then how they are removed.

pharmacodynamics

the actual effects of drugs/how it affects your behavior.

dopamine main functions

thought, pleasure, motor function

Norepinephrine and Epinephrine Receptors

α1, α2, β1, β2