Quiz 12

Etylene glycol poisoning causes a. ethanol-like symptoms due to acetone as a metabolic product b. renal tubular damage due to oxalic acid as a metabolic product c. severe acidosis and blindness to formaldehyde and formic acid as metabolic products d. liver damage due to acetaldehyde as a metabolic product

b. renal tubular damage due to oxalic acid as a metabolic product

A drug has a half-life of 6 hours. If a dose is given every 6 hours, a steady-state drug level would usually be achieved in: a. 3-5 hours b. 10-12 hours c. 24-42 hours d. 48-50 hours

c. 24-42 hours

How many doses of a therapeutic drug are usually required to reach a steady serum concentration? a. 2 b. 3 c. 6 d. 10

c. 6

Peak values for digoxin are not measured until ___ hours after administration. a. 3 b. 5 c. 8 d. 10

c. 8

Which tumor marker is associated with hepatocellular carcinoma? a. carcinoembryonic antigen b. CA-125 c. AFP d. PSA

c. AFP

The drug procainamide is prescribed to treat cardiac arrhythmia. What biologically active liver metabolite of procainamide is often measured simultaneously? a. phenobarbitol b. quinidine c. N-acetyl procainamide (NAPA) d. lidocaine

c. N-acetyl procainamide (NAPA)

In addition to carcinoma of the prostate, elevated prostate-specific antigen (PSA) can occur due to: a. aspirin therapy b. exogenous steroid use c. benign prostatic hyperplasia d. statin therapy (cholesterol lowering drug)

c. benign prostatic hyperplasia

Cocaine is metabolized to a. hydrocodone b. codeine c. benzoylecgonine d. carbamazepine

c. benzoylecgonine

A carbonate salt used to control manic-depressive disorders is: a. digoxin b. acetaminophen c. lithium d. phenytoin

c. lithium

Testing for the diagnosis of lead poisoning should include: a. erythrocyte protoporphyrin (EPP) b. urine delta-aminoevulinic acid c. whole blood lead d. zinc protoporphyrin (ZPP)

c. whole blood lead

Which of the following statements most correctly describes the utility of clinical laboratory assays for tumor markers? a. Tumor markers are useful to screen asymptomatic patients for tumors. b. Tumor markers are highly specific. c. Tumor markers indicate the likelihood of an individual developing a tumor. d. Tumor markers are useful in tracking the efficacy of treatment.

d. Tumor markers are useful in tracking the efficacy of treatment.

Cocaine is metabolized to: a. carbamazepine b. codeine c. hydrocodone d. benzoylecgonine

d. benzoylecgonine

Carcinoembryonic antigen (CEA) is most likely to be produced in a malignancy involving the: a. brain b. testes c. bone d. colon

d. colon

What is the primary product of methanol metabolism by the ADH and ALDH system? a. formaldehyde b. oxalic acid c. acetaldehyde d. formic acid

d. formic acid

N-acetylprocainamide a. is not an active metabolite of procainamide b. is not ordinarily assayed along with procainamide c. is not reported with the procainamide result d. is an active metabolite of procainamide

d. is an active metabolite of procainamide

A 3-year-old child was evaluated for abdominal pain and anorexia by a physician. A CBC revealed a hemoglobin of 9.8 g/dL (98 g/L) and basophilic stippling of the RBCs. The doctor should order further tests to check for poisoning from: a. arsenic b. iron c. mercury d. lead

d. lead

Lithium therapy is widely used in the treatment of: a. hypertension b. hyperactivity c. aggression d. manic-depressive (bipolar) disorder

d. manic-depressive (bipolar) disorder

The metabolite 11-nor-tetrahydrocannabinol-9-COOH can be detected by immunoassay 3-5 days after a single use of: a. methamphetamine b. cocaine c. benzodiazepine d. marijuana

d. marijuana

Cancer antigen 125 (CA 125) is a tumor marker associated with: a. breast carcinoma b. colon cancer c. lung cancer d. ovarian and endometrial carcinoma

d. ovarian and endometrial carcinoma

An antiepileptic (or anticonvulsant) used to control seizure disorders is: a. digoxin b. acetaminophen c. lithium d. phenytoin

d. phenytoin

A drug that relaxes the smooth muscles of the bronchial passages is: a. acetaminophen b. lithium c. phenytoin d. theophylline

d. theophylline

Clinical assays for tumor markers are most important for: a. screening for the presence of cancer b. monitoring the course of a known cancer c. confirming the absence of disease d. identifying patients at risk for cancer

b. monitoring the course of a known cancer

A salicylate level is performed to detect toxicity caused by ingestion of excess: a. acetaminophen b. aspirin c. ibuprofen d. pseudoephedrine

b. aspirin

A serum PSA is used for all of the following except a. detecting recurrence b. diagnosis c. monitoring response d. estimating prostate size

b. diagnosis

Detection of which of the following substances is most useful to monitor the course of a patient with testicular cancer? a. alpha-fetoprotein b. carcinoembryonic antigen c. prolactin d. testosterone

a. alpha-fetoprotein

A widely used marker for colorectal cancer is a. carcinoembryonic antigen b. CA-125 c. AFP d. PSA

a. carcinoembryonic antigen

A cardiac glycoside that is used in the treatment of congenital heart failure and arrhythmias by increasing the force and velocity of myocardial contraction is: a. digoxin b. acetaminophen c. lithium d. phenytoin

a. digoxin

Increased concentrations of alpha-fetoprotein (AFP) in adults are most characteristically associated with: a. hepatocellular carcinoma b. alcoholic cirrhosis c. chronic active hepatitis d. multiple myeloma

a. hepatocellular carcinoma

Which of the following is useful in the detection and management of carcinoma of the prostate? a. total prostate-specific antigen b. prostatic acid phosphatase c. human chorionic gonadotropin d. alpha-fetoprotein

a. total prostate-specific antigen

Ovarian and endometrial cancer is detected and monitored by a. carcinoembryonic antigen b. CA-125 c. AFP d. hCG

b. CA-125