Understanding Chapter 16: Blood

1. The primary site for red blood cell production: 2. The primary site for the destruction of old red blood cells: 3. The site of excess iron storage and metabolism of bilirubin from red blood cell breakdown: 4. A protein carrier needed for the transport of iron throughout the plasma: 5. Must be ingested from our diet in order to produce new red blood cells 6. A byproduct of the breakdown of old red blood cells that is removed from the body either through the renal system or as bile:

1. bone marrow 2. spleen 3. liver 4. transferrin 5. iron 6. bilirubin

A patient takes a drug that decreases liver production of albumin. Which would you expect?

Decreased osmotic pressure and increased water in interstitial fluid

Both blood transfusions and drugs that mimic the effects of erythropoietin (EPO) are used to increase hematocrit. Which of the following statements is true?

EPO increases red blood cell count by stimulating red blood cell synthesis, while blood transfusions add red blood cells from an exogenous source.

Hemostasis has three major steps. The first is vasoconstriction and the final step is coagulation. What occurs between these two steps?

Formation of a platelet plug

What is a hematocrit and why would testing this value provide a means for determining blood doping?

It is the percentage of red blood cells in a centrifuged sample of blood. Because blood doping is an artificial way of increasing red blood cell count.

How does blood doping enhance athletic performance?

It provides more oxygen for metabolism.

What is the stimulus for synthesis and release of erythropoietin?

Low oxygen tissues

Which organelles are present in mature erythrocytes?

None

Drag the labels onto the diagram to identify the components of blood.

Page 512 Fig 16.1

Drag the labels onto the diagram to identify steps that occur during a coagulation response.

Page 524 Fig 16.8 Page 526 Fig 16.10

Which organ is most responsible for the breakdown of old erythrocytes?

Spleen

Drag and drop each of the following terms, labeling the adult hemoglobin molecule correctly. Labels can be used more than once.

iron on the porphyrin ring

The binding of platelets to collagen can stimulate a positive feedback loop that results in more platelets adhering to collagen. Which signal causes the positive feedback loop?

platelet-activating factor (PAF)

Which of the following components are arranged together to compose 97.5% of adult hemoglobin?

β-chain, α-chain, porphyrin ring, iron