LabCEHemo

The decreased serum iron levels seen in anemia of chronic disease (also referred to as anemia of chronic infection or inflammation) is caused by which of the following? Increased total iron binding capacity (TIBC) Decreased serum ferritin Increased erythropoietin Decreased iron released from macrophages

decrease iron relaeased from macrophages

Which of the following leukemias can be excluded as a possible diagnosis if Auer rods are seen in blasts on the peripheral blood smear? Acute myelomonocytic leukemia Acute lymphoblastic leukemia Acute myeloid leukemia without maturation Acute promyelocytic leukemia

Acute lymphoblastic leukemia

Which of the following coagulation test results would be prolonged in a deficiency of Factor X? Please select the single best answer PT only aPTT only Both PT and aPTT Neither PT nor aPTT

Both Pt and aPTT

On this alkaline electrophoresis gel, which patient most likely has alpha thalassemia? Lanes 5 and 6 represent controls.

Patient 3

The cells which release von Willebrand's Factor (vWF) are:

Platelets and endothelial cells

Which of the following is responsible for inhibiting the tissue plasminogen activator Antithrombin Tissue Factor Pathway Inhibitor Thrombin Protein C

Protein C

All of the following can cause erroneously decreased automated platelet counts EXCEPT? Please select the single best answer Platelet clumping Platelet satellitosis Clotting WBC fragmentation

WBC fragmentation

Which test result will be normal in a patient with dysfibrinogenemia? Please select the single best answer Thrombin time Reptilase test Clot based - fibrinogen assay Immunologic fibrinogen level

immunologic fibrinogen level

Which red cell morphological classification is characteristic of megaloblastic anemia? Normocytic Microcytic Hypochromic Macrocytic

macrocytic

A laboratory professional will perform a mixing study to differentiate between a factor deficiency and a coagulation inhibitor as the cause of a prolonged prothrombin time (PT) or activated partial thromboplastin time (aPTT) test result. The mixing study should be performed within what time frame following collection of the specimen? 4 hours 8 hours 24 hours 48 hours

4 hours

Which of the following is least likely to interfere with the measurement of hemoglobin? Please select the single best answer Icteric plasma Lipemia Cold agglutinin Leukocytosis

cold agglutinin

Which of the following is MOST responsible for increasing the erythrocyte sedimentation rate (ESR)? Please select the single best answer Fibrinogen Albumin Alpha-2-globulins and beta-globulins Gamma-globulin

fibrinogen

All of the following are coagulation assays that employ low-reagent phospholipids and thus are sensitive to Lupus Anticoagulant (LA) (Antiphospholipid Antibodies) EXCEPT: Please select the single best answer Kaolin clotting time (KCT) Dilute Russell viper venom time (DRVVT) Activated partial thromboplastin time (aPTT) Dilute partial thromboplastin time (DTT)

aPTT

What are the white blood cell inclusions that are indicated by the arrows in this image

aurer rods

An SDS-agarose gel electrophoresis for determining different multimer sizes of von Willebrand factor (vWF) is performed on a group of patients. Which of the following would indicate a patient who does not have von Willebrand Disease (vWD)? A column which has two heavy-staining bands and two light-staining bands (meaning a large quantity of two different multimers, and a small quantity of two other multimers). A column which has 11 heavy-staining bands. A column which has 10 light-staining bands. A column which has three light-staining bands.

A column which has 11 heavy-staining bands

All helper cells are T cells. Consequently, in a normal lymphocyte population, it is reasonable to expect all CD4-positive cells to also be positive for which of the following CD markers? Please select the single best answer CD3 CD20 CD33 CD41 and CD42

CD3

Regarding hemoglobin synthesis, which of the following constitutes the alpha globin chain coding? Please select the single best answer Two gene loci; one each on chromosome 11. Four gene loci; two each on chromosome 11 .Two gene loci; one each on chromosome 16. Four gene loci; two each on chromosome 16.

Four gene loci; two each on chromosome 16

In which disorder may a mild anemia be present even with an increased red blood cell (RBC) count and normal adult hemoglobin electrophoresis? Alpha thalassemia silent carrier Alpha thalassemia minor Alpha thalassemia intermedia Alpha thalassemia major

Alpha thalassemia minor

A 72-year-old patient has a routine check-up and CBC. The CBC shows a high absolute neutrophil count of 28,000/µl, with slightly elevated bands, a few immature myeloid cells, and slight toxic granulation. Upon further examination of the patient, hepatomegaly and splenomegaly are noted. Because of the splenomegaly and the lack of obvious infection, a bone marrow exam is performed which shows hypercellularity of the granulocytes. Molecular testing yields a CSF3R mutation. The most likely diagnosis is: Pelger-Huet anomaly Chronic Myelogenous Leukemia (CML) Chronic Neutrophilic Leukemia (CNL) Primary Myelofibrosis (PMF)

Chronic Neutrophilic leukemia

All of the following tests are useful in the diagnosis of heparin induced thrombocytopenia (HIT) EXCEPT: Please select the single best answer Platelet aggregometry Enzyme-linked immunosorbant assay (ELISA) Carbon 14 serotonin washed platelet release assay Dilute partial thromboplastin time (DTT)

Dilute partial thromboplastin DTT

The light blue-gray inclusions observed in the cytoplasm of many of the bands and segmented neutrophils of a burn patient are most likely?

Dohle bodies

All of the cells listed below function as a phagocyte, EXCEPT? Please select the single best answer Neutrophil Eosinophil Monocyte Macrophage

Eosinophil

Which of the following factors is Vitamin K-dependent? Please select the single best answer Factor I Factor VIII Factor IX Factor XI

Factor IX

Which of the following assays is commonly used to confirm the diagnosis of Activated Protein C resistance? Factor V Leiden Mutation AssayAntithrombin Activity AssayAntithrombin Antigen AssayAnticardiolipin Antibody Immunoassay

Factor V leiden mutation

ll of the following disorders would affect the results of a Prothrombin time (PT) EXCEPT? Please select the single best answer Factor VIII deficiency Coumadin Vit.K deficiency Alcoholic cirrhosis

Factor VIII

Which of the following options best describes how hemophilia A differs from hemophilia B? The clinical presentation is drastically different. Hemophilia A is an inherited disorder and hemophilia B is an acquired disorder. Factor VIII is deficient in hemophilia A and factor IX is deficient in hemophilia B. Hemophilia A is a disorder of secondary hemostasis and hemophilia B is a disorder of primary hemostasis.

Factor VIII in A and IX in B

All of the following tests will be abnormal in a patient with Stuart-Prower Factor deficiency EXCEPT?

Fibrinogen

The image on the right is a representative field from a peripheral blood smear. What characteristics would describe the red cell distribution curve that you would expect to see? Please select the single best answer Histogram with two peaks Histogram with a shift to the left Histogram that is wider than normal Histogram with a shift to the right

Histogram with a shift to the left...compare to lymphocyte Lymphocyte and RBC approx same size

A medical laboratory scientist working in Hematology was performing Myeloperoxidase staining on a suspected AML case. They found positive reactions of the segmented neutrophils. What would be the next step? Please select the single best answer -Report result, patient is confirmed for AML -Report result and perform Sudan Black B and Esterase stains to further confirm AML -Inaccurate result, Myeloperoxdase stain confirms ALL and not AML -Inaccurate result, only blast cells are to be examined for reaction

Inaccurate result, only blast cells are to be examine for rxn

he granules of Basophil contain which of the following? Please select the single best answer Antihistamine IgE The contents of helminth digestion Initiators of allergic inflammation

Initiators of allergic inflammation

All of the following are sites of active hematopoiesis in the adult EXCEPT: Skull Ribs Live rPelvis

Liver

Blood samples for complete blood counts are collected on morning rounds and stored in a rack in the phlebotomist's basket. When the phlebotomist delivers the samples to your workstation, the cells and plasma in the samples have separated. As a result, one of the samples has lipemic plasma. Which of the following parameters may be affected by the lipemia? RDW MCV MCHC None of the parameters would be affected.

MCHC

he structure indicated by the arrow in this image, along with giant platelets (also present in the image), is characteristic of which of the following conditions? Chediak-Higashi anomaly Alder-Reilly anomaly May-Hegglin anomaly Infectious Mononucleosis

May-Hegglin anomaly

Calculate the mean corpuscular hemoglobin content (MCHC) when Hgb = 15 g/dL (150 g/L), RBC count = 4.50 x 106/µL (4.50 x 1012/L), and Hct = 47% (0.47).

The formula for the MCHC is (Hemoglobin (g/dL) / Hematocrit (%)) x 10

A patient has the following hematology test results. Classify the anemia present by choosing one of the options below. Hgb = 8.1 g/dL Hct = 31% RBC = 4.0 x 1012/L Please select the single best answer Macrocytic, hypochromic Normocytic, normochromic Microcytic, normochromi Microcytic, hypochromic

Microcytic, hypochromic

What type of lymphocyte appears as a large cell with abundant cytoplasm and a few azurophilic granules?

Natural killer lymphocyte

Hematocrit is: Please select the single best answer Percentage of blood made up of serum Concentration of serum X 100 Percentage of blood made up of red blood cells Concentration of red cells X 100

Percentage of blood made up of RBC

A patient has a history of repeated spontaneous abortion. Coagulation studies reveal an elevated APTT, normal PT, normal platelet function, and normal thrombin time. Schistocytes were seen on the peripheral blood smear. Which test should be performed to determine if the patient has lupus anticoagulant? Factor VIII assay Mixing studies with factor-deficient plasmas Antinuclear antibody test Platelet neutralization test

Platelet neutralization test is the confirmatory test that can be used to determine if a patient has circulating lupus antibody

Which of the following is currently considered to be a good test for screening persons for hereditary hemochromatosis (HH) due to its sensitivity and specificity for iron overload? Transferrin saturation Liver biopsy Phlebotomy Serum iron alone

Transferrin Saturation

Normal adult CSF may have 0-5 white blood cells (WBCs)/µL. Which of the following cell types account for 60-100% of these WBCs? Please select the single best answer Neutrophils Lymphocytes Monocytes Eosinophils

lymphocytes

All of the following activities are associated with platelets EXCEPT: Please select the single best answer Aggregation Adhesion Lysis Release of granules

lysis

When comparing normal cells, the nucleus of a small lymphocyte is about the same size as a? Please select the single best answer Normal erythrocyte Small monocyte Large platelet Band neutrophi

normal erythrocyte

What is the correct order of erythrocyte maturaton in the bone marrow? (beginning from the most immature) Please select the single best answer -Polychromatophilic normoblast? basophilic normoblast? polychromatophilic erythrocyte? orthochromic normoblast? pronormoblast -Orthochromic normoblast? basophilic normoblast? polychromatophilic normoblast? polychromatophilic erythrocyte? pronormoblast -Pronormoblast? basophilic normoblast? polychromatophilic normoblast? orthochromic normoblast? polychromatophilic erythrocyte -Pronormoblast? basophilic normoblast? polychromatophilic erythrocyte? orthochromic normoblast? polychromatophilic normoblast

number 3

A monoclonal B-cell population (Kappa or Lambda predominant) with expression of CD19, CD20, CD23, and co-expression of CD5 is consistent with which of the following? Please select the single best answer A normal B cell Chronic lymphocytic leukemia Mantle cell lymphoma A mature T cell

Chronic lymphocytic leukemia

Which of the following conditions is associated with the defective erythrocytes that are indicated by the arrows in this image? G6PD deficiency Microangiopathic hemolytic anemia Abetalipoproteinemia Beta thalassemia

G6PD deficiency

The arrangement of erythrocytes on this peripheral blood smear can be associated with each of the following conditions EXCEPT: Please select the single best answer Multiple myeloma Cold agglutinin disorders Chronic inflammatory disorders Lymphoplasmacytic lymphoma

cold agglutinin disorders