Chapter 11 Malignant Disorders of white blood cells
Which type of leukemia primarily affects children?
Acute Lymphoid Leukemia Ages 3 to 5
Manifestations of acute lymphoblastic leukemia include
Anemia Leukocytosis Thrombocytopenia
A diagnostic laboratory finding in myeloma is
Bence Jones proteins in the urine
Myeloma may invade
Bone, lymph nodes, liver, spleen, and kidneys
Which leukemia demonstrates the presence of the Philadelphia chromosome
Chronic myeloid leukemia
A pt is diagnosed with stage IIA Hodgkin disease. The pt's clinical stage was most likely determined by
Patient history CT scan Physical exam
Treatment for stage III non Hodgkin lymphoma
Radiation Chemotherapy Tissue specific therapies such as monoclonal antibodies Bone marrow transplants
Autologous stem cell transplantation is a procedure in which
Stem cells are harvested from the pt and then returned to the same pt
ALL (acute lymphocytic leukemia) is manifested by the malignant
Transformation of B cells and some T cells
Acute Myeloid Leukemia (AML) is associated with
Transformation of myeloid stem cell
Chronic Lymphocytic Leukemia (CLL) is associated
With T cell transformation
The major cause of death from leukemic disease is
infection
Which viruses have been implicated as cancer causing agents
Epstein-Barr - Hodgkin disease, Burkitt lymphoma Human T cell leukemia - adult T cell lymphoma and leukemia HIV - B cell lymphomas
Burkitt lymphoma is closely associated with
Epstein-Barr virus
Symptoms experienced with chronic myeloid leukemia
Fatigue Weight loss Abdominal discomfort - due to enlarged spleen Bleeding High granulocyte count Sweats
A patient is diagnosed with hairy cell leukemia. The pt's lab results would most likely indicate a decrease in
Granulocytes Platelets Red blood cells
Thrombocytopenia can produce a life threatening
Hemorrhage
A diagnosis of plasma cell myeloma is confirmed by the presence of
Hypercalcemia Compression fracture Generalized bone demineralization
The most serious complication of chemotherapy is
Infection
ALL (acute lymphocytic leukemia)
Is highly curable in the pediatric population with 85% survival rate
Chronic myeloid leukemia
Is manifested by splenomegaly
Allogeneic bone marrow transplant from a suitable donor
Is the only curative treatment for CMI
What is the correct definition of complete remission
Less than 5% blasts in marrow and normal CBC values maintained for at least 4 weeks
Chronic Lymphoid Leukemia (CLL) is a disease that affects
Lymphoid tissues and bone marrow
Renal insufficiency is a common complication of
Myeloma due to hyperproteinemia, Bence Jones protein Hypercalcemia Hyperuricemia
Compression of the spinal cord is one of the two most serious oncology emergencies associated with
Non-Hodgkin lymphoma
Clinical findings for Acute Lymphoid Leukemia
Pain in long bones Infection Fever Bruising * onset is abrupt and may begin when a child refuses to walk or begins to exhibit loss of appetite, fatigue, and abd pain
The Philadelphia chromosome is a balanced chromosome translocation that forms a new gene called
bcr-abl Chromosome 9 and 22
