MediaLab ASCP BoC Practice Exam - Fall 2022
Serum proteins can be separated by cellulose acetate electrophoresis into how many basic fractions: Please select the single best answer 4 fractions5 fractions6 fractions7 fractions
5 fractions lvl 4
Pelger-Huet anomaly is characterized by which of the following? Please select the single best answer Giant gray-green bodies and giant lysosomes in the cytoplasm of neutrophils Bilobed or round nuclei in neutrophils (hyposegmented) Dohle-like-bodies in the cytoplasm of neutrophils Large purplish granules in the cytoplasm of all leukocytes
Bilobed or round nuclei in neutrophils (hyposegmented)
Which of the following is considered an engineering control? Please select the single best answer Face shieldBiosafety cabinetGlovesLaboratory coat
Biosafety cabinet
Which of the following characteristics of cerebrospinal fluid is present if blood is due to subarachnoid hemorrhage (SAH)? Please select the single best answer Sample clots on standing.Blood is evenly distributed in all tubes.The supernatant is clear when centrifuged within one hour.Blood is more visible in the first tube collected and less and less visible in each subsequent tube thereafter.
Blood is evenly distributed in all tubes. 4
Which type of kinetic reactions are reactions in which the enzyme is in excess and the substrate concentration is the limiting factor? Please select the single best answer Zero orderFirst orderSecond orderThird order
First order 5
Platelets are: Please select the single best answer The smallest nucleated cells seen in normal peripheral blood. The largest nucleated cells seen in normal peripheral blood. Fragments of megakaryocyte cytoplasm and do not contain nuclei Fragments of neutrophils
Fragments of megakaryocyte cytoplasm and do not contain nuclei
Which of these blood levels will decrease during intravascular hemolysis? Please select the single best answer Serum (plasma) LDH Serum (plasma) bilirubin Reticulocytes Haptoglobin
Haptoglobin
If a patient has three inactive alpha-globin genes, which of the four alpha (a) thalassemia classifications would they have? Please select the single best answer Alpha thalassemia trait Hydrops fetalis Hb H disease Silent carrier
Hb H disease
What are the two polypeptide chains that comprise the LD molecule? Please select the single best answer M and BL and DH and BM and H
M and H
Which of the following statements is true regarding primary hemostatic process resulting from vascular damage? Please select the single best answer Inhibition of platelet function by interaction with collagen.Platelet adhesion through Weibel-Palade bodies.Platelet aggregation through interaction of von Willebrand factor and glycoprotein IIb/IIIa.Rapid and immediate vasoconstriction by contraction of smooth muscles.
Rapid and immediate vasoconstriction by contraction of smooth muscles. 6
What is the nucleated cell present in the following image? Please select the single best answer OsteoblastMegakaryocyteOsteoclastMacrophage
Osteoblast 4
Which of the following cells when found upon microscopic examination of the urine would be most indicative of kidney disease: Please select the single best answer WBCs and bacteriaTubular epithelial cellsSquamous epithelial cellsRBCs
Tubular epithelial cells 2
Compared to plasma frozen within 8 hours of collection, plasma frozen within 24 hours of collection will likely have reduced levels of Factor: Please select the single best answer II VIII X XI
VIII 5
All of the following decrease medical errors in the clinical laboratory, EXCEPT: Please select the single best answer AccuracyPrecisionVarianceReduced coefficient of variation
Variance
A patient presents to the emergency room with severe headaches, nausea, and vomiting. CSF chemistry results are as follows: Protein - 74 mg/dL (15-45 mg/dL) Glucose - 53 mg/dL (40-85 mg/dL) Based on the patient's complaints and the above laboratory results what is the most probable condition? Please select the single best answer Fungal Meningitis Bacterial Meningitis Traumatic Tap Viral Meningitis
Viral Meningitis
A deficiency in which of the folowing vitamins is associated with "scurvy"? Please select the single best answer Thiamine Vitamin C Vitamin A Vitamin D
Vitamin C
Which of the following drug examples would be a good candidate for therapeutic drug monitoring (TDM)? Please select the single best answer A drug that is readily cleared A drug that has a narrow therapeutic window A drug that has a wide therapeutic window A drug that is used for short-term therapy
A drug that has a narrow therapeutic window
Leading causes for laboratory rejection of a specimen include the following reasons EXCEPT: Please select the single best answer Specimen collection tube with liquid anticoagulant not filled properlyA printed label is placed on the tube or container after specimen collectionInappropriate specimen collection tube or containerHemolyzed specimens
A printed label is placed on the tube or container after specimen collection
Which of the following is true of C-reactive protein (CRP) when being used to assess the risk of cardiovascular disease? Please select the single best answer CRP levels are high in cardiovascular disease. CRP levels are not affected by cardiovascular disease. CRP levels are low in cardiovascular disease. CRP has little clinical utility for assessing cardiovascular disease.
CRP levels are high in cardiovascular disease.
An 18-year-old female has a CBC performed as part of a routine physical exam. The following results were obtained, and the physician determines she is anemic. After reviewing her CBC results shown below, which of the following would be an appropriate description of the anemia? Parameter Value Reference Interval White blood cells (WBC) 5.6 x 109/L 4.0-10.0 x 109/L Red blood cells (RBC) 3.7 x 1012/L 4.2-5.9 x 1012/L Hemoglobin 9.9 g/dL 12-16 g/dL Hematocrit 28% 37-48% MCV 75 fL 80-100 fL RDW-CV 14% 11.0-15.0% The correct answer is highlighted below Macrocytic, heterogenous cell population Macrocytic, homogenous cell population Microcytic, heterogenous cell population Microcytic, homogenous cell population
Microcytic, homogenous cell population
The property MOST responsible for the migration of proteins in an electrical field is: Please select the single best answer Molecular weightNet surface chargeEndosmotic flowVoltage
Net surface charge 4
A 21-year-old visited her doctor. She mentioned dysuria, frequency and urgency of urination to her doctor. Which of the following urinalysis reagent strips tests would you expect to be positive for this patient based on her symptoms? Please select the single best answer KetonesBloodBilirubinNitrites
Nitrites 3
Which two of the following biomarkers are not specific to cardiac muscle and may be elevated in patients with injury to muscle other than cardiac muscle? Please select the single best answer cTnI and cTnT CK-MB and myoglobin cTnT and CK-MBMyoglobin and cTnI
CK-MB and myoglobin
A hospitalized patient has a decreased serum copper level and increased urine copper level. This is MOST consistent with: Please select the single best answer Wilson's diseaseAddison's diseaseParathyroid diseaseNot clinically significant
Wilson's disease 3
Also known as the "Right to Know" law, which of these OSHA regulations first dealt with specific information related to the contents of chemicals used in the workplace? Please select the single best answer Blood Borne Pathogens 1910.1030Formaldehyde 1910.1048Occupational Exposure 1910.1450Hazard Communication 1910.1200
Hazard Communication 1910.1200
A 55-year-old white male had the following lab data: RBC 3.7 X 1012/L Serum iron 220 µg/dL (N: 60-80 µg/dL) TIBC 300 µg/dL (N: 260-400 µg/dL) Hct 32% Serum Ferritin 2,800 ng/mL (N: 10-200 ng/mL) WBC 5.8 x 109/L MCV 86 fL MCH 26 pg MCHC 32% Prussian Blue stain of bone marrow aspirate indicates markedly elevated iron stores. These laboratory results are MOST consistent with which of the following conditions? Please select the single best answer Sideroblastic anemia Anemia of chronic disease Hemochromatosis Megaloblastic anemia
Hemochromatosis
Any health care worker who is expected to have contact with patient blood potentially infectious body fluids must be offered a vaccination for: Please select the single best answer Hepatitis BTyphoidTetanusHepatitis C
Hepatitis B
When quantifying glucose using an amperometric glucose electrode system, all of the following are components of the system, EXCEPT? Please select the single best answer Product oxidation produces a current Hydrogen peroxide is formed Hexokinase reacts with glucose Platinum electrode
Hexokinase reacts with glucose
A known sickle cell trait patient has a hemoglobin electrophoresis test performed. Which of the following hemoglobin percentage sets would most closely match this patient's diagnostic state? Please select the single best answer Hgb A = 90%, Hgb S = 8%, Hgb A2 = 2%, Hgb F = 0% Hgb A = 60%, Hgb S = 38%, Hgb A2 = 2%, Hgb F = 0% Hgb A = 40%, Hgb S = 58%, Hgb A2 = 2%, Hgb F = 0% Hgb A = 25%, Hgb S = 70%, Hgb A2 = 2%, Hgb F = 3%
Hgb A = 60%, Hgb S = 38%, Hgb A2 = 2%, Hgb F = 0%
Which of the following inclusions are composed of DNA? Please select the single best answer Howell-Jolly bodies Heinz bodies Pappenheimer bodies Döhle bodies
Howell-Jolly bodies
The primary mechanism responsible for glomerular filtration is: Please select the single best answer Osmotic gradient Concentration of blood components Rate of blood flow through the kidneys Hydrostatic differential in glomerular tufts
Hydrostatic differential in glomerular tufts
Which class of antibody can agglutinate erythrocytes (RBCs) after anti-human globulin (AHG) is added to the test tube? Please select the single best answer IgAIgEIgGIgM
IgG 2
Which of the following may be seen in a CSF sample of a patient that has a subarachnoid (intracranial) hemorrhage (SAH)? Please select the single best answer Macrophages containing hemosiderinUneven distribution of blood in CSF tubes collectedClot is present in the CSF sampleSupernatant of CSF sample does not have xanthochromia
Macrophages containing hemosiderin 7
Which of the following conditions may produce the findings indicated by the arrows in the image on the right? Please select the single best answer SepsisMay-Hegglin anomalyChediak-Higashi syndromeAlder-Reilly anomaly
May-Hegglin anomaly 4
Serum calcitonin is typically elevated in which of the following conditions? Please select the single best answer Medullary carcinoma of the thyroidHyperthyroidismGlioblastomaAdrenal adenoma
Medullary carcinoma of the thyroid 5
A 76-year-old patient experiences frequent infections and bleeding episodes. She is also complaining of pain in her bones and joints. Upon routine exam, her physician orders a complete blood count and differential. The hematology technologist notices many cells appearing similar to the cell in the image to the right. Which condition is this patient most likely suffering from? Please select the single best answer Acute Myeloid Leukemia (AML)Acute Lymphoid Leukemia (ALL)Chronic Lymphocytic Leukemia (CLL)Polycythemia Vera (PV)
Acute Myeloid Leukemia (AML) 3
Which of the following proteins has the FASTEST electrophoretic mobility? Please select the single best answer Albumin Alpha globulins Beta globulins Gamma globulins
Albumin
Which of the following proteins has the FASTEST electrophoretic mobility? Please select the single best answer AlbuminAlpha globulinsBeta globulinsGamma globulins
Albumin
Which one of the following usually shows a decrease during an acute phase response? Please select the single best answer Albumin Alpha-1 Antitrypsin Fibrinogen Ceruloplasmin
Albumin
Which of the following blood tests is used to evaluate liver function? Please select the single best answer Amylase Alkaline phosphatase (ALP) Creatinine Uric acid
Alkaline phosphatase (ALP)
Basophils' primary role involves: Please select the single best answer PhagocytosisAllergic reactionsLong term immunityFighting parasitic infections
Allergic reactions 4
Which of the following tests would be employed in order to detect neural tube defects? Please select the single best answer BilirubinL/S ratioAlpha fetoproteinCreatinine
Alpha fetoprotein
Which of the following blood tests is used to determine acute pancreatitis? Please select the single best answer Acid phosphatase Uric acid Amylase Alkaline phosphatase (ALP)
Amylase
Hormonal variation throughout the menstrual cycle typically shows: Please select the single best answer An abrupt rise in luteinizing hormone (LH) 3-36 hours prior to ovulationProgesterone peaking at ovulation then fallingEstrogen peaking at ovulation then fallingAn abrupt decrease of LH 3-36 hours prior to ovulation
An abrupt rise in luteinizing hormone (LH) 3-36 hours prior to ovulation The LH surge is required for ovulation. In fact, 3-36 hours after the LH surge, the follicle releases an ovum, which is called ovulation. After ovulation, the corpus luteum produces large amounts of progesterone while estrogen levels are also increased in order to prepare the uterus for a possible pregnancy.
The recommended storage temperature for the preservation of activity for MOST enzymes is: Please select the single best answer 0ºC4ºC25ºC37ºC
4ºC Repeated freezing and thawing should be avoided as this may denature the enzyme and inactivate its functions.
Which of these units of Red Blood Cells, that has been issued and returned to the blood bank, can be returned to inventory and is acceptable to use? Please select the single best answer A unit of Red Blood Cells that was issued 1 hour previously but not transfused and kept at room temperature. A unit of Red Blood Cells that was not transfused but stored in a temperature-controlled remote refrigerator in the operating room for 2 hours. A unit of Red Blood Cells that was issued 15 minutes previously, but returned unused with one of the sterile ports opened. A unit of Red Blood Cells that was issued to the ER with other units in a temperature controlled blood bank emergency cooler, returned to the blood bank 5 hours after issue, with internal temperature of the system reading 15o C.
A unit of Red Blood Cells that was not transfused but stored in a temperature-controlled remote refrigerator in the operating room for 2 hours.
What should safety management start with in order to ensure clarity and consistency? Please select the single best answer Laboratory supervisors who reflect the attitudes of management toward safetyProper employee conductEmployee use of personal protective equipment (PPE)A written safety policy
A written safety policy 3
The plant lectin obtained from the Dolichos biflorus plant will agglutinate which of the following? Please select the single best answer B cellsO cellsA2 cellsA1 cells
A1 cells 3
What is the MOST common infective agent to be transmitted through blood transfusion that results in morbidity and mortality? Please select the single best answer BacteriaHuman immunodeficiency virus (HIV)Hepatitis A virus (HAV)Malarial parasites
Bacteria 4
Error rates in the laboratory are estimated at what rate? Please select the single best answer Between 1:10 and 1:100 results. Between 1:32 and 1:1260 results. Between 1:164 to 1:8300 results. Between 1:250 to 1:11500 results.
Between 1:164 to 1:8300 results.
What does the hh genotype gives rise to? Please select the single best answer H substanceH secretorsBombay phenotypeh antibodies
Bombay phenotype 2
Which of the following conditions is associated with the Epstein-Barr Virus? Please select the single best answer MeaslesBurkitt's lymphomaMumpsChicken pox
Burkitt's lymphoma 3
While serum elevations are NOT generally seen in early stages, which of the following tumor markers are elevated in more advanced stages of breast cancer? Please select the single best answer CEA and AFPAFP and CA 125PSA and CA 15-3CA 15-3 and CA 549
CA 15-3 and CA 549
Which of the following patients is eligible for RhIG? Please select the single best answer D-positive woman, 28 weeks gestation, no unexpected antibodies D-negative woman, 28 weeks gestation, no unexpected antibodies D-negative woman, 28 weeks gestation, immune anti-D present in serum D-positive woman, 28 weeks gestation, anti-K present in serum
D-negative woman, 28 weeks gestation, no unexpected antibodies
A patient with renal failure is seen for blood work. What would you expect the serum calcium and phosphorus levels to be in this patient? Please select the single best answer Increased calcium and phosphorus levelsDecreased calcium and phosphorus levelsIncreased calcium but decreased phosphorus levelsDecreased calcium but increased phosphorus levels
Decreased calcium but increased phosphorus levels 5
Polymerase chain reaction (PCR) copies DNA through repeated cycles of three basic steps. What is the correct order of these steps? Please select the single best answer Extraction, annealing, denaturation Denaturation, annealing, extraction Denaturation, extension, annealing Denaturation, annealing, extension
Denaturation, annealing, extension
Which of the following antigens are well developed on fetal cells? Please select the single best answer Lewis ABO Kell I
Kell 7
Antigen processing is primarily accomplished by what type of cells? Please select the single best answer BasophilsEosinophilsPolymorphonuclear neutrophilsMacrophages
Macrophages 5
If detected in antibody screen testing, which of the following antibodies is NOT considered clinically significant in prenatal patients? Please select the single best answer Anti-M Anti-N Anti-Leb Anti-Fya
Anti-Leb
Which of the following contributes to specific gravity but does NOT contribute to osmolality? Please select the single best answer ProteinNaClUreaGlucose
Protein
After experiencing extreme fatigue and polyuria, a patient's basic metabolic panel is analyzed in the laboratory. The result of the glucose is too high for the instrument to read. The laboratorian performs a dilution using 0.25 mL of patient sample to 750 µL of diluent. The result now reads 325 mg/dL. How should the technologist report this patient's glucose result? Please select the single best answer 325 mg/dL1,300 mg/dL975 mg/dL1,625 mg/dL
1,300 mg/dL 5
The laboratory workplace includes many hours of computer use. The suggested time for a break after 30 minutes of computer use is: Please select the single best answer 1-2 minute break 3-5 minute break 5-10 minute break 20 minute break
1-2 minute break
What is the half-life of immunosuppressive drugs cyclosporine and tacrolimus? Please select the single best answer 2-4 hours4-6 hours8-10 hours10-12 hours
10-12 hours 5
In the steps involved in performing a bone marrow differential what objective is used and how many cells must be counted? Please select the single best answer 100x (oil), 100 cells 40x (oil), 100 cells 10x, 200 cells 100x (oil), 200 cells
100x (oil), 200 cells
How many grams are needed to make 1 L of a 3 M solution of HCl (gmw=36.46 g/mol)? Please select the single best answer 94.9 g HCl/ L 104.9 g HCl/L 109.4 g HCl/L 118.9 g HCl/L
109.4 g HCl/L
What is the lower reference limit for sperm concentration according to the World Health Organization, WHO Laboratory Manual for the Examination and Processing of Human Semen, WHO press, Geneva, Switzerland, 2010? Please select the single best answer 5 x 106 spermatozoa/mL 10 x 106 spermatozoa/mL 15 x 106 spermatozoa/mL 30 x 106 spermatozoa/mL
15 x 106 spermatozoa/mL
How much time must elapse between apheresis red blood cell donations? Please select the single best answer 48 hours7 days8 weeks16 weeks
16 weeks lvl 5
How many doses of RhIG should be administered if the calculated amount of fetal whole blood volume in maternal circulation was 28 mL? Please select the single best answer 1 dose 2 doses 3 doses 4 doses
2 doses
Once the seal on a unit of packed red blood cells is opened, how long can the unit be stored in the refrigerator prior to administration? Please select the single best answer 4 hours12 hours24 hours48 hours
24 hours 4
What is the increase in the risk for developing antibodies against red cell antigens (RBC alloimmunization) for patients who are characterized as chronically transfused patients? Please select the single best answer 1% - 4% 2% - 8% 5% - 10% 30% or greater
30% or greater
Approximately how many out of 1,000,000 Caucasians will have the following phenotype?Group 0, K+, Jk(a+) Please select the single best answer 10,000 30,000 100,000 600,000
30,000 6
Transfusion of which blood product is most likely to cause circulatory overload in patients? Please select the single best answer Platelets Fresh frozen plasma Red blood cells Whole blood
? FFP
Serum proteins can be separated by cellulose acetate electrophoresis into how many basic fractions: Please select the single best answer 4 fractions 5 fractions 6 fractions 7 fractions
5 fractions
Which of the following would be considered a normal value for a glucose level in cerebrospinal fluid? Please select the single best answer 30 mg/dL60 mg/dL120mg/dL150 mg/dL
60 mg/dL
Given the following information, calculate the results in mg/24 hrs for a 24-hour urine protein. Total volume for 24 hours = 2,400 mL Urine protein = 2.7 mg/dL Please select the single best answer 64.8 mg/24 hrs 10.87 mg/24 hrs 57.5 mg/24 hrs 5.89 mg/24 hrs
64.8 mg/24 hrs
Blood is diluted at 1:100 and charged on the hemocytometer counting chambers on both sides. If the average platelet count from a counting chamber in one mm2 (one large square) is 68, what is the calculated platelet count? Please select the single best answer 680,000/mm3 6,800/mm3 68,000/mm3 34,000/mm3
68,000/mm3 5
What weight of H2SO4 is contained in 200 mL of a 4 molar H2SO4 solution? (Atomic weight: H= 1; S = 32; 0 = 16) Please select the single best answer 78.4 g156.8 g39.2 g15.68 g
78.4 g
Using the formula for creatinine clearance, calculate the clearance based on the values given below: Urine creatinine: 100 mg/dLPlasma creatinine: 1.9 mg/dLUrine volume: 1375 mL/24hrsSurface Area: 1.2 m2 Round to 1 decimal place. Please select the single best answer 1.04 x 105 mL/min/m2 1.04 x 105 mL/min 72 mL/min/m2 72 mL/min
72 mL/min/m2 UV/P x 1.73/SA
From the IgG molecule illustration, which region is the heavy chain? Please select the single best answer A B C D
A A = Heavy chain B = Light chain C = Antigen binding site D = Variable region
Identify the body/frame and illuminator/diaphragm in the image to the right. Please select the single best answer B & DJ & KA & JL & F
A & J
Which of the following statements regarding the L/S ratio is TRUE? Please select the single best answer A ratio of 2:1 or greater usually indicates adequate pulmonary surfactant to prevent respiratory distress syndrome (RDS)A ratio of 1.5:1 indicates fetal lung maturity in pregnancies associated with diabetes mellitus.Sphingomyelin levels increase during the 3rd trimester causing the L/S ratio to fall slightly during the last two weeks of gestation.A phosphatidylglycerol (PG) spot indicates the presence of meconium in the amniotic fluid
A ratio of 2:1 or greater usually indicates adequate pulmonary surfactant to prevent respiratory distress syndrome (RDS) 4
What may cause the following mixing studies results? Initial aPTT = 133 seconds 1:1 Mix aPTT pre-incubation = 33 seconds 1:1 Mix aPTT post-incubation = 124 seconds Please select the single best answer Factor IX deficiencyFactor XI deficiencyA slow acting coagulation inhibitorFactor VII deficiency
A slow acting coagulation inhibitor 5
Which of the following statements is true regarding cardiovascular disease and adipose tissue? Please select the single best answer Obesity in metabolic syndrome contributes to the development of cardiovascular disease by increased synthesis and secretion of adiponectinIncreased synthesis and secretion of PAI-1 in metabolic syndrome contributes to cardiovascular disease by increasing blood pressureA state of abnormal lipids and lipid levels found in metabolic syndrome contribute to the development of cardiovascular diseaseObesity in metabolic syndrome contributes to the development of cardiovascular disease by increased synthesis and secretion of immunoglobulins
A state of abnormal lipids and lipid levels found in metabolic syndrome contribute to the development of cardiovascular disease
Which of the following fresh frozen plasma ABO types would be suitable for transfusion to an AB negative patient? Please select the single best answer AB negative only.O negative only.AB negative and AB positive only.O negative and O positive only.
AB negative and AB positive only 6
The direct antiglobulin test (DAT) is most unreliable when diagnosing hemolytic disease of the fetus and newborn due to which blood group system? Please select the single best answer ABO Duffy Rh Kidd
ABO
The accuracy of an immunoassay is its ability to discriminate between results that are true positive and results that are true negative. Two parameters of test accuracy are specificity and sensitivity. Which of these statements apply to an immunoassay with high specificity? Please select the single best answer Accurately identifies the presence of diseaseAccurately identifies the absence of diseaseHas many false-positivesHas few false-negatives
Accurately identifies the absence of disease 6
Which of the following medications is known to cause Reye's Syndrome in children? Please select the single best answer AcetaminophenIbuprofenAcetylsalicylic acidMorphine
Acetylsalicylic acid 5
When would unexpected positive reactions be encountered during ABO forward typing? Please select the single best answer A or B subgroupsAntigen depression due to leukemiaHypogammaglobulinemiaAcquired B antigen
Acquired B antigen 4
Which of the following characteristics of hemolytic disease of the fetus and newborn (HDFN) is NOT different for ABO and Rh HDFN? Please select the single best answer Disease predicted in titers Anemia at birth Antibody is IgG Bilirubin at birth
Antibody is IgG
That portion of an enzyme which when separated from its cofactor is called a(n): Please select the single best answer HoloenzymeIsoenzymeCoenzymeApoenzyme
Apoenzyme 6
Which of the following statements is true concerning apolipoproteins? Please select the single best answer All lipoprotein particles contain the same apolipoproteins.Apolipoproteins are essential for lipid metabolism.Apolipoproteins are the reason lipoproteins are atherogenic.Apolipoproteins are a type of cholesterol.
Apolipoproteins are essential for lipid metabolism.
A characteristic that distinguishes adult students from younger students is that adults: Please select the single best answer Are interested in learning from their peersAre less self-motivated since they have already established their careersTend to want to be passive studentsRespond better to individualized instruction
Are interested in learning from their peers
All of the following are likely the causes of an abnormal thrombin time (TT) EXCEPT: Please select the single best answer Fibrin split productsHeparinAspirinDysfibrinogenemia
Aspirin 6
All of the following are components of a basic single beam spectrophotometer, except: Please select the single best answer Beam splitterCuvettePrismLight source
Beam splitter 4
What is the proper lifting procedure that should be used to lift items from the floor? Please select the single best answer Kick it along with your feet.Keep your legs as straight as possible and use your back muscles.Bend your legs and lift with your leg muscles.Bend you legs, but lift with your arms as much as possible.
Bend your legs and lift with your leg muscles.
A patient has an increased RBC count with a decreased Hb and normal Hct. The MCV is microcytic, and the RDW is within normal limits. Many codocytes are present on the peripheral smear. Serum iron is 165 µg/dL (normal = 60 -150 µg/dL), and the TIBC is 230 µg/dL (normal = 250 - 400 µg/dL). Consider the findings on alkaline hemoglobin electrophoresis, which show an increased level of hemoglobin A2 of 5% (normal values are less than 3.5%). What is this patient's most likely diagnosis? Please select the single best answer Beta thalassemia silent carrierBeta thalassemia minorBeta thalassemia intermediaBeta thalassemia major
Beta thalassemia minor 5
Which of the following tests is used to quantify a coagulation inhibitor? Please select the single best answer Prothrombin timeThrombin timeMixing studyBethesda assay
Bethesda assay 6
Which of the following choices best describes the primary function of antibodies? Please select the single best answer Protection of B-lymphocytesBinds with antigenFixes complementStimulates the immune response
Binds with antigen 3
"Xanthochromic" CSF means that the color of the CSF can be any of the following EXCEPT: Please select the single best answer Pale orange Pale pink Yellow Blue
Blue
All of the following are therapeutic drugs used to treat cardiac disease, EXCEPT? Please select the single best answer Carbamazepine Digoxin Procainamide Quinidine
Carbamazepine
Which of the procedures listed below will increase the platelet concentration in the preparation of platelets? Please select the single best answer Centrifuge the blood at a low speed, remove the plasma and spin the plasma again at a low speed. Centrifuge the blood at a low speed, remove the plasma and spin the plasma again at a high speed. Centrifuge the blood at a high speed, remove the plasma and spin the plasma again at a high speed. Decrease the duration of rotation of the initial spin.
Centrifuge the blood at a low speed, remove the plasma and spin the plasma again at a high speed.
The buffering capacity of blood is maintained by a reversible exchange process between bicarbonate and: Please select the single best answer SodiumPotassiumCalciumChloride
Chloride
In blood, bicarbonate leaves the red blood cell and enters the plasma through an exchange mechanism with: Please select the single best answer SodiumPotassiumChloridePhosphorus
Chloride 4
Which of the following drugs is used to treat congestive heart failure? Please select the single best answer Disopyramide Quinidine Procainamide Digoxin
Digoxin
Essential components of compatibility testing include all of the following EXCEPT: Please select the single best answer Antibody screen on recipient's serum Major crossmatch or computer crossmatch ABO and Rh typing of recipient Direct Antiglobulin Test (DAT)
Direct Antiglobulin Test (DAT)
In serum protein electrophoresis all of the following proteins reside in the band closest to the anodal end EXCEPT: Please select the single best answer Retinol-binding protein (RBP) Transthyretin Albumin Haptoglobin
Haptoglobin
Which of the following conditions is MOST frequently associated with anti-I? Please select the single best answer Cold agglutinin diseaseHemolytic transfusion reactionDelayed transfusion reactionInfectious mononucleosis
Cold agglutinin disease 3
The arrangement of erythrocytes on this peripheral blood smear can be associated with each of the following conditions EXCEPT: Please select the single best answer Multiple myelomaCold agglutinin disordersChronic inflammatory disordersLymphoplasmacytic lymphoma
Cold agglutinin disorders 8
All of the following are learning domains that must be considered in a medical laboratory science program, EXCEPT? Please select the single best answer Cognitive Domain Affective Domain Psychomotor Domain Comprehension Domain
Comprehension Domain
Which type of control should always be negative in a molecular assay? Please select the single best answer Amplification controlInternal controlExtraction controlContamination control
Contamination control
Which of the following analytes would be increased due to delay in centrifugation? Please select the single best answer Creatinine Ionized Calcium Folate Bicarbonate
Creatinine
Which of the following analytes would be increased due to delay in centrifugation? Please select the single best answer CreatinineIonized CalciumFolateBicarbonate
Creatinine 9
The measurement of sodium and chloride in the sweat is the most useful test for the diagnosis of what condition/disease? Please select the single best answer SteatorrheaDirect determination of the exocrine secretory capacity of the pancreas.Cystic fibrosisZollinger-Ellison syndrome
Cystic fibrosis 8
Which of the following phrases best describes a segmented neutrophil? Please select the single best answer Cytoplasm appears pink-purple due to small specific granules. Cytoplasm contains large red-orange granules. Cytoplasm is a pale blue color with a ground glass appearance. Cytoplasm is clear with no granules.
Cytoplasm appears pink-purple due to small specific granules.
Which nitrogen base would bind with a guanine nucleotide in forming double-stranded DNA? Please select the single best answer CytosineUracilThymineAdenine
Cytosine 4
What is the fundamental purpose of the full, pre-transfusion crossmatch? Please select the single best answer Detect antibodies in recipient serum/plasma that react with donor red blood cells. Discover HLA antibodies in graft-versus-host situations. Verify that the donor and recipient are the same blood type. Prevent hemolytic destruction of the recipient red blood cells.
Detect antibodies in recipient serum/plasma that react with donor red blood cells.
Which of the prospective donors below would be an acceptable blood donor? Please select the single best answer Donor number 1: Blood pressure: 90/55 Pulse: 105 Temperature: 36.4ºC (97.6 ºF) Donor number 2: Blood pressure: 200/90 Pulse: 72 Temperature: 37ºC (98.6 ºF) Donor number 3: Blood pressure: 110/72 Pulse:66 Temperature: 37.2ºC (99.0 ºF) Donor number 4: Blood pressure: 100/70 Pulse: 98 Temperature: 38.3 (101.0 ºF)
Donor number 3: Blood pressure: 110/72 Pulse:66 Temperature: 37.2ºC (99.0 ºF)
What is the BEST technique for monitoring the severity of hemolytic disease of the fetus and newborn (HDFN)? Please select the single best answer Amniocentesis Doppler ultrasound Antibody titration Cordocentesis
Doppler ultrasound
A patient experiences a mild allergic reaction to a transfusion, including urticaria, erythema (skin redness), and itching. What is the most likely source of the allergen? Please select the single best answer IgA on mast cellsDrugs or food consumed by the blood donorInsoluble allergensDonor red blood cells
Drugs or food consumed by the blood donor 6
All of the following are true concerning the Erythrocyte Sedimentation Rate (ESR) EXCEPT: Please select the single best answer ESR can be used to follow the course of a disease ESR is decreased during inflammatory conditions Highest ESR values are usually seen in Multiple Myeloma ESR values are increased in rheumatoid conditions
ESR is decreased during inflammatory conditions
Which of the following is a hormone produced in the kidney that is responsible for triggering the production of red blood cells? Please select the single best answer ThrombopoietinErythropoietinThyroxineEstrogen
Erythropoietin 5
In which of the following situations would a bone marrow aspirate and biopsy be MOST LIKELY recommended to aid in diagnosis? Please select the single best answer Primary evaluation of a hypochromic/microcytic anemiaRoutine screening for hematologic complicationsPart of bone density screeningEvaluation of unexplained cytopenias
Evaluation of unexplained cytopenias 3
Which agency enforces the regulations of the Public Health Service (PHS) Act? Please select the single best answer FDACMSAABBISBT
FDA
Which of these factors may be deficient if both the PT and aPTT are prolonged? Please select the single best answer Factor II Factor VII Factor VIII Factor XI
Factor II
The National Heart, Lung, and Blood Institute (NHLBI) and American Heart Association (AHA) have created a set of parameters to define the presence of metabolic syndrome. Select the set of laboratory assays that are utilized in the NHLBI and AHA criteria for metabolic syndrome diagnosis. Please select the single best answer LDL-C, triglycerides, HDL-C, and fasting blood glucose Fasting blood glucose, triglycerides, insulin, and VLDL Fasting blood glucose, triglycerides, HDL-C Fasting blood glucose, triglycerides, HDL-C, and VLDL
Fasting blood glucose, triglycerides, HDL-C
All of the following veins are used for routine phlebotomy collection procedures, EXCEPT? Please select the single best answer Antecubital veinCephalic veinBasilic veinFemoral vein
Femoral vein 3
What would be the best way to determine how much RhIg should be given to a postpartum female who received RhIG antenatally and demonstrates the anti-D antibody at delivery? Please select the single best answer Antibody titration Flow cytometry Rosette test Kleihauer-Betke acid elution
Flow cytometry
Which type of toxicology is primarily concerned with medical and legal consequences of exposure to chemicals and drugs? Please select the single best answer Forensic toxicologyClinical toxicologyEnvironmental toxicologyDescriptive toxicology
Forensic toxicology
Regarding hemoglobin synthesis, which of the following constitutes the alpha globin chain coding? Please select the single best answer Two gene loci; one each on chromosome 11. Four gene loci; two each on chromosome 11. Two gene loci; one each on chromosome 16. Four gene loci; two each on chromosome 16.
Four gene loci; two each on chromosome 16.
Which of the following methods for long-term diabetic monitoring is recommended for patients with sickle cell anemia? Please select the single best answer FructosamineHemoglobin A1c (HbA1c)Both methods are acceptable.Neither method is acceptable.
Fructosamine 6
All of the following represent a 2 week temporary deferral from donating blood or blood products EXCEPT: Please select the single best answer Measles (rubeola) vaccine German measles (rubella) vaccine Mumps vaccine Polio vaccine
German measles (rubella) vaccine
All of the following represent a 2 week temporary deferral from donating blood or blood products EXCEPT: Please select the single best answer Measles (rubeola) vaccineGerman measles (rubella) vaccineMumps vaccinePolio vaccine
German measles (rubella) vaccine 9
Which of the following tests confirms the presence of Bence-Jones proteinuria: Please select the single best answer Protein electrophoresis Sulfosalicylic acid precipitation Cryoprecipitation Immunoelectrophoresis
Immunoelectrophoresis
Which occurrence is a medical error? Choose the correct answer and click OK. Technologist drops and breaks a bottle of chemistry reagentPatient is tested and diagnosed with acute leukemiaAnalyzer malfunctions and test results are rejected as invalidIncompatible blood is transfused into a patient during surgery
Incompatible blood is transfused into a patient during surgery
High levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) are associated with: Please select the single best answer Decreased cardiovascular riskIncreased cardiovascular riskIncreased renal failure riskIncreased liver failure risk
Increased cardiovascular risk 4
Pernicious anemia refers to cobalamin deficiency that results from a lack of which of the following? Please select the single best answer Vitamin B12 Intrinsic Factor Folate Vitamin C
Intrinsic Factor
Which of the following methods would be employed to collect sweat for chloride analysis: Please select the single best answer Electrophoresis Counter electrophoresis Iontophoresis Isoelectric focusing
Iontophoresis
The abnormal RBCs seen in this illustration are indicative of: Please select the single best answer Folic acid deficiency Vitamin B12 deficiency Chronic liver disease Iron deficiency anemia
Iron deficiency anemia
Which one of the following statements about thyroid-stimulating hormone (TSH) is true? Please select the single best answer It is decreased in hyperthyroidism. It is decreased in hypothyroidism. A sensitive TSH assay is not a good screening test for thyroid function. Diffuse toxic goiter is associated with elevated TSH levels.
It is decreased in hyperthyroidism.
If a drug is given at intervals that are the same as its half-life, approximately how long will it take the drug to reach steady state? Please select the single best answer It will be at steady state from the first dose.It will take about two half-lives to reach steady state.It will take about 5-7 half-lives to reach steady state.It will never reach a steady state.
It will take about 5-7 half-lives to reach steady state. about 5 to 7 half-lives to reach steady state (the equilibrium between drug dosing and elimination). By 5-7 doses, the amount of single dose administered is equal to the amount of drug eliminated by the patient during the dosage period.
Which of the following characteristics is consistent with the Kidd blood group system? Please select the single best answer Jk(a-b-) red cells are resistant to lysis in 2 M ureaKidd antigens are destroyed by ficinAntibodies to Kidd antigens react best at immediate spinAnti-Jka activity may not react well in a LISS test system
Jk(a-b-) red cells are resistant to lysis in 2 M urea 6
Nitric oxide is associated with the prevention of vaso-occlusion by decreasing cellular adherence to endothelium. Which amino acid is decreased in patients with sickle cell disease and is needed as a substrate to produce nitric oxide? Please select the single best answer L-arginineL-glutamineL-lysineL-tyrosine
L-arginine 8
Which term describes the dose of the drug in which 50% of the individuals will result in mortality? Please select the single best answer ED50 LD50 TD50 MD50
LD50
Lewis Blood Group System is a human blood group unlike most others. The antigen is produced and secreted by exocrine glands, eventually adsorbing to the surface of red blood cells. Its expression is based on the genetic expression of the Lewis and Secretor genes. Based on the following genotype (Le) (sese), what would you predict the Lewis antigen phenotypic expression to be? Please select the single best answer Le(a- b-)Le(a+ b+)Le(a+ b-)Le(a- b+)
Le(a+ b-) 6
Which one of the following blood group antigens is not expressed, or only weakly expressed on cord blood cells? Please select the single best answer K ABO M Leb
Leb
What part of an immunoglobulin (Ig) molecule exists as kappa or lambda chains? Please select the single best answer Fc Fab Heavy chains Light chains
Light chains
All of the following are sites of active hematopoiesis in the adult EXCEPT: Please select the single best answer Skull Ribs Liver Pelvis
Liver
All of the following are causes of hypernatremia EXCEPT: Please select the single best answer Excess water loss Low aldosterone production Decreased water intake Increased sodium intake or retention
Low aldosterone production
Which of the following sources of error will give a false negative result in antihuman globulin testing? Please select the single best answer Low pH of salineDirty glasswareSamples collected in gel separator tubesRefrigerated specimen
Low pH of saline 6
Which of the following cells have pale blue cytoplasm with a few azurophilic granules and an oval or indented nucleus? Please select the single best answer Monocyte Segmented neutrophil Eosinophil Lymphocyte
Lymphocyte
Which of the following is NOT classified as a Myelodysplastic Syndrome? Please select the single best answer MDS with Philadelphia Chromosome (MDS-PC)MDS with Ring Sideroblasts (MDS-RS)MDS with Single Lineage Dysplasia (MDS-SLD)MDS with Excess Blasts (MDS-EB)
MDS with Philadelphia Chromosome (MDS-PC) 5
Which of the following situations suggest a traumatic tap occurred? Please select the single best answer More blood is in tube 1 than tubes 2, 3, or 4. Immediate centrifugation reveals pink supernatant. All collected specimens have an oily appearance. 3+ turbidity is present.
More blood is in tube 1 than tubes 2, 3, or 4.
The following diagram demonstrates two Serum Protein Electrophoresis (SPEP) patterns from different patients. The pattern on the left appears to be from a normal, healthy patient. The pattern on the right is from a patient with a particular disorder. What disorder is suggested by the pattern on the right? Please select the single best answer Nephrotic SyndromeAcute inflammationMalnutritionMultiple Myeloma
Multiple Myeloma
This serum protein electrophoresis (SPE) scan most likely represents which of the following disease states: Please select the single best answer Chronic inflammationMyocardial infarctionLiver diseaseMultiple myeloma
Multiple myeloma There is a tall narrow peak in the beta region, with decreased normal immunoglobulins in the gamma region. This pattern is most likely due to multiple myeloma, with a relatively fast migrating monoclonal protein present.
The upper image of a peripheral blood smear reveals RBC rouleaux formation. Several blood cells that are similar to the one indicated by the arrow in the bottom image are also seen on the smear. Which of the following conditions is associated with both of these findings? Please select the single best answer Multiple myelomaInfectious mononucleosisChronic lymphocytic leukemiaNormal peripheral blood smear findings
Multiple myeloma 4
You are collecting a blood specimen to be used for forensic (legal) alcohol testing. Which of the following must be done before you can start the specimen collection process? Please select the single best answer Label the tubes in the presence of the patient. Must inform the patient that the blood about to be collected is for alcohol testing. Seal the collection tubes in front of the patient. Collect the specimen, the patient does not need to be informed what the blood is collected for.
Must inform the patient that the blood about to be collected is for alcohol testing.
A CLIA waived test requires that operators: Please select the single best answer Must perform QC dailyDemonstrate competency annuallyMust attend training seminarMust follow manufacturer's instructions
Must perform QC daily
The mutational status of Janus kinase 2 (JAK2) is most commonly used for the diagnosis of which of the following? Please select the single best answer Paroxysmal Nocturnal Hemoglobinuria (PNH) Myeloproliferative neoplasms Anemias due to nutritional deficiencies Hypoproliferative conditions
Myeloproliferative neoplasms
Which of these United States' federal agencies has the responsibility of enforcing the Bloodborne Pathogens Standard? Please select the single best answer Food and Drug Administration (FDA) Occupational Safety and Health Administration (OSHA) Centers for Medicare and Medicaid Services (CMS) Centers for Disease Control and Prevention (CDC)
Occupational Safety and Health Administration (OSHA)
How does the laboratory immunologic assessment of Waldenstrom's Primary Macroglobulinemia differ from other monoclonal gammopathies? Please select the single best answer Frequently an increase in IgG, possibly an M spike on serum protein electrophoresis. Overproduction of IgM antibodies. Only kappa or lambda monoclonal light chains or Bence-Jones protein seen on serum protein electrophoresis. Characterized by the presence of monoclonal proteins composed of the heavy chain portion of the immunoglobulin molecule.
Overproduction of IgM antibodies.
Warfarin-based (coumarin derivative) oral anti-coagulant therapy is commonly monitored with : Please select the single best answer APTT PT/INR APTT and PT Thrombin time
PT/INR 3
Which of the following red cell inclusions are often found in peripheral blood smears of patients with sideroblastic anemia? The correct answer is highlighted below Howell-Jolly bodies Pappenheimer bodies Heinz bodies Cabot rings
Pappenheimer bodies
Which of the following types of automated chemistry analyzers allows for all specimens to be analyzed at the same time? Please select the single best answer Discrete analyzer Random access analyzer Multi-channel analyzer Parallel analyzer
Parallel analyzer
A patient has a history of repeated spontaneous abortion. Coagulation studies reveal an elevated APTT, normal PT, normal platelet function, and normal thrombin time. Schistocytes were seen on the peripheral blood smear. Which test should be performed to determine if the patient has lupus anticoagulant? Please select the single best answer Factor VIII assay Mixing studies with factor-deficient plasmas Antinuclear antibody test Platelet neutralization test
Platelet neutralization test
What procedure utilizes leukapheresis to collect the buffy coat from whole blood? Please select the single best answer Photopheresis Plasmapheresis Therapeutic apheresis Erythrocytapheresis
Photopheresis
All of the following are directly involved in the production of semen EXCEPT? Please select the single best answer Prostate Pituitary gland Seminal vesicles Bulbourethral gland
Pitutary gland
A white blood cell stained with Wright's stain has the following characteristics: Round eccentric nucleus with clumped chromatin pattern 1:1 nucleus to cytoplasm ratio Basophilic cytoplasm Crescent-shaped clear area next to nucleus What is the MOST likely identification of this cell? Please select the single best answer Myeloblast Plasma cell Reactive lymphocyte Polychromatic normoblast
Plasma cell
There are several different types of media that can be used in electrophoresis. Most methods today use a gel - cellulose acetate, agarose, or polyacrylamide gel. Which one of the following statements is true regarding these gels? Please select the single best answer The compounds used to make cellulose acetate gels are carcinogenic Polyacrylamide gels are composed of polysaccharides and acrylamides Polyacrylamide gels have the greatest resolution or separation of solutes Cellulose acetate and agarose gels are the more commonly used gels
Polyacrylamide gels have the greatest resolution or separation of solutes
In 1983, Kary Mullis visualized the idea of amplifying DNA while working on a new mutation detection method. What is this process that he later discovered utilizing this idea? Please select the single best answer KaryotypingWestern blotPolymerase chain reactionHigh-performance liquid chromatography
Polymerase chain reaction 5
Which of the following is an example of a macroscopic urinalysis abnormality? Please select the single best answer Glitter cellsPositive proteinWaxy castsRed blood cell casts
Positive protein 5
Which of the following analytes will be falsely increased due to hemolysis? Please select the single best answer Hemoglobin, Hematocrit, Red Blood Cell CountHematocrit, Red Blood Cell Count, PotassiumPotassium, Magnesium, Iron, Total ProteinHemoglobin, Hematocrit, Magnesium, Iron, Total Protein
Potassium, Magnesium, Iron, Total Protein
A solution of gamma globulins containing anti-Rh(D) is given to an Rh(D) negative mother to: Please select the single best answer Prevent fetal cells from initially sensitizing the mother Neutralize any of the child's antibody that may have passed the placental barrier Neutralize any natural maternal antibodies present Prevent greater antibody response in a previously sensitized mother
Prevent fetal cells from initially sensitizing the mother
Fluorometers are designed so that the path of the excitation light is at a right angle to the path of the emitted light. What is the purpose of this design? Please select the single best answer Prevent the loss of emitted lightPrevent the loss of the excitation lightFocus emitted and excitation light upon the detectorPrevent incident light from striking the detector
Prevent incident light from striking the detector
All of the following are reasons for conducting compatibility testing EXCEPT: Please select the single best answer Prevent recipient alloimmunization Verify ABO and Rh Select proper blood products Detect antibodies against donor cells
Prevent recipient alloimmunization
What are apolipoproteins? Please select the single best answer Small spheres that carry lipids through the blood that aid in lipid transport to their sites of metabolism.Proteins that are found on only high-density lipoproteins.Pseudo-proteins, since lipid particles are not alive and thus cannot make proteins.Proteins that are on the surface of lipoprotein molecules and bind enzymes or transport specific proteins and direct lipoproteins to their sites of metabolism.
Proteins that are on the surface of lipoprotein molecules and bind enzymes or transport specific proteins and direct lipoproteins to their sites of metabolism.
Which of the following laboratory tests is commonly used to monitor oral anticoagulant therapy? Please select the single best answer Activated partial thromboplastin time (APTT)Thrombin time (TT)Prothrombin time (PT)/INRFibrinogen assay
Prothrombin time (PT)/INR 3
All of the following are included in a quality control program, EXCEPT? Please select the single best answer Protocol to identify problems in equipmentProtocol to correct problems in equipmentProtocol to monitor problems in equipmentProtocol to prove patient results are correct
Protocol to prove patient results are correct
Which of the following tests require a 72-hour stool (fecal) collection? Please select the single best answer Occult blood Quantitative fecal fat Ova and Parasite (O&P) Stool culture
Quantitative fecal fat
All of the following are primary functions of the kidney, EXCEPT? Please select the single best answer Acid-base balance Retention of essential nutrients and water Reabsorption of waste products Blood filtration
Reabsorption of waste products
The kidneys perform all of the following functions EXCEPT: Please select the single best answer Acid-base balance Hormone production Reabsorption of waste products Water and electrolyte balance
Reabsorption of waste products
Which of the following suggestions will help to avoid glare? Please select the single best answer Use fluorescent lightingUse the brightest light possiblePlace the light as close to the work area as possibleReflect the light away from the eyes
Reflect the light away from the eyes
All of the following factors offer a protective effect, delaying symptoms in persons with hereditary hemochromatosis (HH) EXCEPT? Please select the single best answer Regular blood donation Pregnancy Regular use of multivitamins with iron Menstruation
Regular use of multivitamins with iron
The prozone effect can be described by all of the following EXCEPT: Please select the single best answer Results in a false negative reactionThe result of antibody excessDilution of antibody can help prevent its occurrenceResults in a false positive reaction
Results in a false positive reaction 4
Laboratory Operations Manual/Automated Methodology and Instrumentation Molecular Methods What type of graph is needed in a real-time PCR in order to perform absolute quantification? Please select the single best answer Standard curveAmplification curveMelt CurveQuantification curve
Standard
Mercury covered by a layer of mercurous chloride in contact with saturated potassium chloride solution describes which of the following types of electrodes? Please select the single best answer Standard hydrogenSaturated CalomelRedoxSilver/Silver chloride
Saturated Calomel
Which of the following is true of the nuclear appendage seen in this image? Please select the single best answer Seen only in women Seen only in men Seen in both sexes Seen in dwarfs only
Seen only in women
All of the following are types of quality and process improvement tools, EXCEPT: Please select the single best answer Six SigmaLeanSentinel eventsRoot-cause analysis
Sentinel events
A cloudy, yellow-green synovial fluid with 122,000 WBCs which are predominantly neutrophils, and a decreased glucose, would be classified as: Please select the single best answer NoninflammatoryInflammatorySepticCrystal-induced
Septic 4
Patients with Cushing's disease typically exhibit: Please select the single best answer Decreased plasma 17-hydroxysteroid concentration Decreased urinary 17-hydroxysteroid excretion Serum cortisol overproduction Decreased cortisol secretion rate
Serum cortisol overproduction
Which one of the following statements about lead poisoning is false? Please select the single best answer While lead distributes to all tissues, the central nervous system, kidney, and bone marrow are particularly susceptible to lead toxicityWhole blood lead measurement is the best test for detecting lead toxicitySerum lead level is a good inexpensive screening test for lead toxicityLead levels below 5 µg/dL in children do not prompt ongoing monitoring
Serum lead level is a good inexpensive screening test for lead toxicity 6
Why are small dense LDL molecules more atherogenic? Please select the single best answer Small dense LDL molecules contain less cholesterol and phospholipid.Small dense LDL molecules increase the concentration of HDL-C in the blood.Small dense LDL molecules increase the concentration of adiponectin and inflammatory cytokines.Small dense LDL molecules have greater mobility in the endothelium and arterial wall.
Small dense LDL molecules have greater mobility in the endothelium and arterial wall.
C-reactive protein (CRP) is often used as a marker of inflammation. However, it has a low _________. Please select the single best answer SensitivitySpecificityAccuracyPrecision
Specificity
A comprehensive, final exam in a hematology lecture course is considered a: Please select the single best answer Formative testPlacement testCertification testSummative test
Summative test
Which of the following immunosuppressive drugs below has been associated with thrombus formation in patients with toxic levels? Please select the single best answer Tacrolimus Cyclosporine Sirolimus Mycophenolic acid
Tacrolimus
Serum TSH levels five times the upper limit of normal in the presence of a low T4 and low T3 uptake could mean which of the following? Please select the single best answer The thyroid has been established as the cause of hypothyroidism.The thyroid is ruled out as the cause of hypothyroidism.The pituitary has been established as the cause of hypothyroidism.The diagnosis is consistent with secondary hyperthyroidism.
The thyroid has been established as the cause of hypothyroidism
The following BEST describes serum hCG levels during pregnancy: Please select the single best answer Rise in levels throughout pregnancy Highest levels found at end of pregnancy The rapid rise in levels during the first trimester; slow decline and possible level-off throughout the remainder of the pregnancy The slow rise in levels during the first trimester; rapid rise during the second trimester; slow decline during the third trimester
The rapid rise in levels during the first trimester; slow decline and possible level-off throughout the remainder of the pregnancy
What is a typical finding for determining the endpoint for the initial or iron-depletion phase of treatment for hereditary hemochromatosis (HH)? Please select the single best answer The serum ferritin decreases to between 20 and 50 ng/mLThe hepatic iron index returns to normalThe transferrin saturation drops below 20%The serum iron falls to below 35 µg/dL.
The serum ferritin decreases to between 20 and 50 ng/mL 6
A jaundiced newborn's bilirubin values are as follows: DayTimeBilirubin value12/28/20157:45 am14 mg/dL12/29/20157:15 am13 mg/dL12/30/20158:00 am4 mg/dL What is the explanation for these test results? Please select the single best answer This is a case of diurnal variation, the specimens should have been collected at the exactly the same time for all three days.The ultraviolet light placed on the newborn broke down the bilirubin and dramatically decreased the value.The specimen was not protected from light and bilirubin broke down resulting in a false decreased value.These are normal test results, there should be no concern.
The specimen was not protected from light and bilirubin broke down resulting in a false decreased value.
In reference to semen analysis microscopic examination, differentiation, and enumeration of "round cells" which are often present in semen count are referred as: Please select the single best answer Sperm vitalitySeminal fluid fructoseWhite blood cells (WBCs)Bacteria
White blood cells (WBCs) 5
Which of the following statements is TRUE for specific gravity measured by the urine chemical reagent strip method? Please select the single best answer High concentrations of protein in urine do not increase the readings when using the urine chemical reagent strip. An alkaline pH would not affect the specific gravity result using a reagent strip method. The urine chemical reagent strip method is not affected by the presence of x-ray contrast media in the urine specimen. The urine chemical reagent strip method is based on the fact that light is refracted in proportion to the amount of total solids dissolved in the urine.
The urine chemical reagent strip method is not affected by the presence of x-ray contrast media in the urine specimen.
When operating a centrifuge, what happens if the centrifugation time is reduced and the speed increased? Please select the single best answer The potential breakage of collection tube is highly increased.There is increased chance of exposure to biohazardous agents.There will be incomplete separation of red blood cells and serum in the tube.Mechanical damage to the centrifuge may occur.
There will be incomplete separation of red blood cells and serum in the tube.
The pH of a protein is 9.2. This protein is placed in an electrical field where a buffer sets the pH at 10.0. Select the correct statement regarding the electrophoretic migration of this protein. Please select the single best answer This protein will have a net positive charge and will migrate to the anode, the positively charged electrodeThis protein will have a net positive charge and will migrated toward the cathode, the negatively charged electrodeThis protein will have a net negative charge and will migrate toward the anode, the positively charged electrodeThis protein will have a net negative charge and will migrate to the cathode, the negatively charged electrode
This protein will have a net negative charge and will migrate toward the anode, the positively charged electrode. If the pH for electrophoresis is above the pI of a protein, the protein will have a net negative charge. Negative ions, anions, will migrate to the positively charged electrode, the anode.
Aspirin ingestion prevents the synthesis of this signaling molecule in the platelet? Please select the single best answer Thromboxane A2 Calcium Collagen ADP
Thromboxane A2
All of the following affect the relative centrifugal force of a centrifuge, EXCEPT? Please select the single best answer Revolutions per minute (RPM)TimeRadius of centrifugeA constant of 1.12 x10-5
Time The Relative Centrifugal Force (RCF) is equal to (1.12 x 10-5 )(radius of centrifuge)(revolutions per minute).
Which of the following use target amplification methodologies? Please select the single best answer Transcription mediated amplification (TMA)Fluorescence in situ hybridization (FISH)Northern BlotBranched chain DNA (bDNA)
Transcription mediated amplification (TMA)
Chylomicrons are primarily composed of: Please select the single best answer Cholesterol Triglycerides Phospholipids Proteins
Triglycerides
Which of the following signs and symptoms may be associated with immediate transfusion reaction, but is NOT usually associated with delayed hemolytic transfusion reaction? Please select the single best answer Fever and chills Unexplained bleeding from surgical site Unexplained drop in hemoglobin Transient jaundice
Unexplained bleeding from surgical site
When performing an anti-human globulin (AHG) test, it is important to completely wash the red cells because: Please select the single best answer Washing eliminates concentrations of unbound antigens.Washing prevents elution of cell-bound antibody.Washing promotes false positive effects of rouleaux.Washing prevents neutralization of the anti-human globulin (AHG) serum.
Washing prevents neutralization of the anti-human globulin (AHG) serum. 6
Which of the following common laboratory analytes is most often increased in newborns due to the newborn crying violently? Please select the single best answer White blood cell count (WBC)PotassiumRed blood cell count (RBC)Sodium
White blood cell count (WBC)
Select the statement that best describes high sensitivity CRP (hs-CRP) testing? Please select the single best answer. hs-CRP is a measurement of acute inflammation and is used to monitor these types of conditions hs-CRP is an anti-inflammatory adipokine synthesized by adipocytes hs-CRP is a marker of chronic inflammation and measured to predict the risk of cardiovascular disease hs-CRP is decreased in inflammatory conditions and measured to predict a return of inflammation
hs-CRP is a marker of chronic inflammation and measured to predict the risk of cardiovascular disease 4
Which type of antibodies are known to cause transfusion-related acute lung injury (TRALI) reactions? Please select the single best answer Red cell antibodies Platelet antibodies HLA antibodies Both red cell antibodies and platelet antibodies
HLA antibodies
Which of the marrow cells from the list below has highly granular basophilic cytoplasm but does not show nuclear lobules? Please select the single best answer Macrophage Mast cell Lipocyte Osteoblast
Mast cell
CD5 antigen is normally found on which of the following lymphocyte populations? Please select the single best answer Mature T cells Normal B cells Both mature T cells and normal B cells None of the above, CD5 is not a lymphoid marker
Mature T cells
What does the M:E ratio in a bone marrow evaluation represent? Please select the single best answer Monocytes to erythrocytes Myeloid cells to erythroid cells Myelocytes to erythrocytes Megakaryocytes to erythrocytes
Myeloid cells to erythroid cells
Why is Rh immune globulin (RhIg) administered within 72 hours of delivery to an Rh negative mother if the newborn is found to be D-positive or weak-D positive? Please select the single best answer Prevent future children from producing antibodies Prevent fetal cells from initially sensitizing the mother Prevent antibody response in a previously sensitized mother Neutralize any natural maternal antibodies present
Prevent fetal cells from initially sensitizing the mother
A smear that is prepared from equal parts of new methylene blue and whole blood is used for which of the following? Please select the single best answer WBC differential Platelet estimate Reticulocyte count Manual RBC count
Reticulocyte count
A patient suffering from Celiac disease and Crohn's disease (both inflammatory conditions of the GI tract) is given a new oral medication that has a narrow therapeutic window. Which of the following would be true? Please select the single best answer Oral medication is never effective for a patient that has these diseases. The drug must be given through IV. Toxicity in this patient is not likely since most of the drug won't be absorbed. Therapeutic drug monitoring (TDM) would be helpful to see how much drug has been absorbed. Serum drug levels obtained 15 minutes after the oral dose should confirm the drug was absorbed.
Therapeutic drug monitoring (TDM) would be helpful to see how much drug has been absorbed.
TIBC (total iron-binding capacity) is an indirect measurement of which of the following: Please select the single best answer Ferritin Hemoglobin Ceruloplasmin Transferrin
Transferrin
What is considered the cause of urticarial transfusion reactions? Please select the single best answer IgA deficient individuals receiving plasma products containing IgA IgG or IgM antibody along with complement Tissue damage from the formation of immune complexes Transfusion of certain food allergens or drugs in plasma products
Transfusion of certain food allergens or drugs in plasma products
A cerebrospinal fluid sample was taken from an inpatient with severe neurological symptoms. The image shows a field from a cytospin preparation from this patient's fluid. What findings are present in this field? Please select the single best answer Blast cells Mesothelial cells Choroid plexus clump Tumor cells
Tumor cells