Meperidine

MAO inhibitors

Contraindicated with patients taking:

CNS neurotoxicity, tachycardia, less apt to cause bilary tract pressure, less constipating, less antitussive action, duration of action shorter, poor oral bioavailability

Difference from Morphine:

600mg/24hr

Dosage should not exceed:

May increase plasma amylase/lipase concentrations

Drug-lab tests:

Pain, anesthesia adjunct, analgesic during labor, preoperative sedation

Indications:

Short term (<48hr)

Meperidine is a synthetic opioid for short or long term use?

Allergicc to or intolerant of all other opioids

Meperidine is recommended to be used only in patients who are either:

Obstetric use

Preferred drug for:

Seizures, anaphylaxis, confusion, sedation, hypotension, constipation, nausea, vomiting

Side/adverse effects:

Demerol

Trade name:

Short half life, interacts adversely with number of drugs, risk of harm owing to accumulation of a toxic metabolite

Why has use declined?

Yields a toxic metabolite when given in doses to provide adequate pain relief

Why is Demerol unsafe?

Fatalities

Accidental overdose may result in:

5 mins; increased respiratory depression, hypotension, and circulatory collapse

Administer slowly over how long? May result in?

Naxalone

Antidote:

Type/location/intensity of pain, BP/pulse/respirations, bowel function, chronic/high-dose therapy for CNS stimulation

Assess before/monitor: