Meperidine
MAO inhibitors
Contraindicated with patients taking:
CNS neurotoxicity, tachycardia, less apt to cause bilary tract pressure, less constipating, less antitussive action, duration of action shorter, poor oral bioavailability
Difference from Morphine:
600mg/24hr
Dosage should not exceed:
May increase plasma amylase/lipase concentrations
Drug-lab tests:
Pain, anesthesia adjunct, analgesic during labor, preoperative sedation
Indications:
Short term (<48hr)
Meperidine is a synthetic opioid for short or long term use?
Allergicc to or intolerant of all other opioids
Meperidine is recommended to be used only in patients who are either:
Obstetric use
Preferred drug for:
Seizures, anaphylaxis, confusion, sedation, hypotension, constipation, nausea, vomiting
Side/adverse effects:
Demerol
Trade name:
Short half life, interacts adversely with number of drugs, risk of harm owing to accumulation of a toxic metabolite
Why has use declined?
Yields a toxic metabolite when given in doses to provide adequate pain relief
Why is Demerol unsafe?
Fatalities
Accidental overdose may result in:
5 mins; increased respiratory depression, hypotension, and circulatory collapse
Administer slowly over how long? May result in?
Naxalone
Antidote:
Type/location/intensity of pain, BP/pulse/respirations, bowel function, chronic/high-dose therapy for CNS stimulation
Assess before/monitor: