cb final quiz qs

events of M phase into the correct order 1. Alignment of the chromosomes at the spindle equator 2. Attachment of microtubules to chromosomes 3. Breakdown of nuclear envelope 4. Reformation of the nuclear envelope 5. Condensation of the chromosomes 6. Separation of sister chromatids

5,3,2,1,6,4

Which of the following statements is CORRECT

A gain-of-function mutation in only one allele of oncogene can stimulate cell survival or division.

Which of the following statements is FALSE?

A loss-of-function mutation of telomerase will convert a normal cell to a cancer cell.

Which of the following statements about cancer is FALSE?

A mutation in a single cancer-critical gene is sufficient to convert a normal cell into a cancer cell.

Which of the following statements about apoptosis is TRUE?

Apoptosis can be promoted by the release of cytochrome c into the cytosol from mitochondria.

What would be the consequence of inactivation of E2F?

Cells would be unable to enter the S phase.

If the anaphase promoting complex (APC/C) is temperature sensitive (active at 30 degree, but inactive at 40 degree), shifting to the higher temperature (40 degree) at the start of M phase would prevent which of the following?

Degradation of securin and separation of sister chromatids.

Irradiated mammalian cells usually stop dividing and arrest at a G1 checkpoint. Place the following events in the order in which they occur. I. production of p21 II. DNA damage III. inhibition of cyclin-Cdk complexes IV. activation of p53

II-IV-I-III

which of the following is true

In anaphase B, microtubules associated with the cell membrane shorten.

Which of the following transcription factors is needed to convert an adult cell into an induced pluripotent stem (iPS) cell? Sox2 Oct4 Klf4 All of the above

all of the above

A multipotent cell _________.

an give rise to some cell types in the body

An adult hematopoietic stem cell found in the bone marrow ______________________.

can undergo self-renewing divisions for the lifetime

A cell with mutated lamins that cannot be phosphorylated in M phase will be unable to

disassemble its nuclear lamina at prometaphase.

in DNA replication, the lagging strand is synthesized discountinously at the replication fork because...

dna polymerase can polymerize nucleotides only in the 5'- to -3' direction

A malignant tumor is more dangerous than a benign tumor because its cells ________________.

invade other tissues

A particular strain of yeast produces strains with a mutant cdc2 (M-Cdk) gene, resulting in little to no production of the M-Cdk protein kinase. As a result, what would be expected? These cells will have chromosome condensation. These cells will have the nuclear envelope disperse. These cells will enter M phase. None of these.

none of these

Embryonic stem cells are such a powerful possible treatment for disease because they are______.

pluripotent

When a terminally differentiated cell in an adult body dies, it can typically be replaced in the body by a stock of ________.

proliferating precursor cells that are derived from adult stem cells

in the cell containing loss of function mutation of the separate gene, which of the following phenotypes can be predicted

sister chromatids will not be segregated after metaphase

Progression through the cell cycle requires a cyclin to bind to a Cdk because _________.

the binding of a cyclin to Cdk is required for Cdk enzymatic activity