Growth Factors
Transforming Growth Factor alpha (TGF-alpha) Source
Activated macrophages, keratinocytes, many others
Epidermal Growth Factor (EGF) Source
Activated macrophages, salivary glands, keratinocytes, many others
Fibroblasts Growth Factors (FGFs), including acidic (FGF-1) and basic (FGF-2) Functions
Chemotactic and mitogenic for fibroblasts; stimulates angiogenesis, and ECM protein synthesis
Transforming Growth Factor-Beta (TGF-Beta) Functions
Chemotactic for leukocytes and fibroblasts; stimulates ECM protein synthesis; suppresses acute inflamation
Platelet-derived growth factor (PDGF) Functions
Chemotactic for neutrophils, macrophages, fibroblasts, and smooth muscle cells; activates and stimulates proliferation of fibroblasts, endothelial, and other cells; stimulates ECM protein synthesis
Hepatocyte Growth Factor (HGF) (scatter factor) Function
Enhances proliferation of endothelial cells and other epithelial cells. Increases cell motility
Keratinocytes growth factor (KGF) Sources
Fibroblasts
Hepatocyte Growth Factor (HGF) (scatter factor) Sources
Fibroblasts, stromal cells in liver, endothelial cells
Fibroblasts Growth Factors (FGFs), including acidic (FGF-1) and basic (FGF-2) Sources
Macrophages, mast cells, endothelial cells, many other cell types
Vascular Endothelial Growth Factor (VEGF) Sources
Mesenchymal Cells
Epidermal Growth Factor (EGF) Functions
Mitogenic for keratinocytes and fibroblasts: stimulates keratinocyte migration; stimulates formation of granular tissue
Transforming Growth Factor-Beta (TGF-Beta) Sources
Platelets, T Lymphocytes, macrophages, endothelial cells, keratinocytes, smooth muscle cells, fibroblasts
Platelet-derived growth factor (PDGF) Sources
Platelets, macrophages, endothelial cells, smooth muscle cells, keratinocytes
Keratinocytes growth factor (KGF) Functions
Stimulates keratinocyte migration, proliferation, and differentiation
Vascular Endothelial Growth Factor (VEGF) Functions
Stimulates proliferation of endothelial cells, increase vascular permeability
Transforming Growth Factor alpha (TGF-alpha) Functions
Stimulates proliferation of hepatocytes and other epithelial cells
