Growth Factors

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Transforming Growth Factor alpha (TGF-alpha) Source

Activated macrophages, keratinocytes, many others

Epidermal Growth Factor (EGF) Source

Activated macrophages, salivary glands, keratinocytes, many others

Fibroblasts Growth Factors (FGFs), including acidic (FGF-1) and basic (FGF-2) Functions

Chemotactic and mitogenic for fibroblasts; stimulates angiogenesis, and ECM protein synthesis

Transforming Growth Factor-Beta (TGF-Beta) Functions

Chemotactic for leukocytes and fibroblasts; stimulates ECM protein synthesis; suppresses acute inflamation

Platelet-derived growth factor (PDGF) Functions

Chemotactic for neutrophils, macrophages, fibroblasts, and smooth muscle cells; activates and stimulates proliferation of fibroblasts, endothelial, and other cells; stimulates ECM protein synthesis

Hepatocyte Growth Factor (HGF) (scatter factor) Function

Enhances proliferation of endothelial cells and other epithelial cells. Increases cell motility

Keratinocytes growth factor (KGF) Sources

Fibroblasts

Hepatocyte Growth Factor (HGF) (scatter factor) Sources

Fibroblasts, stromal cells in liver, endothelial cells

Fibroblasts Growth Factors (FGFs), including acidic (FGF-1) and basic (FGF-2) Sources

Macrophages, mast cells, endothelial cells, many other cell types

Vascular Endothelial Growth Factor (VEGF) Sources

Mesenchymal Cells

Epidermal Growth Factor (EGF) Functions

Mitogenic for keratinocytes and fibroblasts: stimulates keratinocyte migration; stimulates formation of granular tissue

Transforming Growth Factor-Beta (TGF-Beta) Sources

Platelets, T Lymphocytes, macrophages, endothelial cells, keratinocytes, smooth muscle cells, fibroblasts

Platelet-derived growth factor (PDGF) Sources

Platelets, macrophages, endothelial cells, smooth muscle cells, keratinocytes

Keratinocytes growth factor (KGF) Functions

Stimulates keratinocyte migration, proliferation, and differentiation

Vascular Endothelial Growth Factor (VEGF) Functions

Stimulates proliferation of endothelial cells, increase vascular permeability

Transforming Growth Factor alpha (TGF-alpha) Functions

Stimulates proliferation of hepatocytes and other epithelial cells


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