Immune ATI Pharm
HCP caring for pt receiving IV carmustine (BiCNU) for multiple myeloa. Pt is at greatest risk for infection when after time of infusion? 4 to 6 weeks 24 hr 1 week 2 weeks
4-6 weeks Carmustine, a nitrosourea drug, can cause delayed bone marrow suppression. Thrombocytes and leukocytes reach nadirs at 4 to 6 weeks following IV infusion. The patient should use hand hygiene often and wash fruits and vegetables thoroughly. It is crucial to avoid contact with crowds and people who have communicable infections.
HCP about to admin IV paclitaxel (Taxol) to pt w/ ovarian ca. Which of the following actions should HCP take? SATA Add heparin to the paclitaxel solution. Administer the drug through non-PVC tubing. Infuse the drug over 1 hr. Give the patient an antihistamine. Use an in-line filter.
Administer the drug through non-PVC tubing. Give the patient an antihistamine. Use an in-line filter.
HCP should understand that enfuvirtide (Fuzeon) is appropriate for pts w/ which of the following? Primary brain tumors Advanced HIV disease Advanced prostate cancer Metastatic ovarian cancer
Advanced HIV Enfuvirtide, a fusion inhibitor, treats HIV disease that is advanced or resistant to other types of treatment. Health care professionals should always give the drug along with other antiretroviral drugs.
HCP caring for pt about to begin tamoxifen (Soltamox) for BC. HCP should recognize need for cautious use of the drug if pt also has which of the following? Alcohol use disorder DM COPD Cataracts
Cataracts Tamoxifen, an estrogen-receptor blocker, can cause retinopathy, cataracts, and decreased visual acuity. Its use requires caution with patients who already have cataracts.
HCP caring for pt about to begin maraviroc (Selzentry) therapy. HCP should tell pt to report which of the following adverse effects of the drug? SATA Cough Jaundice Paresthesias Tinnitus Fever
Cough Jaundice Paresthesias Tinnitus Fever
HCP should question use of cyclophosphamide for pt w/ which of the following? Charcot-Marie-Tooth syndrome Raynaud's syndrome Jaundice Dehydration
Dehydration Cyclophosphamide, a nitrogen mustard, is contraindicated for patients who have a fluid-volume deficit because dehydration increases the risk for renal toxicity.
HCP caring for pt about to start intrathecal cytarabine (DepoCyt) for mengeal leukemia. HCP should explain that pt should also get which of the following drugs to reduce risk of neurotox? Diphenhydramine Leucovorin Dexamethasone Folic acid
Dexamethasone With the intrathecal form of cytarabine, the patient should also receive dexamethasone, a glucocorticoid, to help decrease the inflammation of the arachnoid that the drug can cause. IV dexamethasone reduces the patient's risk for neurotoxicity.
While assessing a pt receiving interferton alfa-2a (Roferon-A) for Kaposi's sarcoma, HCP should check for which of the following possible indications of adverse reaction? Bradycardia Fever Constipation Dilated pupils
Fever Interferon alfa-2a, a biologic-response modifier, can cause a flu-like reaction, manifesting as fever, myalgia, and fatigue. For this effect, the health care professional should give the patient acetaminophen (Tylenol).
HCP caring for pt about to begin cisplatin for testicular ca. HCP should tell pt to report which of the following adverse effects? SATA Flank pain Sore throat Conjunctivitis Tinnitus Paresthesias
Flank pain Sore throat Tinnitus Paresthesias
When caring for a pt on flutamide for prostate ca, HCP should monitor pt for which of the following adverse effects of the drug? Tachycardia Gynecomastia Constipation Dehydration
Gynecomastia Flutamide, an androgen receptor blocker, treats early and metastatic prostate cancer. It can cause gynecomastia, or growth of breast tissue, decreased libido, and impotence.
HCP assessing pt following trastuzumab (Herception) for metastatic BC. Which of following indicates adverse reaction? SATA Hypotension Dysrhythmias Fever Wheezing Ascites
Hypotension Dysrhythmias Fever Wheezing
HCP caring for pt about to start topotecan (Hycamtin) for resistance SCLC. HCP should caution about taking which OTC with it? Folic acid St Johns worst Aluminum hydroxide Ibuprofen
Ibu NSAIDs, anticoagulants, and antiplatelet drugs increase the patient's risk for bleeding while receiving topotecan, a topoisomerase inhibitor. The health care professional should advise the patient against taking aspirin, ibuprofen (Advil), and other NSAIDs during the therapy.
When talking to pt about to begin vincristine for lymphoma, HCP should include which of the following instructions? Take w/ 8 oz water Report tinnitus/vertigo Allow 4 hrs before taking antacid Increase fiber intake
Increase fiber intake Vincristine, a vinca alkaloid, can cause severe constipation and upper colon fecal impaction. The health care professional should monitor the patient's bowel function and palpate the abdomen for distention. The patient should increase fluid and fiber intake, and take stool softeners.
Unless there are any specific contraindications, which of the following immunizations should adults receive once each year? Tetanus Varicella Hepatitis B Influenza
Influenza All adults should receive the seasonal influenza immunization once per year. All children 6 months older and older adults should also receive this immunization once per year.
HCP about to admin enfuvirtide (Fuzeon). HCP should perform which of the following actions? SATA Inject the solution at room temperature. Expect a cloudy solution. Administer the drug subcutaneously. Roll the vial gently to reconstitute the solution. Discard unused portion.
Inject the solution at room temperature. Administer the drug subcutaneously. Roll the vial gently to reconstitute the solution.
HCP should question use of maraviroc (Selzentry) for pt w/ which of the following? Diabetes mellitus Pancreatitis Meningeal infection Non-chemokine receptor 5 (CCR5)-tropic HIV-1
Non-chemokine receptor 5 (CCR5)-tropic HIV-1 Maraviroc, a CCR5 antagonist, acts by binding to CCR5 and preventing HIV-1 from entering the cell. It is only effective for patients who have CCR5-tropic HIV-1. It is contraindicated for those who do not have CCR5-tropic HIV-1.
HCP caring for pt about to begin marcaptopurine (Purinethol) for leukemia. Which of the following instructions should HCP include when talking w/ pt about the drug? SATA Perform hand hygiene frequently. Use contraception if pregnancy is a risk. Perform oral hygiene frequently. Avoid activities that require mental alertness. Avoid activities that can cause injury.
Perform hand hygiene frequently. Use contraception if pregnancy is a risk. Perform oral hygiene frequently. Avoid activities that can cause injury.
HCP caring for pt about to begin delavirdine (Rescriptor) for HIV1. HCP should tell pt to report which of the following adverse reactions? Rash Insomnia Alopecia Rhinitis
Rash Delavirdine, a non-nucleoside reverse transcriptase inhibitor, can cause a rash. The health care professional should tell the patient to report a rash, which can occur 1 to 3 weeks after therapy, because it can develop into Stevens-Johnson syndrome, a potentially life-threatening complication.
HCP should understand that raltegravir (Isentress) treats pt who have which of the following? Thyroid cancer Resistant HIV disease Kaposi's sarcoma Hairy cell leukemia
Resistant HIV Raltegravir, an integrase inhibitor, along with other antiretroviral drugs, treats HIV disease that is resistant to other drugs. Health care professionals should always give the drug along with other antiretroviral drugs.
Talking w/ pt about to start methotrexate (Trexall) for non Hodgkin lymphoma, HCP should include which of the following instructions? Urinate every 4 hr. Take echinacea supplements. Use a soft-bristled toothbrush. Take aspirin to reduce muscle pain.
Soft toothbrush Methotrexate, a folic acid antagonist, can cause severe bone marrow suppression with decreased thrombocyte counts and also oral and GI ulceration. Patients should use a soft-bristled toothbrush to prevent gum bleeding and mouth trauma.
When considering drug therapy options for a pt w/ metastatic BC + for HER2, HCP should choose which of the following drugs? Imatinib (Gleevec) Flutamide Trastuzumab (Herceptin) Leuprolide (Lupron)
Trastuzumab (Herceptin) Trastuzumab, a monoclonal antibody and a pregnancy risk category D drug, treats metastatic breast cancer with tumors that over express. This type accounts for up to 30% of metastatic breast tumors.
When caring for pt on vincristine for lung ca, HCP should monitor for which of the following findings that indicates an adverse effect? Weak hand grasps Constricted pupils Crackles Bradycardia
Weak hand grasps Vincristine, a vinca alkaloid, can cause peripheral neuropathy. The health care professional should monitor deep-tendon reflexes and the strength and movement of the hands and feet. The health care professional should tell the patient to report paresthesias or reduced sensation in the hands or feet.
HCP caring for pt about to begin imatinib (Gleevec) for CML. Which of the following instructions should the HCP include when talking to pt about taking the drug? SATA Weigh yourself daily. Increase calcium intake. Perform hand hygiene frequently. Clean fruits and vegetables thoroughly. Avoid herbal supplements.
Weigh yourself daily. Perform hand hygiene frequently. Clean fruits and vegetables thoroughly. Avoid herbal supplements.
HCP should question use of anastrozole (Arimidex) for pt who is allergic to salicylates. hearing impaired. immunocompromised. premenopausal.
premenopausal Anastrozole, an aromatase inhibitor, treats early or advanced estrogen receptor-positive breast cancer in postmenopausal women. It is contraindicated for women who are premenopausal as well as for women who are postmenopausal but are taking estrogen. Anastrozole stops tumor growth by inhibiting estrogen synthesis.
HCP caring for pt about to start ritonavir (Norvir) and zidovudine (Retrovir) therapy to treat HIV-1. HCP should explain that the pt will receive ritonavir along with at least one reverse transcriptase inhibitor to increase platelet production. prevent an infusion reaction. protect healthy cells from the toxic effects of ritonavir. prevent drug resistance.
prevent drug resistance. Give zidovudine, a nucleoside reverse transcriptase inhibitor, along with ritonavir, a protease inhibitor, to reduce the risk for drug resistance and to increase drug effectiveness. Monotherapy with zidovudine quickly results in drug resistance, as is also the case with monotherapy with ritonavir.
