Unit 1: Chapter 2

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Guide for the Care and Use of Laboratory Animals

Primary source of the standards and guidelines for laboratory animal care and use in the United States.

The chapter lists some of the requirements in the animal welfare act and the animal welfare regulations if covered species are used. List 5 of these requirements.

1. register with the USDA 2. Maintain individual animal records (including source and use) 3. Provide adequate housing/environment controls for each species 4. Meet/exceed sanitation standards for cages and facility 5. Provide relief of animal pain and distress

Institutional Animal Care and Use Committee

An institutional body that oversees and evaluates an animal care and use program

Quality Assurance Unit

An institutional unit that ensures compliance with the GLP

List 3 components of an animal care and use program for which the Guide describes standards.

Personal qualifications and training, occupational health and safety, veterinary care, animal environment (include housing), animal procedures and transportation, surgical and post surgical care, alleviation of pain and distress, euthanasia, physical plant design and construction

The appropriate use of analgesics in post surgical animals would apply to which of the 3 Rs principles?

Refinement

Good Laboratory Practices

Regulations developed by the FDA and the EPA to validate and document the processes of safety testing.

According to the Animal Welfare Act, list three types of members who must sit on the institutional animal care and use committee

The Chair A veterinarian A non affiliated member

Animal and Plant Health Inspection Service

The body that administers and enforces the Animal Welfare Regulations

Some institutions may have to comply with the PHS policy but not with the animal welfare are and regulations and visa versa. Other institutions must comply with both List two factors that help determine which regulations are relevant to a particular research study

The species of animals used and the funding of sources.

Standard operating procedure

Written instructions approved by management and used to perform a routine activity.

Beyond food, water, shelter, and healthcare requirements, the AWA and AWRs require that dogs have the opportunity for (blank) and NHP have (blank) enrichment

exercise and psychological

Using 100 mice in a research study instead of 150 would be an example of which of the 3 rs

reduction

Office of laboratory animal welfare

the body that administers and enforces the PHS policy.

List two common alternatives to using animals for research studies

Cell cultures and mathematical models

List 3 differences between the PHS Policy and the Animal Welfare Act

PHS policy covers all vertebrates used in Research -AWA does not cover birds, rats, and mice bred for research PHS policy has some administration differences in its IACUAC requirements. PHS requires an occupational Health and Safety Program. PHS Policy requires all federal grant recipients to comply with the US Gov. regulations.

PHS Policy

(Public Health Service) Federal mandate that covers all vertebrates used or intended for use in research, research training, experimentation, biological testing, or for related purposes.

Animal use protocol

A document written by the Principal Investigator and approved by the IACUC, that describes and justifies the use of animals for a project.

Association for the Assessment and Accreditation of Laboratory Animal Care International

A nonprofit organization that accredits a laboratory animal research programs

According to the Guide and PHS policy, what document must institutions comply with when animals are euthanized?

AVMA Guidelines for the Euthanasia of Animals

Which of the following animals used in laboratory animal research would be covered by the Animal Welfare Act?

Guinea Pigs, rabbits, hamsters, ferrets, wild mice, horses, gerbils, goats, sheep


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